Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis

Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and disease progression. The aim of this study was to determine the effect of oleuropein on Cx43...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-08, Vol.12 (16), p.15882-15905
Hauptverfasser:	Varela-Eirín, Marta, Carpintero-Fernández, Paula, Sánchez-Temprano, Agustín, Varela-Vázquez, Adrián, Paíno, Carlos Luis, Casado-Díaz, Antonio, Continente, Alfonso Calañas, Mato, Virginia, Fonseca, Eduardo, Kandouz, Mustapha, Blanco, Alfonso, Caeiro, José Ramón, Mayán, María D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antirheumatic Agents - isolation & purification Antirheumatic Agents - pharmacology Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Differentiation - drug effects Cell Line Cellular Microenvironment Cellular Senescence - drug effects Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Chondrogenesis - drug effects Collagen Type II - metabolism Connexin 43 - genetics Connexin 43 - metabolism Female Fruit Humans Iridoids - isolation & purification Iridoids - pharmacology Male NF-kappa B - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Olea - chemistry Osteoarthritis - drug therapy Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology Osteogenesis - drug effects Polyphenols - isolation & purification Polyphenols - pharmacology Priority Research Paper Regeneration - drug effects Signal Transduction Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism
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