IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

Cytokine release syndrome (CRS) is a life-threatening complication induced by systemic inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell therapy. There are currently no immunotherapies with proven clinical efficacy and understanding of the molecular mechan...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-09, Vol.117 (36), p.22351-22356
Hauptverfasser:	Kang, Sujin, Tanaka, Toshio, Inoue, Hitomi, Ono, Chikako, Hashimoto, Shoji, Kioi, Yoshiyuki, Matsumoto, Hisatake, Matsuura, Hiroshi, Matsubara, Tsunehiro, Shimizu, Kentaro, Ogura, Hiroshi, Matsuura, Yoshiharu, Kishimoto, Tadamitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Humanized - therapeutic use Antigens Bacteria Bacterial diseases Bacterial infections Betacoronavirus Biological Sciences Burns - metabolism Burns - pathology Cell activation Cell therapy Cells, Cultured Chimeric antigen receptors Circuits Coagulation Coronavirus Infections - drug therapy Coronavirus Infections - metabolism Coronavirus Infections - pathology Coronaviruses COVID-19 Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - metabolism Cytokine Release Syndrome - pathology Cytokines Cytokines - blood Cytokines - metabolism Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Female Humans Immunotherapy Infections Inflammation Inhibitors Interleukin 10 Interleukin 6 Interleukin 8 Interleukin-6 - blood Interleukin-6 - metabolism Lymphocytes Lymphocytes T Male Middle Aged Molecular modelling Monoclonal antibodies Monocyte chemoattractant protein 1 Monocytes Pandemics Pathogenesis Patients Plasminogen Activator Inhibitor 1 - blood Plasminogen Activator Inhibitor 1 - metabolism Plasminogen activator inhibitors Pneumonia, Viral - drug therapy Pneumonia, Viral - metabolism Pneumonia, Viral - pathology Receptors, Interleukin-6 - antagonists & inhibitors Receptors, Interleukin-6 - metabolism Respiratory distress syndrome Respiratory Distress Syndrome - metabolism Respiratory Distress Syndrome - pathology SARS-CoV-2 Sepsis Sepsis - metabolism Sepsis - pathology Signal Transduction Signaling Viral diseases
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