Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population
Background & Aims Recently, the variant rs72613567:TA in the 17‐beta‐hydroxysteroid dehydrogenase 13 (HSD17B13) has been associated with reduced levels of ALT and AST and a reduced risk of alcohol‐related liver disease (ALD) in the European population. Therefore, the aim of this study was to inv...
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| Veröffentlicht in: | Liver international 2020-09, Vol.40 (9), p.2194-2202 |
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| creator | Chen, Haizhen Zhang, Yanfang Guo, Tongsheng Yang, Funing Mao, Yuanli Li, Liubing Liu, Chenxi Gao, Haidi Jin, Yuting Che, Yuanyuan Li, Yongzhe Huang, Jing |
| description | Background & Aims
Recently, the variant rs72613567:TA in the 17‐beta‐hydroxysteroid dehydrogenase 13 (HSD17B13) has been associated with reduced levels of ALT and AST and a reduced risk of alcohol‐related liver disease (ALD) in the European population. Therefore, the aim of this study was to investigate the association between the polymorphisms of HSD17B13 and ALD, liver serum markers and patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) p.I148M in the Chinese Han population.
Methods
A case‐control study was performed from five centres and included 769 ALD patients and 767 healthy controls. Two SNPs (rs72613567 and rs6834314) in HSD17B13 were genotyped using the Sequenom MassArray system and allele association analysis was performed using PLINK 1.90 software.
Results
HSD17B13 rs72613567:TA allele was associated with a reduced risk of ALD by 19% (95% confidence interval [CI]: 0.05‐0.31, P = .01), uniformly, the G allele in the rs6834314 reduced the risk of ALD by 19% (95% CI: 0.05‐0.31, P = 8.28 × 10−3). And the genotypes of two SNPs were associated with reducing the risk of ALD in three genetic model analysis. In addition, we found that TA allele was associated with lower levels of serum ALT, AST and GGT (P = .005, .007 and .02, respectively), higher level of serum ALB (P = .02), but not associated with ALP. In this cohort, the interaction between HSD17B13 rs72613567 and the steatogenic allele PNPLA3 rs738409 was not validated.
Conclusion
The present study revealed that HSD17B13 rs72613567 was significantly associated with a reduced risk of ALD in Chinese Han population. |
| doi_str_mv | 10.1111/liv.14616 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7496237</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2457970892</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4436-ec911dc0f94623bdaa40bb7608b138a3e8118832dd779a43dfba5155bb0580ca3</originalsourceid><addsrcrecordid>eNp1kU9vFCEYh4nR2Lp68AsYEi_2sC0vzAzMxUS32m2yiQf_XAnDvNOlsrCFmTW9-RH8jH4S0a0bNZELEJ48_OBHyFNgp1DGmXe7U6gaaO6RY6ikmgsu4P5hzcUReZTzNWPQtjU8JEdCQA2NEMckXWDA0Vm6M8mZMNKUJW9A1I2kcaDL9-cgX4OgVwWjCfvJYqbG27iO_vvXbwm9GbGnJQEm2ruMJhfO5c_UBbpYu4BlvzSBbuN2KqyL4TF5MBif8cndPCMf3775sFjOV-8uLhevVnNbVaKZo20BesuGtmq46HpjKtZ1smGqA6GMQAWglOB9L2VrKtEPnamhrruO1YpZI2bk5d67nboN9hbDmIzX2-Q2Jt3qaJz--yS4tb6KOy2rttwoi-DFnSDFmwnzqDcuW_TeBIxT1ryqZSuZanlBn_-DXscphfK8QgkuFecl64yc7CmbYs4Jh0MYYPpnk7r8o_7VZGGf_Zn-QP6urgBne-CL83j7f5NeXX7aK38ALd6oAQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2432782288</pqid></control><display><type>article</type><title>Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chen, Haizhen ; Zhang, Yanfang ; Guo, Tongsheng ; Yang, Funing ; Mao, Yuanli ; Li, Liubing ; Liu, Chenxi ; Gao, Haidi ; Jin, Yuting ; Che, Yuanyuan ; Li, Yongzhe ; Huang, Jing</creator><creatorcontrib>Chen, Haizhen ; Zhang, Yanfang ; Guo, Tongsheng ; Yang, Funing ; Mao, Yuanli ; Li, Liubing ; Liu, Chenxi ; Gao, Haidi ; Jin, Yuting ; Che, Yuanyuan ; Li, Yongzhe ; Huang, Jing</creatorcontrib><description>Background & Aims
Recently, the variant rs72613567:TA in the 17‐beta‐hydroxysteroid dehydrogenase 13 (HSD17B13) has been associated with reduced levels of ALT and AST and a reduced risk of alcohol‐related liver disease (ALD) in the European population. Therefore, the aim of this study was to investigate the association between the polymorphisms of HSD17B13 and ALD, liver serum markers and patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) p.I148M in the Chinese Han population.
Methods
A case‐control study was performed from five centres and included 769 ALD patients and 767 healthy controls. Two SNPs (rs72613567 and rs6834314) in HSD17B13 were genotyped using the Sequenom MassArray system and allele association analysis was performed using PLINK 1.90 software.
Results
HSD17B13 rs72613567:TA allele was associated with a reduced risk of ALD by 19% (95% confidence interval [CI]: 0.05‐0.31, P = .01), uniformly, the G allele in the rs6834314 reduced the risk of ALD by 19% (95% CI: 0.05‐0.31, P = 8.28 × 10−3). And the genotypes of two SNPs were associated with reducing the risk of ALD in three genetic model analysis. In addition, we found that TA allele was associated with lower levels of serum ALT, AST and GGT (P = .005, .007 and .02, respectively), higher level of serum ALB (P = .02), but not associated with ALP. In this cohort, the interaction between HSD17B13 rs72613567 and the steatogenic allele PNPLA3 rs738409 was not validated.
Conclusion
The present study revealed that HSD17B13 rs72613567 was significantly associated with a reduced risk of ALD in Chinese Han population.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.14616</identifier><identifier>PMID: 33151633</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>alcohol‐related liver disease ; Alleles ; Association analysis ; Case-Control Studies ; China ; Confidence intervals ; Control methods ; Genetic analysis ; Genetic diversity ; Genetic Predisposition to Disease ; Genetic variance ; Genetics and Rare Liver Diseases ; Genotypes ; Health risks ; HSD17B13 ; Humans ; Hydroxysteroids ; Liver ; Liver Diseases ; Original ; Phospholipase ; Polymorphism, Single Nucleotide ; Population ; Risk management ; Single-nucleotide polymorphism</subject><ispartof>Liver international, 2020-09, Vol.40 (9), p.2194-2202</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd</rights><rights>2020 The Authors. Liver International published by John Wiley & Sons Ltd.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-ec911dc0f94623bdaa40bb7608b138a3e8118832dd779a43dfba5155bb0580ca3</citedby><cites>FETCH-LOGICAL-c4436-ec911dc0f94623bdaa40bb7608b138a3e8118832dd779a43dfba5155bb0580ca3</cites><orcidid>0000-0002-8267-0985 ; 0000-0001-9663-9607 ; 0000-0002-8150-7123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.14616$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.14616$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33151633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Haizhen</creatorcontrib><creatorcontrib>Zhang, Yanfang</creatorcontrib><creatorcontrib>Guo, Tongsheng</creatorcontrib><creatorcontrib>Yang, Funing</creatorcontrib><creatorcontrib>Mao, Yuanli</creatorcontrib><creatorcontrib>Li, Liubing</creatorcontrib><creatorcontrib>Liu, Chenxi</creatorcontrib><creatorcontrib>Gao, Haidi</creatorcontrib><creatorcontrib>Jin, Yuting</creatorcontrib><creatorcontrib>Che, Yuanyuan</creatorcontrib><creatorcontrib>Li, Yongzhe</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><title>Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background & Aims
Recently, the variant rs72613567:TA in the 17‐beta‐hydroxysteroid dehydrogenase 13 (HSD17B13) has been associated with reduced levels of ALT and AST and a reduced risk of alcohol‐related liver disease (ALD) in the European population. Therefore, the aim of this study was to investigate the association between the polymorphisms of HSD17B13 and ALD, liver serum markers and patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) p.I148M in the Chinese Han population.
Methods
A case‐control study was performed from five centres and included 769 ALD patients and 767 healthy controls. Two SNPs (rs72613567 and rs6834314) in HSD17B13 were genotyped using the Sequenom MassArray system and allele association analysis was performed using PLINK 1.90 software.
Results
HSD17B13 rs72613567:TA allele was associated with a reduced risk of ALD by 19% (95% confidence interval [CI]: 0.05‐0.31, P = .01), uniformly, the G allele in the rs6834314 reduced the risk of ALD by 19% (95% CI: 0.05‐0.31, P = 8.28 × 10−3). And the genotypes of two SNPs were associated with reducing the risk of ALD in three genetic model analysis. In addition, we found that TA allele was associated with lower levels of serum ALT, AST and GGT (P = .005, .007 and .02, respectively), higher level of serum ALB (P = .02), but not associated with ALP. In this cohort, the interaction between HSD17B13 rs72613567 and the steatogenic allele PNPLA3 rs738409 was not validated.
Conclusion
The present study revealed that HSD17B13 rs72613567 was significantly associated with a reduced risk of ALD in Chinese Han population.</description><subject>alcohol‐related liver disease</subject><subject>Alleles</subject><subject>Association analysis</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Confidence intervals</subject><subject>Control methods</subject><subject>Genetic analysis</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic variance</subject><subject>Genetics and Rare Liver Diseases</subject><subject>Genotypes</subject><subject>Health risks</subject><subject>HSD17B13</subject><subject>Humans</subject><subject>Hydroxysteroids</subject><subject>Liver</subject><subject>Liver Diseases</subject><subject>Original</subject><subject>Phospholipase</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Risk management</subject><subject>Single-nucleotide polymorphism</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU9vFCEYh4nR2Lp68AsYEi_2sC0vzAzMxUS32m2yiQf_XAnDvNOlsrCFmTW9-RH8jH4S0a0bNZELEJ48_OBHyFNgp1DGmXe7U6gaaO6RY6ikmgsu4P5hzcUReZTzNWPQtjU8JEdCQA2NEMckXWDA0Vm6M8mZMNKUJW9A1I2kcaDL9-cgX4OgVwWjCfvJYqbG27iO_vvXbwm9GbGnJQEm2ruMJhfO5c_UBbpYu4BlvzSBbuN2KqyL4TF5MBif8cndPCMf3775sFjOV-8uLhevVnNbVaKZo20BesuGtmq46HpjKtZ1smGqA6GMQAWglOB9L2VrKtEPnamhrruO1YpZI2bk5d67nboN9hbDmIzX2-Q2Jt3qaJz--yS4tb6KOy2rttwoi-DFnSDFmwnzqDcuW_TeBIxT1ryqZSuZanlBn_-DXscphfK8QgkuFecl64yc7CmbYs4Jh0MYYPpnk7r8o_7VZGGf_Zn-QP6urgBne-CL83j7f5NeXX7aK38ALd6oAQ</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Chen, Haizhen</creator><creator>Zhang, Yanfang</creator><creator>Guo, Tongsheng</creator><creator>Yang, Funing</creator><creator>Mao, Yuanli</creator><creator>Li, Liubing</creator><creator>Liu, Chenxi</creator><creator>Gao, Haidi</creator><creator>Jin, Yuting</creator><creator>Che, Yuanyuan</creator><creator>Li, Yongzhe</creator><creator>Huang, Jing</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8267-0985</orcidid><orcidid>https://orcid.org/0000-0001-9663-9607</orcidid><orcidid>https://orcid.org/0000-0002-8150-7123</orcidid></search><sort><creationdate>202009</creationdate><title>Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population</title><author>Chen, Haizhen ; Zhang, Yanfang ; Guo, Tongsheng ; Yang, Funing ; Mao, Yuanli ; Li, Liubing ; Liu, Chenxi ; Gao, Haidi ; Jin, Yuting ; Che, Yuanyuan ; Li, Yongzhe ; Huang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-ec911dc0f94623bdaa40bb7608b138a3e8118832dd779a43dfba5155bb0580ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>alcohol‐related liver disease</topic><topic>Alleles</topic><topic>Association analysis</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Confidence intervals</topic><topic>Control methods</topic><topic>Genetic analysis</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic variance</topic><topic>Genetics and Rare Liver Diseases</topic><topic>Genotypes</topic><topic>Health risks</topic><topic>HSD17B13</topic><topic>Humans</topic><topic>Hydroxysteroids</topic><topic>Liver</topic><topic>Liver Diseases</topic><topic>Original</topic><topic>Phospholipase</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Risk management</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Haizhen</creatorcontrib><creatorcontrib>Zhang, Yanfang</creatorcontrib><creatorcontrib>Guo, Tongsheng</creatorcontrib><creatorcontrib>Yang, Funing</creatorcontrib><creatorcontrib>Mao, Yuanli</creatorcontrib><creatorcontrib>Li, Liubing</creatorcontrib><creatorcontrib>Liu, Chenxi</creatorcontrib><creatorcontrib>Gao, Haidi</creatorcontrib><creatorcontrib>Jin, Yuting</creatorcontrib><creatorcontrib>Che, Yuanyuan</creatorcontrib><creatorcontrib>Li, Yongzhe</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Haizhen</au><au>Zhang, Yanfang</au><au>Guo, Tongsheng</au><au>Yang, Funing</au><au>Mao, Yuanli</au><au>Li, Liubing</au><au>Liu, Chenxi</au><au>Gao, Haidi</au><au>Jin, Yuting</au><au>Che, Yuanyuan</au><au>Li, Yongzhe</au><au>Huang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2020-09</date><risdate>2020</risdate><volume>40</volume><issue>9</issue><spage>2194</spage><epage>2202</epage><pages>2194-2202</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background & Aims
Recently, the variant rs72613567:TA in the 17‐beta‐hydroxysteroid dehydrogenase 13 (HSD17B13) has been associated with reduced levels of ALT and AST and a reduced risk of alcohol‐related liver disease (ALD) in the European population. Therefore, the aim of this study was to investigate the association between the polymorphisms of HSD17B13 and ALD, liver serum markers and patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) p.I148M in the Chinese Han population.
Methods
A case‐control study was performed from five centres and included 769 ALD patients and 767 healthy controls. Two SNPs (rs72613567 and rs6834314) in HSD17B13 were genotyped using the Sequenom MassArray system and allele association analysis was performed using PLINK 1.90 software.
Results
HSD17B13 rs72613567:TA allele was associated with a reduced risk of ALD by 19% (95% confidence interval [CI]: 0.05‐0.31, P = .01), uniformly, the G allele in the rs6834314 reduced the risk of ALD by 19% (95% CI: 0.05‐0.31, P = 8.28 × 10−3). And the genotypes of two SNPs were associated with reducing the risk of ALD in three genetic model analysis. In addition, we found that TA allele was associated with lower levels of serum ALT, AST and GGT (P = .005, .007 and .02, respectively), higher level of serum ALB (P = .02), but not associated with ALP. In this cohort, the interaction between HSD17B13 rs72613567 and the steatogenic allele PNPLA3 rs738409 was not validated.
Conclusion
The present study revealed that HSD17B13 rs72613567 was significantly associated with a reduced risk of ALD in Chinese Han population.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33151633</pmid><doi>10.1111/liv.14616</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8267-0985</orcidid><orcidid>https://orcid.org/0000-0001-9663-9607</orcidid><orcidid>https://orcid.org/0000-0002-8150-7123</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | alcohol‐related liver disease Alleles Association analysis Case-Control Studies China Confidence intervals Control methods Genetic analysis Genetic diversity Genetic Predisposition to Disease Genetic variance Genetics and Rare Liver Diseases Genotypes Health risks HSD17B13 Humans Hydroxysteroids Liver Liver Diseases Original Phospholipase Polymorphism, Single Nucleotide Population Risk management Single-nucleotide polymorphism |
| title | Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population |
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