Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles

Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P1 differentiated modulators 3–6. The effects of analogs 3–6 on lymphocyte reduction in the rat (desired pharmacology) along with...

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Veröffentlicht in:	ACS medicinal chemistry letters 2020-09, Vol.11 (9), p.1766-1772
Hauptverfasser:	Xiao, Zili, Yang, Michael G, Dhar, T. G. Murali, Xiao, Hai-Yun, Gilmore, John L, Marcoux, David, McIntyre, Kim W, Taylor, Tracy L, Shi, Hong, Levesque, Paul C, Marino, Anthony M, Cornelius, Georgia, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Lehman-McKeeman, Lois D, Sun, Huadong, Xie, Jenny H, Carter, Percy H, Dyckman, Alaric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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