Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling

Bitter taste receptors (T2Rs) are GPCRs involved in detection of bitter compounds by type 2 taste cells of the tongue, but are also expressed in other tissues throughout the body, including the airways, gastrointestinal tract, and brain. These T2Rs can be activated by several bacterial products and...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-01, Vol.78 (1), p.271-286
Hauptverfasser:	Gopallawa, Indiwari, Freund, Jenna R., Lee, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bitter taste Calcium Calcium - metabolism Calcium compounds Calcium oxide Calcium signalling Cell Biology Cell Communication Cell culture Cells, Cultured Cellular manufacture Coculture Techniques Cyclic AMP Cyclic GMP Cyclic GMP - metabolism Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Gastrointestinal system Gastrointestinal tract Humans Imaging techniques Immune response Immune system Innate immunity Inositol 1,4,5-trisphosphate receptors Isoforms Kinases Leukocytes (neutrophilic) Life Sciences Lime Macrophages Macrophages - cytology Macrophages - immunology Macrophages - metabolism Monocytes Monocytes - cytology Monocytes - metabolism Neuroimaging Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Original Article Pertussis Pertussis toxin Pertussis Toxin - pharmacology Phagocytosis Phagocytosis - drug effects Phospholipase Phospholipase C Physostigmine - analogs & derivatives Physostigmine - pharmacology Protein kinase Quinolones - pharmacology Receptors Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Signal transduction Signal Transduction - drug effects Signaling Taste Toxins
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