Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial

A chemopreventive effect of aspirin (ASA) on lung cancer risk is supported by epidemiologic and preclinical studies. We conducted a randomized, double-blinded study in current heavy smokers to compare modulating effects of intermittent versus continuous low-dose ASA on nasal epithelium gene expressi...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2019-11, Vol.12 (11), p.809-820
Hauptverfasser:	Garland, Linda L, Guillen-Rodriguez, José, Hsu, Chiu-Hsieh, Yozwiak, Michael, Zhang, Hao Helen, Alberts, David S, Davis, Lisa E, Szabo, Eva, Merenstein, Carter, Lel, Julian, Zhang, Xiaohui, Liu, Hanqiao, Liu, Gang, Spira, Avrum E, Beane, Jennifer E, Wojtowicz, Malgorzata, Chow, H-H Sherry
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin - pharmacology Biomarkers - analysis Dose-Response Relationship, Drug Double-Blind Method Female Follow-Up Studies Gene Expression Profiling Gene Expression Regulation - drug effects Humans Inflammation - drug therapy Inflammation - epidemiology Inflammation - genetics Male Middle Aged Nasal Mucosa - drug effects Nasal Mucosa - metabolism Prognosis Smokers - statistics & numerical data Smoking - drug therapy Smoking - epidemiology Smoking - genetics
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