Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing

Axonal degeneration is a key and early pathological feature in traumatic and neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal disintegration by acute axonal degeneration (AAD) occurs within several hours. During AAD, the accumulation of autophagic proteins i...

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Veröffentlicht in:	Cell death and differentiation 2020-10, Vol.27 (10), p.2810-2827
Hauptverfasser:	Vahsen, Björn Friedhelm, Ribas, Vinicius Toledo, Sundermeyer, Jonas, Boecker, Alexander, Dambeck, Vivian, Lenz, Christof, Shomroni, Orr, Caldi Gomes, Lucas, Tatenhorst, Lars, Barski, Elisabeth, Roser, Anna-Elisa, Michel, Uwe, Urlaub, Henning, Salinas, Gabriela, Bähr, Mathias, Koch, Jan Christoph, Lingor, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/106 13/51 13/62 14/63 38 38/91 631/378 692/308/1426 692/308/575 692/699/375 82/80 96/44 Apoptosis Autophagy Axotomy Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Life Sciences Neurodegeneration Neurodegenerative diseases Optic nerve Phagocytosis Spinal cord injuries Splicing Stem Cells TOR protein
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