Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults
Abstract Background Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep–fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-09, Vol.75 (9), p.e95-e102 |
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| creator | Alfini, Alfonso J Schrack, Jennifer A Urbanek, Jacek K Wanigatunga, Amal A Wanigatunga, Sarah K Zipunnikov, Vadim Ferrucci, Luigi Simonsick, Eleanor M Spira, Adam P |
| description | Abstract
Background
Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep–fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability—fatigue in response to a standardized task—and with conventional fatigue symptoms of low energy or tiredness.
Methods
We studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue.
Results
After adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; |
| doi_str_mv | 10.1093/gerona/glaa137 |
| format | Article |
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Background
Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep–fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability—fatigue in response to a standardized task—and with conventional fatigue symptoms of low energy or tiredness.
Methods
We studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue.
Results
After adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; <6.3 hours vs intermediate TST ≥6.3 to 7.2 hours) was associated with high RPE fatigability (odds ratio [OR] = 2.56, 95% confidence interval [CI] = 1.29, 5.06, p = .007), high PFS physical (OR = 1.88, 95% CI = 1.04, 3.38, p = .035), and high mental fatigability (OR = 2.15, 95% CI = 1.02, 4.50, p = .044), whereas longer TST was also associated with high mental fatigability (OR = 2.19, 95% CI = 1.02, 4.71, p = .043). Additionally, longer wake bout length was associated with high RPE fatigability (OR = 1.53, 95% CI = 1.14, 2.07, p = .005), and greater wake after sleep onset was associated with high mental fatigability (OR = 1.14, 95% CI = 1.01, 1.28, p = .036).
Conclusion
Among well-functioning older adults, abnormal sleep duration and sleep fragmentation are associated with greater perceived fatigability.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glaa137</identifier><identifier>PMID: 32502253</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Actigraphy ; Aged ; Aging ; Cognitive ability ; Cross-Sectional Studies ; Exercise Test ; Fatigue ; Fatigue - etiology ; Fatigue - physiopathology ; Female ; Humans ; Male ; Older people ; Physical Exertion ; Sleep ; Sleep - physiology ; Sleep and wakefulness ; Sleep Wake Disorders - complications ; Sleep Wake Disorders - diagnosis ; Sleep Wake Disorders - physiopathology ; Surveys and Questionnaires ; THE JOURNAL OF GERONTOLOGY: Medical Sciences ; Wrist</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2020-09, Vol.75 (9), p.e95-e102</ispartof><rights>Published by Oxford University Press on behalf of The Gerontological Society of America 2020. 2020</rights><rights>Published by Oxford University Press on behalf of The Gerontological Society of America 2020.</rights><rights>Copyright Oxford University Press Sep 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-4d38727728fd67b987cc1829704821b47855983c3f8671228f0dc429ef129eb93</citedby><cites>FETCH-LOGICAL-c452t-4d38727728fd67b987cc1829704821b47855983c3f8671228f0dc429ef129eb93</cites><orcidid>0000-0002-6273-1613 ; 0000-0001-9244-9267 ; 0000-0002-8743-8923 ; 0000-0002-5763-5184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32502253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Newman, Anne</contributor><creatorcontrib>Alfini, Alfonso J</creatorcontrib><creatorcontrib>Schrack, Jennifer A</creatorcontrib><creatorcontrib>Urbanek, Jacek K</creatorcontrib><creatorcontrib>Wanigatunga, Amal A</creatorcontrib><creatorcontrib>Wanigatunga, Sarah K</creatorcontrib><creatorcontrib>Zipunnikov, Vadim</creatorcontrib><creatorcontrib>Ferrucci, Luigi</creatorcontrib><creatorcontrib>Simonsick, Eleanor M</creatorcontrib><creatorcontrib>Spira, Adam P</creatorcontrib><title>Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
Background
Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep–fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability—fatigue in response to a standardized task—and with conventional fatigue symptoms of low energy or tiredness.
Methods
We studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue.
Results
After adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; <6.3 hours vs intermediate TST ≥6.3 to 7.2 hours) was associated with high RPE fatigability (odds ratio [OR] = 2.56, 95% confidence interval [CI] = 1.29, 5.06, p = .007), high PFS physical (OR = 1.88, 95% CI = 1.04, 3.38, p = .035), and high mental fatigability (OR = 2.15, 95% CI = 1.02, 4.50, p = .044), whereas longer TST was also associated with high mental fatigability (OR = 2.19, 95% CI = 1.02, 4.71, p = .043). Additionally, longer wake bout length was associated with high RPE fatigability (OR = 1.53, 95% CI = 1.14, 2.07, p = .005), and greater wake after sleep onset was associated with high mental fatigability (OR = 1.14, 95% CI = 1.01, 1.28, p = .036).
Conclusion
Among well-functioning older adults, abnormal sleep duration and sleep fragmentation are associated with greater perceived fatigability.</description><subject>Actigraphy</subject><subject>Aged</subject><subject>Aging</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Exercise Test</subject><subject>Fatigue</subject><subject>Fatigue - etiology</subject><subject>Fatigue - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Older people</subject><subject>Physical Exertion</subject><subject>Sleep</subject><subject>Sleep - physiology</subject><subject>Sleep and wakefulness</subject><subject>Sleep Wake Disorders - complications</subject><subject>Sleep Wake Disorders - diagnosis</subject><subject>Sleep Wake Disorders - physiopathology</subject><subject>Surveys and Questionnaires</subject><subject>THE JOURNAL OF GERONTOLOGY: Medical Sciences</subject><subject>Wrist</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LHDEABuBQWqrVXnssgV70MJrPSeYiLKJVEBVssbeQyWRmI9nJmGQE_71ZdpXWS3NIAnnykvAC8A2jI4waejzYGEZ9PHitMRUfwC4WXFac8j8fyx6JpuII1TvgS0oPaD04-Qx2KOGIEE53wfUipWCczi6MCYYeLkx2Q9TT0hl4562d4K2OemWzjQneu7yE5wUPunXe5WfoRnjjOxvhopt9TvvgU699sl-36x74fX726_Siurr5eXm6uKoM4yRXrKNSECGI7LtatI0UxmBJGoGYJLhlQnLeSGpoL2uBSWGoM4w0tsdlahu6B042udPcrmxn7Jij9mqKbqXjswraqX9PRrdUQ3hSgjUMEVQCDrYBMTzONmW1cslY7_Vow5wUYRjRWnC2pj_e0Ycwx7F8ryjGucQ1r4s62igTQ0rR9m-PwUitq1KbqtS2qnLh-99feOOv3RRwuAFhnv4X9gL24Z8V</recordid><startdate>20200916</startdate><enddate>20200916</enddate><creator>Alfini, Alfonso J</creator><creator>Schrack, Jennifer A</creator><creator>Urbanek, Jacek K</creator><creator>Wanigatunga, Amal A</creator><creator>Wanigatunga, Sarah K</creator><creator>Zipunnikov, Vadim</creator><creator>Ferrucci, Luigi</creator><creator>Simonsick, Eleanor M</creator><creator>Spira, Adam P</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6273-1613</orcidid><orcidid>https://orcid.org/0000-0001-9244-9267</orcidid><orcidid>https://orcid.org/0000-0002-8743-8923</orcidid><orcidid>https://orcid.org/0000-0002-5763-5184</orcidid></search><sort><creationdate>20200916</creationdate><title>Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults</title><author>Alfini, Alfonso J ; Schrack, Jennifer A ; Urbanek, Jacek K ; Wanigatunga, Amal A ; Wanigatunga, Sarah K ; Zipunnikov, Vadim ; Ferrucci, Luigi ; Simonsick, Eleanor M ; Spira, Adam P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-4d38727728fd67b987cc1829704821b47855983c3f8671228f0dc429ef129eb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Actigraphy</topic><topic>Aged</topic><topic>Aging</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Exercise Test</topic><topic>Fatigue</topic><topic>Fatigue - etiology</topic><topic>Fatigue - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Older people</topic><topic>Physical Exertion</topic><topic>Sleep</topic><topic>Sleep - physiology</topic><topic>Sleep and wakefulness</topic><topic>Sleep Wake Disorders - complications</topic><topic>Sleep Wake Disorders - diagnosis</topic><topic>Sleep Wake Disorders - physiopathology</topic><topic>Surveys and Questionnaires</topic><topic>THE JOURNAL OF GERONTOLOGY: Medical Sciences</topic><topic>Wrist</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alfini, Alfonso J</creatorcontrib><creatorcontrib>Schrack, Jennifer A</creatorcontrib><creatorcontrib>Urbanek, Jacek K</creatorcontrib><creatorcontrib>Wanigatunga, Amal A</creatorcontrib><creatorcontrib>Wanigatunga, Sarah K</creatorcontrib><creatorcontrib>Zipunnikov, Vadim</creatorcontrib><creatorcontrib>Ferrucci, Luigi</creatorcontrib><creatorcontrib>Simonsick, Eleanor M</creatorcontrib><creatorcontrib>Spira, Adam P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alfini, Alfonso J</au><au>Schrack, Jennifer A</au><au>Urbanek, Jacek K</au><au>Wanigatunga, Amal A</au><au>Wanigatunga, Sarah K</au><au>Zipunnikov, Vadim</au><au>Ferrucci, Luigi</au><au>Simonsick, Eleanor M</au><au>Spira, Adam P</au><au>Newman, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2020-09-16</date><risdate>2020</risdate><volume>75</volume><issue>9</issue><spage>e95</spage><epage>e102</epage><pages>e95-e102</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Abstract
Background
Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep–fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability—fatigue in response to a standardized task—and with conventional fatigue symptoms of low energy or tiredness.
Methods
We studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue.
Results
After adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; <6.3 hours vs intermediate TST ≥6.3 to 7.2 hours) was associated with high RPE fatigability (odds ratio [OR] = 2.56, 95% confidence interval [CI] = 1.29, 5.06, p = .007), high PFS physical (OR = 1.88, 95% CI = 1.04, 3.38, p = .035), and high mental fatigability (OR = 2.15, 95% CI = 1.02, 4.50, p = .044), whereas longer TST was also associated with high mental fatigability (OR = 2.19, 95% CI = 1.02, 4.71, p = .043). Additionally, longer wake bout length was associated with high RPE fatigability (OR = 1.53, 95% CI = 1.14, 2.07, p = .005), and greater wake after sleep onset was associated with high mental fatigability (OR = 1.14, 95% CI = 1.01, 1.28, p = .036).
Conclusion
Among well-functioning older adults, abnormal sleep duration and sleep fragmentation are associated with greater perceived fatigability.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32502253</pmid><doi>10.1093/gerona/glaa137</doi><orcidid>https://orcid.org/0000-0002-6273-1613</orcidid><orcidid>https://orcid.org/0000-0001-9244-9267</orcidid><orcidid>https://orcid.org/0000-0002-8743-8923</orcidid><orcidid>https://orcid.org/0000-0002-5763-5184</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Actigraphy Aged Aging Cognitive ability Cross-Sectional Studies Exercise Test Fatigue Fatigue - etiology Fatigue - physiopathology Female Humans Male Older people Physical Exertion Sleep Sleep - physiology Sleep and wakefulness Sleep Wake Disorders - complications Sleep Wake Disorders - diagnosis Sleep Wake Disorders - physiopathology Surveys and Questionnaires THE JOURNAL OF GERONTOLOGY: Medical Sciences Wrist |
| title | Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults |
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