Arylsulfonyl histamine derivatives as powerful and selective α-glucosidase inhibitors

A series of simple N -arylbenzenesulfonyl histamine derivatives were prepared and screened against α-glucosidase. Inhibition was in the micromolar range for several N α , N τ -di-arylsulfonyl compounds, with N α , N τ -di-4-trifluorobenzenesulfonyl histamine ( IId ) being the best inhibitor. Compoun...

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