MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

Although ferroptosis has been recognized as a novel antitumoral treatment, high expression of nuclear factor erythroid 2-related factor 2 (NRF2) has been reported to be an antioxidant transcript factor that protects malignant cells from ferroptosis. Previous findings indicated that metallothionein 1...

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Veröffentlicht in:	Cell death & disease 2020-09, Vol.11 (9), p.751-751, Article 751
Hauptverfasser:	Gai, Chengcheng, Liu, Chuanliang, Wu, Xinghan, Yu, Mengyu, Zheng, Jie, Zhang, Weifen, Lv, Shijun, Li, Wentong
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 13/31 14/34 38/1 631/67 631/80 64/60 Animals Antibodies Antioxidants Bioavailability Biochemistry Biomedical and Life Sciences Carcinoma, Non-Small-Cell Lung - drug therapy Cell Biology Cell Culture Cell Line, Tumor Cell Proliferation Ectopic expression Ferroptosis Ferroptosis - drug effects Folic acid Glutathione Humans Immunology Life Sciences Lipopolysaccharides Liposomes Liposomes - metabolism Lung cancer Lung Neoplasms - drug therapy Malondialdehyde Metallothionein Mice Nanoparticles NF-E2-Related Factor 2 - drug effects Non-small cell lung carcinoma Oxidative stress Piperazines - pharmacology Piperazines - therapeutic use Reactive oxygen species Ribonucleic acid RNA Small cell lung carcinoma Transcription Transfection Xenografts
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