Inhibition of microRNA-128-3p alleviates liver ischaemia–reperfusion injury in mice through repressing the Rnd3/NF‐κB axis

Although liver ischaemia–reperfusion (I/R) injury remains the primary underlying reason for liver transplant failure or post-transplantation liver dysfunction, the underlying mechanism is still largely elusive. MicroRNAs (miRNA) are involved in multiple physiological and pathological processes, incl...

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Veröffentlicht in:	Innate immunity (London, England) England), 2020-08, Vol.26 (6), p.528-536
Hauptverfasser:	Mou, Tong, Luo, Yunhai, Huang, Zuotian, Zheng, Daofeng, Pu, Xingyu, Shen, Ai, Pu, Junliang, Li, Tingting, Dai, Jiangwen, Chen, Wei, Wu, Zhongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Alanine Transaminase - blood Animals Aspartate aminotransferase Aspartate Aminotransferases - blood Gene Expression Regulation Gene Knockdown Techniques Guanosine triphosphatases Humans Inflammation Inflammation - genetics Inflammation - metabolism Ischemia Liver Liver - metabolism Liver - pathology Liver diseases Liver transplantation Male Mice Mice, Inbred C57BL MicroRNAs MicroRNAs - genetics miRNA mRNA NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Original Polymerase chain reaction Reperfusion Reperfusion Injury - genetics Reperfusion Injury - metabolism Reperfusion Injury - prevention & control rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism Serum levels Signal Transduction Transplants & implants Western blotting
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