SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers
Summary Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA sampl...
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| Veröffentlicht in: | Animal genetics 2020-10, Vol.51 (5), p.824-828 |
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| creator | Cook, S. R. Conzemius, M. G. McCue, M. E. Ekenstedt, K. J. |
| description | Summary
Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR‐affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever. |
| doi_str_mv | 10.1111/age.12978 |
| format | Article |
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Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR‐affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever.</description><identifier>ISSN: 0268-9146</identifier><identifier>EISSN: 1365-2052</identifier><identifier>DOI: 10.1111/age.12978</identifier><identifier>PMID: 32696518</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Algorithms ; Animals ; Anterior cruciate ligament ; Anterior Cruciate Ligament Injuries - genetics ; Anterior Cruciate Ligament Injuries - pathology ; Arrays ; Bayesian analysis ; canine ; covariates ; Deoxyribonucleic acid ; DNA ; dog ; Dogs ; Dogs - genetics ; Dogs - injuries ; Female ; Genotyping ; Heredity ; Heritability ; heritability programs ; Ligaments ; Male ; Mathematical models ; Orthopedics ; Rupture ; Single-nucleotide polymorphism ; Skull ; Sterilization</subject><ispartof>Animal genetics, 2020-10, Vol.51 (5), p.824-828</ispartof><rights>2020 Stichting International Foundation for Animal Genetics</rights><rights>2020 Stichting International Foundation for Animal Genetics.</rights><rights>Copyright © 2020 Stichting International Foundation for Animal Genetics</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-3ccc62d93c6e954db4ad16a7a597f56209571ef9c65492c444d4d9fc48a5b3bd3</citedby><cites>FETCH-LOGICAL-c4438-3ccc62d93c6e954db4ad16a7a597f56209571ef9c65492c444d4d9fc48a5b3bd3</cites><orcidid>0000-0002-6807-0318 ; 0000-0002-3213-7883 ; 0000-0001-7967-9607 ; 0000-0001-6513-1413</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fage.12978$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fage.12978$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32696518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cook, S. R.</creatorcontrib><creatorcontrib>Conzemius, M. G.</creatorcontrib><creatorcontrib>McCue, M. E.</creatorcontrib><creatorcontrib>Ekenstedt, K. J.</creatorcontrib><title>SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers</title><title>Animal genetics</title><addtitle>Anim Genet</addtitle><description>Summary
Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR‐affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Anterior cruciate ligament</subject><subject>Anterior Cruciate Ligament Injuries - genetics</subject><subject>Anterior Cruciate Ligament Injuries - pathology</subject><subject>Arrays</subject><subject>Bayesian analysis</subject><subject>canine</subject><subject>covariates</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>dog</subject><subject>Dogs</subject><subject>Dogs - genetics</subject><subject>Dogs - injuries</subject><subject>Female</subject><subject>Genotyping</subject><subject>Heredity</subject><subject>Heritability</subject><subject>heritability programs</subject><subject>Ligaments</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Orthopedics</subject><subject>Rupture</subject><subject>Single-nucleotide polymorphism</subject><subject>Skull</subject><subject>Sterilization</subject><issn>0268-9146</issn><issn>1365-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctuFDEQRS0EIpOEBT-ALLEhi07abj_aG6QoCgFpBCgJa6varp5x1I_B7g6aHZ_AN_IlOJkQARK1qUUdH13rEvKSlccszwms8Jhxo-snZMEqJQteSv6ULEqu6sIwofbIfko3ZVnWTLPnZK_iyijJ6gXprz5-_vn9RwMJPV1jDBM0oQvTlsLg6QoHnIKjEN06TOimOSIdW-oiDAG6vGcXYELahRX0OEw0zpt7KAx0CU0EP0Z6iVMMeIsxHZJnLXQJXzzsA_Ll3fn12fti-eniw9npsnBCVHVROecU96ZyCo0UvhHgmQIN0uhWKl4aqRm2xikpDM9vhBfetE7UIJuq8dUBebvzbuamR-9ysgid3cTQQ9zaEYL9-zKEtV2Nt1ZnX6VlFrx5EMTx64xpsn1IDrsOBhznZLngimldKZ3R1_-gN-Mch_y9TAmmdA55Rx3tKBfHlCK2j2FYae9KtLlEe19iZl_9mf6R_N1aBk52wLfQ4fb_Jnt6cb5T_gJOI6lJ</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Cook, S. R.</creator><creator>Conzemius, M. G.</creator><creator>McCue, M. E.</creator><creator>Ekenstedt, K. J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6807-0318</orcidid><orcidid>https://orcid.org/0000-0002-3213-7883</orcidid><orcidid>https://orcid.org/0000-0001-7967-9607</orcidid><orcidid>https://orcid.org/0000-0001-6513-1413</orcidid></search><sort><creationdate>202010</creationdate><title>SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers</title><author>Cook, S. R. ; Conzemius, M. G. ; McCue, M. E. ; Ekenstedt, K. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-3ccc62d93c6e954db4ad16a7a597f56209571ef9c65492c444d4d9fc48a5b3bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Anterior cruciate ligament</topic><topic>Anterior Cruciate Ligament Injuries - genetics</topic><topic>Anterior Cruciate Ligament Injuries - pathology</topic><topic>Arrays</topic><topic>Bayesian analysis</topic><topic>canine</topic><topic>covariates</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>dog</topic><topic>Dogs</topic><topic>Dogs - genetics</topic><topic>Dogs - injuries</topic><topic>Female</topic><topic>Genotyping</topic><topic>Heredity</topic><topic>Heritability</topic><topic>heritability programs</topic><topic>Ligaments</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Orthopedics</topic><topic>Rupture</topic><topic>Single-nucleotide polymorphism</topic><topic>Skull</topic><topic>Sterilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, S. R.</creatorcontrib><creatorcontrib>Conzemius, M. G.</creatorcontrib><creatorcontrib>McCue, M. E.</creatorcontrib><creatorcontrib>Ekenstedt, K. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Animal genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cook, S. R.</au><au>Conzemius, M. G.</au><au>McCue, M. E.</au><au>Ekenstedt, K. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers</atitle><jtitle>Animal genetics</jtitle><addtitle>Anim Genet</addtitle><date>2020-10</date><risdate>2020</risdate><volume>51</volume><issue>5</issue><spage>824</spage><epage>828</epage><pages>824-828</pages><issn>0268-9146</issn><eissn>1365-2052</eissn><abstract>Summary
Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR‐affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32696518</pmid><doi>10.1111/age.12978</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6807-0318</orcidid><orcidid>https://orcid.org/0000-0002-3213-7883</orcidid><orcidid>https://orcid.org/0000-0001-7967-9607</orcidid><orcidid>https://orcid.org/0000-0001-6513-1413</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Algorithms Animals Anterior cruciate ligament Anterior Cruciate Ligament Injuries - genetics Anterior Cruciate Ligament Injuries - pathology Arrays Bayesian analysis canine covariates Deoxyribonucleic acid DNA dog Dogs Dogs - genetics Dogs - injuries Female Genotyping Heredity Heritability heritability programs Ligaments Male Mathematical models Orthopedics Rupture Single-nucleotide polymorphism Skull Sterilization |
| title | SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers |
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