Predictive factors for prognosis after gastrostomy placement in routine non-invasive ventilation users ALS patients
Due to the expanding use of non-invasive ventilation (NIV) in amyotrophic lateral sclerosis (ALS), the question of enteral nutrition is increasingly raised in NIV users ALS patients. Here, we aimed to determine the prognostic factors for survival after gastrostomy placement in routine NIV users, tak...
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| Veröffentlicht in: | Scientific reports 2020-09, Vol.10 (1), p.15117-15117, Article 15117 |
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| creator | Hesters, Adèle Amador, Maria del Mar Debs, Rabab Le Forestier, Nadine Lenglet, Timothée Pradat, Pierre-François Salachas, François Faure, Morgane Jimenez, Maria-Alejandra Galarza Gonzalez-Bermejo, Jesus Morelot, Capucine Bruneteau, Gaëlle |
| description | Due to the expanding use of non-invasive ventilation (NIV) in amyotrophic lateral sclerosis (ALS), the question of enteral nutrition is increasingly raised in NIV users ALS patients. Here, we aimed to determine the prognostic factors for survival after gastrostomy placement in routine NIV users, taking into consideration ventilator dependence. Ninety-two routine NIV users ALS patients, who underwent gastrostomy insertion for severe dysphagia and/or weight loss, were included. We used a Cox proportional hazards model to identify factors affecting survival and compared time from gastrostomy to death and 30-day mortality rate between dependent (daily use ≥ 16 h) and non-dependent NIV users. The hazard of death after gastrostomy was significantly affected by 3 factors: age at onset (HR 1.047,
p
= 0.006), body mass index |
| doi_str_mv | 10.1038/s41598-020-70422-2 |
| format | Article |
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p
= 0.006), body mass index < 20 kg/m
2
at the time of gastrostomy placement (HR 2.012,
p
= 0.016) and recurrent accumulation of airway secretions (HR 2.614,
p
= 0.001). Mean time from gastrostomy to death was significantly shorter in the dependent than in the non-dependent NIV users group (133 vs. 250 days,
p
= 0.04). The 30-day mortality rate was significantly higher in dependent NIV users (21.4% vs. 2.8%,
p
= 0.03). Pre-operative ventilator dependence and airway secretion accumulation are associated with worse prognosis and should be key decision-making criteria when considering gastrostomy tube placement in NIV users ALS patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-70422-2</identifier><identifier>PMID: 32934263</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/1807/1809 ; 692/617/375/1917/1285 ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis - pathology ; Amyotrophic Lateral Sclerosis - surgery ; Female ; Follow-Up Studies ; Gastrostomy - methods ; Humanities and Social Sciences ; Humans ; Life Sciences ; Male ; Middle Aged ; multidisciplinary ; Noninvasive Ventilation - methods ; Prognosis ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Vital Capacity ; Young Adult</subject><ispartof>Scientific reports, 2020-09, Vol.10 (1), p.15117-15117, Article 15117</ispartof><rights>The Author(s) 2020</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-d12a18098259d9261b1ab4f14774aea8f3b4a1fb9e79fb8c0ba1362ebbb534723</citedby><cites>FETCH-LOGICAL-c480t-d12a18098259d9261b1ab4f14774aea8f3b4a1fb9e79fb8c0ba1362ebbb534723</cites><orcidid>0000-0002-1905-7985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492246/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492246/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32934263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-02969094$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Hesters, Adèle</creatorcontrib><creatorcontrib>Amador, Maria del Mar</creatorcontrib><creatorcontrib>Debs, Rabab</creatorcontrib><creatorcontrib>Le Forestier, Nadine</creatorcontrib><creatorcontrib>Lenglet, Timothée</creatorcontrib><creatorcontrib>Pradat, Pierre-François</creatorcontrib><creatorcontrib>Salachas, François</creatorcontrib><creatorcontrib>Faure, Morgane</creatorcontrib><creatorcontrib>Jimenez, Maria-Alejandra Galarza</creatorcontrib><creatorcontrib>Gonzalez-Bermejo, Jesus</creatorcontrib><creatorcontrib>Morelot, Capucine</creatorcontrib><creatorcontrib>Bruneteau, Gaëlle</creatorcontrib><title>Predictive factors for prognosis after gastrostomy placement in routine non-invasive ventilation users ALS patients</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Due to the expanding use of non-invasive ventilation (NIV) in amyotrophic lateral sclerosis (ALS), the question of enteral nutrition is increasingly raised in NIV users ALS patients. Here, we aimed to determine the prognostic factors for survival after gastrostomy placement in routine NIV users, taking into consideration ventilator dependence. Ninety-two routine NIV users ALS patients, who underwent gastrostomy insertion for severe dysphagia and/or weight loss, were included. We used a Cox proportional hazards model to identify factors affecting survival and compared time from gastrostomy to death and 30-day mortality rate between dependent (daily use ≥ 16 h) and non-dependent NIV users. The hazard of death after gastrostomy was significantly affected by 3 factors: age at onset (HR 1.047,
p
= 0.006), body mass index < 20 kg/m
2
at the time of gastrostomy placement (HR 2.012,
p
= 0.016) and recurrent accumulation of airway secretions (HR 2.614,
p
= 0.001). Mean time from gastrostomy to death was significantly shorter in the dependent than in the non-dependent NIV users group (133 vs. 250 days,
p
= 0.04). The 30-day mortality rate was significantly higher in dependent NIV users (21.4% vs. 2.8%,
p
= 0.03). Pre-operative ventilator dependence and airway secretion accumulation are associated with worse prognosis and should be key decision-making criteria when considering gastrostomy tube placement in NIV users ALS patients.</description><subject>692/1807/1809</subject><subject>692/617/375/1917/1285</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Amyotrophic Lateral Sclerosis - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrostomy - methods</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Noninvasive Ventilation - methods</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vital Capacity</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU9rFTEUxYMottR-AReSpS5Gk5vMn2yER1ErPFBQ1yGZl3lNmUnG3MxAv715Ti3Vhdkk3HPyu9x7CHnJ2VvORPcOJa9VVzFgVcskQAVPyDkwWVcgAJ4-ep-RS8RbVk4NSnL1nJwJUEJCI84Jfk3u4PvsV0cH0-eYkA4x0TnFY4jokZohu0SPBnOKmON0R-fR9G5yIVMfaIpL9sHREEPlw2rwRFqL6EeTfQx0QVeYu_03OpdCEfAFeTaYEd3l_X1Bfnz88P3qutp_-fT5arevetmxXB04GN4x1UGtDgoabrmxcuCybaVxphuElYYPVrlWDbbrmTVcNOCstbWQLYgL8n7jzoud3KEvvZMZ9Zz8ZNKdjsbrv5Xgb_QxrrqVCkA2BfBmA9z88-16t9enGgPVKKbkyov39X2zFH8uDrOePPZuHE1wcUENUooaRN3IYoXN2peNYnLDA5szfQpXb-EWPNO_w9WnYV49Hubhy58oi0FsBixSOLqkb-OSQlnw_7C_ACL6sos</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>Hesters, Adèle</creator><creator>Amador, Maria del Mar</creator><creator>Debs, Rabab</creator><creator>Le Forestier, Nadine</creator><creator>Lenglet, Timothée</creator><creator>Pradat, Pierre-François</creator><creator>Salachas, François</creator><creator>Faure, Morgane</creator><creator>Jimenez, Maria-Alejandra Galarza</creator><creator>Gonzalez-Bermejo, Jesus</creator><creator>Morelot, Capucine</creator><creator>Bruneteau, Gaëlle</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1905-7985</orcidid></search><sort><creationdate>20200915</creationdate><title>Predictive factors for prognosis after gastrostomy placement in routine non-invasive ventilation users ALS patients</title><author>Hesters, Adèle ; Amador, Maria del Mar ; Debs, Rabab ; Le Forestier, Nadine ; Lenglet, Timothée ; Pradat, Pierre-François ; Salachas, François ; Faure, Morgane ; Jimenez, Maria-Alejandra Galarza ; Gonzalez-Bermejo, Jesus ; Morelot, Capucine ; Bruneteau, Gaëlle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-d12a18098259d9261b1ab4f14774aea8f3b4a1fb9e79fb8c0ba1362ebbb534723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/1807/1809</topic><topic>692/617/375/1917/1285</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Amyotrophic Lateral Sclerosis - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrostomy - methods</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Noninvasive Ventilation - methods</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vital Capacity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hesters, Adèle</creatorcontrib><creatorcontrib>Amador, Maria del Mar</creatorcontrib><creatorcontrib>Debs, Rabab</creatorcontrib><creatorcontrib>Le Forestier, Nadine</creatorcontrib><creatorcontrib>Lenglet, Timothée</creatorcontrib><creatorcontrib>Pradat, Pierre-François</creatorcontrib><creatorcontrib>Salachas, François</creatorcontrib><creatorcontrib>Faure, Morgane</creatorcontrib><creatorcontrib>Jimenez, Maria-Alejandra Galarza</creatorcontrib><creatorcontrib>Gonzalez-Bermejo, Jesus</creatorcontrib><creatorcontrib>Morelot, Capucine</creatorcontrib><creatorcontrib>Bruneteau, Gaëlle</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hesters, Adèle</au><au>Amador, Maria del Mar</au><au>Debs, Rabab</au><au>Le Forestier, Nadine</au><au>Lenglet, Timothée</au><au>Pradat, Pierre-François</au><au>Salachas, François</au><au>Faure, Morgane</au><au>Jimenez, Maria-Alejandra Galarza</au><au>Gonzalez-Bermejo, Jesus</au><au>Morelot, Capucine</au><au>Bruneteau, Gaëlle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive factors for prognosis after gastrostomy placement in routine non-invasive ventilation users ALS patients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-09-15</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>15117</spage><epage>15117</epage><pages>15117-15117</pages><artnum>15117</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Due to the expanding use of non-invasive ventilation (NIV) in amyotrophic lateral sclerosis (ALS), the question of enteral nutrition is increasingly raised in NIV users ALS patients. Here, we aimed to determine the prognostic factors for survival after gastrostomy placement in routine NIV users, taking into consideration ventilator dependence. Ninety-two routine NIV users ALS patients, who underwent gastrostomy insertion for severe dysphagia and/or weight loss, were included. We used a Cox proportional hazards model to identify factors affecting survival and compared time from gastrostomy to death and 30-day mortality rate between dependent (daily use ≥ 16 h) and non-dependent NIV users. The hazard of death after gastrostomy was significantly affected by 3 factors: age at onset (HR 1.047,
p
= 0.006), body mass index < 20 kg/m
2
at the time of gastrostomy placement (HR 2.012,
p
= 0.016) and recurrent accumulation of airway secretions (HR 2.614,
p
= 0.001). Mean time from gastrostomy to death was significantly shorter in the dependent than in the non-dependent NIV users group (133 vs. 250 days,
p
= 0.04). The 30-day mortality rate was significantly higher in dependent NIV users (21.4% vs. 2.8%,
p
= 0.03). Pre-operative ventilator dependence and airway secretion accumulation are associated with worse prognosis and should be key decision-making criteria when considering gastrostomy tube placement in NIV users ALS patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32934263</pmid><doi>10.1038/s41598-020-70422-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1905-7985</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/1807/1809 692/617/375/1917/1285 Adolescent Adult Aged Aged, 80 and over Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - surgery Female Follow-Up Studies Gastrostomy - methods Humanities and Social Sciences Humans Life Sciences Male Middle Aged multidisciplinary Noninvasive Ventilation - methods Prognosis Retrospective Studies Science Science (multidisciplinary) Vital Capacity Young Adult |
| title | Predictive factors for prognosis after gastrostomy placement in routine non-invasive ventilation users ALS patients |
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