Synthesis of Tetramic Acid Fragments Derived from Vancoresmycin Showing Inhibitory Effects towards S. aureus

An efficient route to various vancoresmycin‐type tetramic acids has been developed. The modular route is based on an effective Fries‐type rearrangement to introduce various appending acetyl residues. The minimum inhibitory concentration (MIC) values of the new tetramic acids against Staphylococcus a...

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Veröffentlicht in:	ChemMedChem 2020-08, Vol.15 (15), p.1390-1393
Hauptverfasser:	Wingen, Lukas Martin, Rausch, Marvin, Schneider, Tanja, Menche, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibiotics Antimicrobial activity Bioactive compounds Biosynthesis Cell walls Communication Communications E coli Lipids Minimum inhibitory concentration tautomerism tetramic acids vancoresmycin
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