Chronic pancreatitis in farmed pigs fed excessive zinc oxide
Most of the pigs on a farm in Aichi Prefecture, Japan had chronic diarrhea and severe wasting. The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct–l...
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| Veröffentlicht in: | Journal of veterinary diagnostic investigation 2020-09, Vol.32 (5), p.689-694 |
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| creator | Komatsu, Tetsuya Sugie, Kennosuke Inukai, Naoko Eguchi, Osamu Oyamada, Toshifumi Sawada, Hiroshi Yamanaka, Noriko Shibahara, Tomoyuki |
| description | Most of the pigs on a farm in Aichi Prefecture, Japan had chronic diarrhea and severe wasting. The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct–like cells were increased and tested positive for cytokeratin AE1/AE3, Ki67, PGP9.5, and Sox9. Pancreatic islet cells were decreased and shrunken. The α and δ cells were relatively decreased, and their distribution was abnormal. Islet cells were positive for PGP9.5. The livers and kidneys had high accumulations of zinc (Zn; 788 µg/g and 613 µg/g, respectively). Copper was deficient in the liver, likely as a result of Zn poisoning. Our immunohistologic examination suggested that the high dose of ZnO could influence the function of islet cells in addition to that of acinar cells. Given that colistin sulfate has been banned as a feed additive in order to reduce antimicrobial use in Japan, the use of ZnO in the livestock industry is expected to increase. Zn supplementation of pig feed must be monitored to prevent Zn poisoning and contamination of soil and water. |
| doi_str_mv | 10.1177/1040638720944368 |
| format | Article |
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The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct–like cells were increased and tested positive for cytokeratin AE1/AE3, Ki67, PGP9.5, and Sox9. Pancreatic islet cells were decreased and shrunken. The α and δ cells were relatively decreased, and their distribution was abnormal. Islet cells were positive for PGP9.5. The livers and kidneys had high accumulations of zinc (Zn; 788 µg/g and 613 µg/g, respectively). Copper was deficient in the liver, likely as a result of Zn poisoning. Our immunohistologic examination suggested that the high dose of ZnO could influence the function of islet cells in addition to that of acinar cells. Given that colistin sulfate has been banned as a feed additive in order to reduce antimicrobial use in Japan, the use of ZnO in the livestock industry is expected to increase. Zn supplementation of pig feed must be monitored to prevent Zn poisoning and contamination of soil and water.</description><identifier>ISSN: 1040-6387</identifier><identifier>EISSN: 1943-4936</identifier><identifier>DOI: 10.1177/1040638720944368</identifier><identifier>PMID: 32715990</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animal Husbandry ; Animals ; Brief Communication ; Copper - deficiency ; Female ; Japan ; Kidney - chemistry ; Liver - chemistry ; Pancreatitis, Chronic - chemically induced ; Pancreatitis, Chronic - metabolism ; Pancreatitis, Chronic - pathology ; Pancreatitis, Chronic - veterinary ; Sus scrofa ; Swine ; Swine Diseases - chemically induced ; Swine Diseases - metabolism ; Swine Diseases - pathology ; Zinc - poisoning ; Zinc - toxicity ; Zinc Oxide - poisoning ; Zinc Oxide - toxicity</subject><ispartof>Journal of veterinary diagnostic investigation, 2020-09, Vol.32 (5), p.689-694</ispartof><rights>2020 The Author(s)</rights><rights>2020 The Author(s) 2020 American Association of Veterinary Laboratory Diagnosticians</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-20c10717d0ad92802078fb12c0d700c2bdfb40d9b065081751b31883e89855803</citedby><cites>FETCH-LOGICAL-c434t-20c10717d0ad92802078fb12c0d700c2bdfb40d9b065081751b31883e89855803</cites><orcidid>0000-0001-9335-5596</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488960/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488960/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21798,27901,27902,43597,43598,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32715990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komatsu, Tetsuya</creatorcontrib><creatorcontrib>Sugie, Kennosuke</creatorcontrib><creatorcontrib>Inukai, Naoko</creatorcontrib><creatorcontrib>Eguchi, Osamu</creatorcontrib><creatorcontrib>Oyamada, Toshifumi</creatorcontrib><creatorcontrib>Sawada, Hiroshi</creatorcontrib><creatorcontrib>Yamanaka, Noriko</creatorcontrib><creatorcontrib>Shibahara, Tomoyuki</creatorcontrib><title>Chronic pancreatitis in farmed pigs fed excessive zinc oxide</title><title>Journal of veterinary diagnostic investigation</title><addtitle>J Vet Diagn Invest</addtitle><description>Most of the pigs on a farm in Aichi Prefecture, Japan had chronic diarrhea and severe wasting. The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct–like cells were increased and tested positive for cytokeratin AE1/AE3, Ki67, PGP9.5, and Sox9. Pancreatic islet cells were decreased and shrunken. The α and δ cells were relatively decreased, and their distribution was abnormal. Islet cells were positive for PGP9.5. The livers and kidneys had high accumulations of zinc (Zn; 788 µg/g and 613 µg/g, respectively). Copper was deficient in the liver, likely as a result of Zn poisoning. Our immunohistologic examination suggested that the high dose of ZnO could influence the function of islet cells in addition to that of acinar cells. Given that colistin sulfate has been banned as a feed additive in order to reduce antimicrobial use in Japan, the use of ZnO in the livestock industry is expected to increase. Zn supplementation of pig feed must be monitored to prevent Zn poisoning and contamination of soil and water.</description><subject>Animal Husbandry</subject><subject>Animals</subject><subject>Brief Communication</subject><subject>Copper - deficiency</subject><subject>Female</subject><subject>Japan</subject><subject>Kidney - chemistry</subject><subject>Liver - chemistry</subject><subject>Pancreatitis, Chronic - chemically induced</subject><subject>Pancreatitis, Chronic - metabolism</subject><subject>Pancreatitis, Chronic - pathology</subject><subject>Pancreatitis, Chronic - veterinary</subject><subject>Sus scrofa</subject><subject>Swine</subject><subject>Swine Diseases - chemically induced</subject><subject>Swine Diseases - metabolism</subject><subject>Swine Diseases - pathology</subject><subject>Zinc - poisoning</subject><subject>Zinc - toxicity</subject><subject>Zinc Oxide - poisoning</subject><subject>Zinc Oxide - toxicity</subject><issn>1040-6387</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEQx4MotlbvniRfYHXy2iQggpT6gIIXPYdsNtumtLtLsi3VT--WalHB0wz8HzP8ELokcE2IlDcEOORMSQqac5arIzQkmrOMa5Yf93svZzt9gM5SWgAIKiQ5RQNGJRFawxDdjuexqYPDra1d9LYLXUg41LiyceVL3IZZwlW_-K3zKYWNxx-hdrjZhtKfo5PKLpO_-Joj9PYweR0_ZdOXx-fx_TRznPEuo-AISCJLsKWmCihIVRWEOiglgKNFWRUcSl1ALkARKUjBiFLMK62EUMBG6G7f266L_inn6y7apWljWNn4bhobzG-lDnMzazZGcqV0viuAfYGLTUrRV4csAbMjaf6S7CNXP28eAt_oekO2NyQ782bRrGPdM_i_8BO3f3q_</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Komatsu, Tetsuya</creator><creator>Sugie, Kennosuke</creator><creator>Inukai, Naoko</creator><creator>Eguchi, Osamu</creator><creator>Oyamada, Toshifumi</creator><creator>Sawada, Hiroshi</creator><creator>Yamanaka, Noriko</creator><creator>Shibahara, Tomoyuki</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9335-5596</orcidid></search><sort><creationdate>20200901</creationdate><title>Chronic pancreatitis in farmed pigs fed excessive zinc oxide</title><author>Komatsu, Tetsuya ; 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The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct–like cells were increased and tested positive for cytokeratin AE1/AE3, Ki67, PGP9.5, and Sox9. Pancreatic islet cells were decreased and shrunken. The α and δ cells were relatively decreased, and their distribution was abnormal. Islet cells were positive for PGP9.5. The livers and kidneys had high accumulations of zinc (Zn; 788 µg/g and 613 µg/g, respectively). Copper was deficient in the liver, likely as a result of Zn poisoning. Our immunohistologic examination suggested that the high dose of ZnO could influence the function of islet cells in addition to that of acinar cells. Given that colistin sulfate has been banned as a feed additive in order to reduce antimicrobial use in Japan, the use of ZnO in the livestock industry is expected to increase. 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| source | SAGE Complete A-Z List; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animal Husbandry Animals Brief Communication Copper - deficiency Female Japan Kidney - chemistry Liver - chemistry Pancreatitis, Chronic - chemically induced Pancreatitis, Chronic - metabolism Pancreatitis, Chronic - pathology Pancreatitis, Chronic - veterinary Sus scrofa Swine Swine Diseases - chemically induced Swine Diseases - metabolism Swine Diseases - pathology Zinc - poisoning Zinc - toxicity Zinc Oxide - poisoning Zinc Oxide - toxicity |
| title | Chronic pancreatitis in farmed pigs fed excessive zinc oxide |
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