Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A

Replication of the genotype 2 hepatitis C virus (HCV) requires hyperphosphorylation of the nonstructural protein NS5A. It has been known that NS5A hyperphosphorylation results from the phosphorylation of a cluster of highly conserved serine residues (S2201, S2208, S2211, and S2214) in a sequential m...

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Veröffentlicht in:	Journal of virology 2020-09, Vol.94 (19)
Hauptverfasser:	Chiang, Cho-Han, Lai, Yen-Ling, Huang, Yu-Ning, Yu, Chun-Chiao, Lu, Christine C, Yu, Guann-Yi, Yu, Ming-Jiun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Genome and Regulation of Viral Gene Expression HEK293 Cells Hepacivirus - metabolism Humans Mutation Phosphorylation Polyproteins - metabolism RNA Helicases Viral Nonstructural Proteins - metabolism
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