Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients
Sleep disorders are common non-motor symptoms in patients with Parkinson’s disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with mo...
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| Veröffentlicht in: | NPJ Parkinson's Disease 2020-09, Vol.6 (1), p.25-25, Article 25 |
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| creator | Zhang, Yu Zhao, Jia hao Huang, Dong ya Chen, Wei Yuan, Can xing Jin, Li rong Wang, Yu hui Jin, Ling jing Lu, Lei Wang, Xiao ping de Wang, Chang Zhao, Xiao hui Zhang, Xi Li, Wen tao Liu, Zhen guo |
| description | Sleep disorders are common non-motor symptoms in patients with Parkinson’s disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. In this multicenter, observational, cross-sectional study, data concerning the clinical characteristics of complicated sleep disorders were collected from PD patients treated at 40 different hospitals in Shanghai. Sleep disorders were evaluated using the PD Sleep Scale-2, Epworth Sleepiness Scale, Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong, and the International Restless Legs Scale. Among the 1006 subjects evaluated, 77.53% exhibited signs of sleep disorders, and most had multiple sleep disorders (
n
= 502, 49.9%). A smaller percentage of patients with sleep disorders had a single disorder (
n
= 278, 27.6%). Furthermore, an increased number of sleep disorders, including nighttime problems, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, and restless legs syndrome was a significant contributor to a poor quality of life (
β
= 4.33, CI: 3.33–5.33,
P
for trend |
| doi_str_mv | 10.1038/s41531-020-00126-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7492275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2442691943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-81024c6b7f4319bbf79a86bfe67779fb18e27e8de471beb67b71f5450e5b3b183</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EolXpC7BAltiwCfg3TjZIqCo_UhEsYG3Zybi4-MapJ6l6d7wGr8eT4MstpbBgNZbOd854dAh5zNlzzmT3AhXXkjdMsIYxLtrm-h45FNLIpmPa3L_zPiDHiBesUqrtes0ekgMpWXVrdUjG92ta4pyADnmTi48jxQQw0zFiLiMUpG68qgPSlroQYFjo5epSXLY0B5piABon-tGVr3HCPP349h13XnAIdHZLhGnBR-RBcAnh-GYekc-vTz-dvG3OPrx5d_LqrBm0YkvTcSbU0HoTlOS998H0rmt9gNYY0wfPOxAGuhGU4R58a7zhQSvNQHtZVXlEXu5z59VvYBzq7uKSnUvcuLK12UX7tzLFL_Y8X1mjeiGMrgHPbgJKvlwBF7uJOEBKboK8ohVKda3inPGKPv0Hvchrmep5O0q0Pe-VrJTYU0PJiAXC7Wc4s7se7b5HW3u0v3q019X05O4Zt5bfrVVA7gGs0nQO5c_u_8T-BBiSq90</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2442691943</pqid></control><display><type>article</type><title>Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients</title><source>Nature Free</source><source>Springer_OA刊</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Zhang, Yu ; Zhao, Jia hao ; Huang, Dong ya ; Chen, Wei ; Yuan, Can xing ; Jin, Li rong ; Wang, Yu hui ; Jin, Ling jing ; Lu, Lei ; Wang, Xiao ping ; de Wang, Chang ; Zhao, Xiao hui ; Zhang, Xi ; Li, Wen tao ; Liu, Zhen guo</creator><creatorcontrib>Zhang, Yu ; Zhao, Jia hao ; Huang, Dong ya ; Chen, Wei ; Yuan, Can xing ; Jin, Li rong ; Wang, Yu hui ; Jin, Ling jing ; Lu, Lei ; Wang, Xiao ping ; de Wang, Chang ; Zhao, Xiao hui ; Zhang, Xi ; Li, Wen tao ; Liu, Zhen guo</creatorcontrib><description>Sleep disorders are common non-motor symptoms in patients with Parkinson’s disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. In this multicenter, observational, cross-sectional study, data concerning the clinical characteristics of complicated sleep disorders were collected from PD patients treated at 40 different hospitals in Shanghai. Sleep disorders were evaluated using the PD Sleep Scale-2, Epworth Sleepiness Scale, Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong, and the International Restless Legs Scale. Among the 1006 subjects evaluated, 77.53% exhibited signs of sleep disorders, and most had multiple sleep disorders (
n
= 502, 49.9%). A smaller percentage of patients with sleep disorders had a single disorder (
n
= 278, 27.6%). Furthermore, an increased number of sleep disorders, including nighttime problems, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, and restless legs syndrome was a significant contributor to a poor quality of life (
β
= 4.33, CI: 3.33–5.33,
P
for trend <0.001), even when controlling for multiple factors. Moreover, motor complications partially mediated this relationship (indirect effect:
β
= 0.355, 95% boot CI: 0.134, 0.652).Our study showed that a large proportion of PD patients suffer from multiple comorbid sleep disorders, which greatly decreases the quality of life in PD patients and is partially mediated by motor complications.</description><identifier>ISSN: 2373-8057</identifier><identifier>EISSN: 2373-8057</identifier><identifier>DOI: 10.1038/s41531-020-00126-x</identifier><identifier>PMID: 33015354</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/375/1718 ; 692/699/375/346/1718 ; Behavior disorders ; Biomedical and Life Sciences ; Biomedicine ; Comorbidity ; Eye movements ; Neurology ; Neurosciences ; Parkinson's disease ; Quality of life ; REM sleep ; Restless legs syndrome ; Sleep disorders</subject><ispartof>NPJ Parkinson's Disease, 2020-09, Vol.6 (1), p.25-25, Article 25</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020.</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-81024c6b7f4319bbf79a86bfe67779fb18e27e8de471beb67b71f5450e5b3b183</citedby><cites>FETCH-LOGICAL-c540t-81024c6b7f4319bbf79a86bfe67779fb18e27e8de471beb67b71f5450e5b3b183</cites><orcidid>0000-0002-2936-5877 ; 0000-0002-4528-2879</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492275/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492275/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33015354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zhao, Jia hao</creatorcontrib><creatorcontrib>Huang, Dong ya</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Yuan, Can xing</creatorcontrib><creatorcontrib>Jin, Li rong</creatorcontrib><creatorcontrib>Wang, Yu hui</creatorcontrib><creatorcontrib>Jin, Ling jing</creatorcontrib><creatorcontrib>Lu, Lei</creatorcontrib><creatorcontrib>Wang, Xiao ping</creatorcontrib><creatorcontrib>de Wang, Chang</creatorcontrib><creatorcontrib>Zhao, Xiao hui</creatorcontrib><creatorcontrib>Zhang, Xi</creatorcontrib><creatorcontrib>Li, Wen tao</creatorcontrib><creatorcontrib>Liu, Zhen guo</creatorcontrib><title>Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients</title><title>NPJ Parkinson's Disease</title><addtitle>npj Parkinsons Dis</addtitle><addtitle>NPJ Parkinsons Dis</addtitle><description>Sleep disorders are common non-motor symptoms in patients with Parkinson’s disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. In this multicenter, observational, cross-sectional study, data concerning the clinical characteristics of complicated sleep disorders were collected from PD patients treated at 40 different hospitals in Shanghai. Sleep disorders were evaluated using the PD Sleep Scale-2, Epworth Sleepiness Scale, Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong, and the International Restless Legs Scale. Among the 1006 subjects evaluated, 77.53% exhibited signs of sleep disorders, and most had multiple sleep disorders (
n
= 502, 49.9%). A smaller percentage of patients with sleep disorders had a single disorder (
n
= 278, 27.6%). Furthermore, an increased number of sleep disorders, including nighttime problems, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, and restless legs syndrome was a significant contributor to a poor quality of life (
β
= 4.33, CI: 3.33–5.33,
P
for trend <0.001), even when controlling for multiple factors. Moreover, motor complications partially mediated this relationship (indirect effect:
β
= 0.355, 95% boot CI: 0.134, 0.652).Our study showed that a large proportion of PD patients suffer from multiple comorbid sleep disorders, which greatly decreases the quality of life in PD patients and is partially mediated by motor complications.</description><subject>692/699/375/1718</subject><subject>692/699/375/346/1718</subject><subject>Behavior disorders</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Comorbidity</subject><subject>Eye movements</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Parkinson's disease</subject><subject>Quality of life</subject><subject>REM sleep</subject><subject>Restless legs syndrome</subject><subject>Sleep disorders</subject><issn>2373-8057</issn><issn>2373-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kc1u1TAQhS0EolXpC7BAltiwCfg3TjZIqCo_UhEsYG3Zybi4-MapJ6l6d7wGr8eT4MstpbBgNZbOd854dAh5zNlzzmT3AhXXkjdMsIYxLtrm-h45FNLIpmPa3L_zPiDHiBesUqrtes0ekgMpWXVrdUjG92ta4pyADnmTi48jxQQw0zFiLiMUpG68qgPSlroQYFjo5epSXLY0B5piABon-tGVr3HCPP349h13XnAIdHZLhGnBR-RBcAnh-GYekc-vTz-dvG3OPrx5d_LqrBm0YkvTcSbU0HoTlOS998H0rmt9gNYY0wfPOxAGuhGU4R58a7zhQSvNQHtZVXlEXu5z59VvYBzq7uKSnUvcuLK12UX7tzLFL_Y8X1mjeiGMrgHPbgJKvlwBF7uJOEBKboK8ohVKda3inPGKPv0Hvchrmep5O0q0Pe-VrJTYU0PJiAXC7Wc4s7se7b5HW3u0v3q019X05O4Zt5bfrVVA7gGs0nQO5c_u_8T-BBiSq90</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>Zhang, Yu</creator><creator>Zhao, Jia hao</creator><creator>Huang, Dong ya</creator><creator>Chen, Wei</creator><creator>Yuan, Can xing</creator><creator>Jin, Li rong</creator><creator>Wang, Yu hui</creator><creator>Jin, Ling jing</creator><creator>Lu, Lei</creator><creator>Wang, Xiao ping</creator><creator>de Wang, Chang</creator><creator>Zhao, Xiao hui</creator><creator>Zhang, Xi</creator><creator>Li, Wen tao</creator><creator>Liu, Zhen guo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2936-5877</orcidid><orcidid>https://orcid.org/0000-0002-4528-2879</orcidid></search><sort><creationdate>20200915</creationdate><title>Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients</title><author>Zhang, Yu ; Zhao, Jia hao ; Huang, Dong ya ; Chen, Wei ; Yuan, Can xing ; Jin, Li rong ; Wang, Yu hui ; Jin, Ling jing ; Lu, Lei ; Wang, Xiao ping ; de Wang, Chang ; Zhao, Xiao hui ; Zhang, Xi ; Li, Wen tao ; Liu, Zhen guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-81024c6b7f4319bbf79a86bfe67779fb18e27e8de471beb67b71f5450e5b3b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/699/375/1718</topic><topic>692/699/375/346/1718</topic><topic>Behavior disorders</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Comorbidity</topic><topic>Eye movements</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Parkinson's disease</topic><topic>Quality of life</topic><topic>REM sleep</topic><topic>Restless legs syndrome</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zhao, Jia hao</creatorcontrib><creatorcontrib>Huang, Dong ya</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Yuan, Can xing</creatorcontrib><creatorcontrib>Jin, Li rong</creatorcontrib><creatorcontrib>Wang, Yu hui</creatorcontrib><creatorcontrib>Jin, Ling jing</creatorcontrib><creatorcontrib>Lu, Lei</creatorcontrib><creatorcontrib>Wang, Xiao ping</creatorcontrib><creatorcontrib>de Wang, Chang</creatorcontrib><creatorcontrib>Zhao, Xiao hui</creatorcontrib><creatorcontrib>Zhang, Xi</creatorcontrib><creatorcontrib>Li, Wen tao</creatorcontrib><creatorcontrib>Liu, Zhen guo</creatorcontrib><collection>Springer_OA刊</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NPJ Parkinson's Disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yu</au><au>Zhao, Jia hao</au><au>Huang, Dong ya</au><au>Chen, Wei</au><au>Yuan, Can xing</au><au>Jin, Li rong</au><au>Wang, Yu hui</au><au>Jin, Ling jing</au><au>Lu, Lei</au><au>Wang, Xiao ping</au><au>de Wang, Chang</au><au>Zhao, Xiao hui</au><au>Zhang, Xi</au><au>Li, Wen tao</au><au>Liu, Zhen guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients</atitle><jtitle>NPJ Parkinson's Disease</jtitle><stitle>npj Parkinsons Dis</stitle><addtitle>NPJ Parkinsons Dis</addtitle><date>2020-09-15</date><risdate>2020</risdate><volume>6</volume><issue>1</issue><spage>25</spage><epage>25</epage><pages>25-25</pages><artnum>25</artnum><issn>2373-8057</issn><eissn>2373-8057</eissn><abstract>Sleep disorders are common non-motor symptoms in patients with Parkinson’s disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. In this multicenter, observational, cross-sectional study, data concerning the clinical characteristics of complicated sleep disorders were collected from PD patients treated at 40 different hospitals in Shanghai. Sleep disorders were evaluated using the PD Sleep Scale-2, Epworth Sleepiness Scale, Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong, and the International Restless Legs Scale. Among the 1006 subjects evaluated, 77.53% exhibited signs of sleep disorders, and most had multiple sleep disorders (
n
= 502, 49.9%). A smaller percentage of patients with sleep disorders had a single disorder (
n
= 278, 27.6%). Furthermore, an increased number of sleep disorders, including nighttime problems, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, and restless legs syndrome was a significant contributor to a poor quality of life (
β
= 4.33, CI: 3.33–5.33,
P
for trend <0.001), even when controlling for multiple factors. Moreover, motor complications partially mediated this relationship (indirect effect:
β
= 0.355, 95% boot CI: 0.134, 0.652).Our study showed that a large proportion of PD patients suffer from multiple comorbid sleep disorders, which greatly decreases the quality of life in PD patients and is partially mediated by motor complications.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33015354</pmid><doi>10.1038/s41531-020-00126-x</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2936-5877</orcidid><orcidid>https://orcid.org/0000-0002-4528-2879</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | NPJ Parkinson's Disease, 2020-09, Vol.6 (1), p.25-25, Article 25 |
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| source | Nature Free; Springer_OA刊; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | 692/699/375/1718 692/699/375/346/1718 Behavior disorders Biomedical and Life Sciences Biomedicine Comorbidity Eye movements Neurology Neurosciences Parkinson's disease Quality of life REM sleep Restless legs syndrome Sleep disorders |
| title | Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients |
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