Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome

Background The recent emergence of COVID-19 poses a global health emergency. One of the most frequently reported data is sex-related severity and mortality: according to the last available analysis on 239,709 patients in Italy, lethality is 17.7% in men and 10.8% in women, with 59% of total deaths b...

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Veröffentlicht in:	Journal of endocrinological investigation 2021-05, Vol.44 (5), p.951-956
Hauptverfasser:	Foresta, C., Rocca, M. S., Di Nisio, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Androgens Angiotensin Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - blood Angiotensin-Converting Enzyme 2 - genetics Chromosomes, Human, X - genetics Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - genetics Endocrinology Estrogens Female Gender Genetic Predisposition to Disease - epidemiology Gonadal Steroid Hormones Hormones Humans Infections Internal Medicine Lethality Male Medicine Medicine & Public Health Metabolic Diseases Peptidyl-dipeptidase A Public health Serine Serine Endopeptidases - blood Serine Endopeptidases - genetics Serine proteinase Severe acute respiratory syndrome coronavirus 2 Sex Characteristics Sex chromosomes Sex differences Sex Factors Sex hormones Short Review Women X chromosomes X-chromosome inactivation
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