Effects of antifungal stewardship using therapeutic drug monitoring in voriconazole therapy on the prevention and control of hepatotoxicity and visual symptoms: A multicentre study conducted in Japan

Summary Background Hepatotoxicity and visual symptoms are common adverse effects (AEs) of voriconazole therapy. Objective To retrospectively evaluate the effects of treatment modification based on therapeutic drug monitoring on AEs in patients undergoing voriconazole therapy. Methods The target vori...

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Veröffentlicht in:	Mycoses 2020-08, Vol.63 (8), p.779-786
Hauptverfasser:	Hamada, Yukihiro, Ueda, Takashi, Miyazaki, Yoshitsugu, Nakajima, Kazuhiko, Fukunaga, Keiko, Miyazaki, Taiga, Nakada‐Motokawa, Nana, Nagao, Miki, Kawamura, Hideki, Shigemi, Akari, Ebihara, Fumiya, Kimura, Toshimi, Ikegame, Kazuhiro, Uchino, Motoi, Ikeuchi, Hiroki, Takesue, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antifungal Agents - administration & dosage Antifungal Agents - adverse effects Antifungal Agents - therapeutic use antifungal stewardship Antimicrobial Stewardship Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Drug dosages Drug Monitoring Drug-Related Side Effects and Adverse Reactions - diagnosis Drug-Related Side Effects and Adverse Reactions - pathology Drug-Related Side Effects and Adverse Reactions - prevention & control Female Hepatotoxicity Humans Male Middle Aged Mycoses - drug therapy Original Retrospective Studies therapeutic drug monitoring visual symptoms Voriconazole Voriconazole - administration & dosage Voriconazole - adverse effects Voriconazole - therapeutic use
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