WD repeat-containing protein 1 maintains β-Catenin activity to promote pancreatic cancer aggressiveness

Background The molecular signature underlying pancreatic ductal adenocarcinoma (PDAC) progression may include key proteins affecting the malignant phenotypes. Here, we aimed to identify the proteins implicated in PDAC with different tumour-node-metastasis (TNM) stages. Methods Eight-plex isobaric ta...

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Veröffentlicht in:	British journal of cancer 2020-09, Vol.123 (6), p.1012-1023
Hauptverfasser:	Li, Hengchao, Liu, Xiaohui, Jiang, Shuheng, Zhou, Xinwen, Yao, Lie, Di, Yang, Jiang, Yongjian, Gu, Jichun, Mao, Yishen, Li, Ji, Jin, Chen, Yang, Pengyuan, Fu, Deliang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2163 692/4028/67/2332 Adenocarcinoma Animals beta Catenin - physiology Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Drug Resistance Ectopic expression Epidemiology Humans Immunoprecipitation Liquid chromatography Male Mass spectroscopy Metastases Metastasis Mice Microfilament Proteins - analysis Microfilament Proteins - antagonists & inhibitors Microfilament Proteins - physiology Molecular Medicine Oncology Pancreatic cancer Pancreatic Neoplasms - pathology Phenotypes Proteins Proteomes Tumorigenesis Tumors Ubiquitin-Specific Peptidase 7 - physiology Ubiquitination Western blotting Wnt protein Wnt Signaling Pathway - physiology β-Catenin
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