Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice

BACKGROUND:Experimental evidence shows postnatal exposure to anesthesia negatively affects brain development. The PDZ2 domain, mediating protein–protein interactions of the postsynaptic density-95 protein, serves as a molecular target for several inhaled anesthetics. The authors hypothesized that ea...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2020-10, Vol.133 (4), p.812-823
Hauptverfasser:	Schaefer, Michele L., Perez, Patric J., Wang, Meina, Gray, Christy, Krall, Caroline, Sun, Xiaoning, Hunter, Elizabeth, Skinner, John, Johns, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - toxicity Animals Animals, Newborn Cognition - drug effects Cognition - physiology Dendritic Spines - drug effects Dendritic Spines - pathology Dendritic Spines - physiology Disks Large Homolog 4 Protein - antagonists & inhibitors Disks Large Homolog 4 Protein - physiology Female Isoflurane - toxicity Male Mice Mice, Inbred C57BL Organ Culture Techniques Peptides - pharmacology Post-Synaptic Density - drug effects Post-Synaptic Density - pathology Post-Synaptic Density - physiology
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