Para‐limbic Structural Abnormalities Are Associated With Internalizing Symptoms in Children With Prenatal Alcohol Exposure
Background Prenatal alcohol exposure (PAE) is associated with a variety of structural abnormalities in the brain, including several within the para‐limbic system. Children with PAE have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying limb...
Gespeichert in:
| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2020-08, Vol.44 (8), p.1598-1608 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1608 |
|---|---|
| container_issue | 8 |
| container_start_page | 1598 |
| container_title | Alcoholism, clinical and experimental research |
| container_volume | 44 |
| creator | Krueger, Alyssa M. Roediger, Donovan J. Mueller, Bryon A. Boys, Christopher A. Hendrickson, Timothy J. Schumacher, Mariah J. Mattson, Sarah N. Jones, Kenneth L. Riley, Edward P. Lim, Kelvin O. Wozniak, Jeffrey R. |
| description | Background
Prenatal alcohol exposure (PAE) is associated with a variety of structural abnormalities in the brain, including several within the para‐limbic system. Children with PAE have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying limbic system anomalies.
Methods
Children aged 8 to 16 with PAE (n = 41) or without PAE (n = 36) underwent an magnetic resonance imaging of the brain and parents completed behavioral questionnaires about their children. Semi‐automated procedures (FreeSurfer) were used to derive para‐limbic volumes from T1‐weighted anatomical images.
Results
There were significant group differences (PAE vs. nonexposed controls) in the caudate, hippocampus, and the putamen; children with PAE had smaller volumes in these regions even after controlling for total intracranial volume. A trend‐level association was seen between caudate volume and internalizing symptoms in children with PAE; smaller caudate volumes (presumably reflecting less optimal neurodevelopment) were associated with higher levels of anxiety and depression symptoms in these children.
Conclusions
Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms in those affected by PAE.
Children with prenatal alcohol exposure (PAE) have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying para‐limbic system anomalies. This study revealed that smaller caudate volumes were associated with higher levels of anxiety and depression symptoms in children with PAE. Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms. |
| doi_str_mv | 10.1111/acer.14390 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7484415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2436268351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4480-3c75e8d57df16ba81ab6585d1278027e745feef95dde380161db2f67b9bdf0873</originalsourceid><addsrcrecordid>eNp9kUFrFDEYhoModrt68QdIwJswNZlJMtmLMCxrWyhYrOIxZJJvuikzkzXJqCse_An9jf4Ss04tejGXBPLw5HvzIvSMkhOa1yttIJxQVq3IA7SgvCIFKev6IVoQynghCJFH6DjGG0IIk0I8RkdVyUsmqFig75c66J8_bns3tM7gqxQmk6age9y0ow-D7l1yEHETADcxeuN0Aos_urTF52OCMGbimxuv8dV-2CU_ROxGvN663gYYZ-4yn3Q6KHvjt77Hm687H6cAT9CjTvcRnt7tS_Thzeb9-qy4eHt6vm4uCsOYJEVlag7S8tp2VLRaUt0KLrmlZS1zUqgZ7wC6FbcWKkmooLYtO1G3q9Z2RNbVEr2evbupHcAaGFNOqHbBDTrslddO_Xszuq269p9VzSRj-UeX6MWdIPhPE8Skbvx0iB5VySpRCllxmqmXM2WCjzFAd_8CJerQlDo0pX43leHnf890j_6pJgN0Br64Hvb_UalmvXk3S38BpuiiUA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2436268351</pqid></control><display><type>article</type><title>Para‐limbic Structural Abnormalities Are Associated With Internalizing Symptoms in Children With Prenatal Alcohol Exposure</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Krueger, Alyssa M. ; Roediger, Donovan J. ; Mueller, Bryon A. ; Boys, Christopher A. ; Hendrickson, Timothy J. ; Schumacher, Mariah J. ; Mattson, Sarah N. ; Jones, Kenneth L. ; Riley, Edward P. ; Lim, Kelvin O. ; Wozniak, Jeffrey R.</creator><creatorcontrib>Krueger, Alyssa M. ; Roediger, Donovan J. ; Mueller, Bryon A. ; Boys, Christopher A. ; Hendrickson, Timothy J. ; Schumacher, Mariah J. ; Mattson, Sarah N. ; Jones, Kenneth L. ; Riley, Edward P. ; Lim, Kelvin O. ; Wozniak, Jeffrey R.</creatorcontrib><description>Background
Prenatal alcohol exposure (PAE) is associated with a variety of structural abnormalities in the brain, including several within the para‐limbic system. Children with PAE have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying limbic system anomalies.
Methods
Children aged 8 to 16 with PAE (n = 41) or without PAE (n = 36) underwent an magnetic resonance imaging of the brain and parents completed behavioral questionnaires about their children. Semi‐automated procedures (FreeSurfer) were used to derive para‐limbic volumes from T1‐weighted anatomical images.
Results
There were significant group differences (PAE vs. nonexposed controls) in the caudate, hippocampus, and the putamen; children with PAE had smaller volumes in these regions even after controlling for total intracranial volume. A trend‐level association was seen between caudate volume and internalizing symptoms in children with PAE; smaller caudate volumes (presumably reflecting less optimal neurodevelopment) were associated with higher levels of anxiety and depression symptoms in these children.
Conclusions
Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms in those affected by PAE.
Children with prenatal alcohol exposure (PAE) have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying para‐limbic system anomalies. This study revealed that smaller caudate volumes were associated with higher levels of anxiety and depression symptoms in children with PAE. Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/acer.14390</identifier><identifier>PMID: 32524616</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Alcohol use ; Anxiety ; Anxiety - diagnostic imaging ; Anxiety - psychology ; Brain ; Caudate Nucleus - diagnostic imaging ; Caudate Nucleus - pathology ; Central Nervous System Depressants - adverse effects ; Child ; Child & adolescent psychiatry ; Children ; Depression ; Depression - diagnostic imaging ; Depression - psychology ; Developmental disabilities ; Ethanol - adverse effects ; Female ; Fetal Alcohol Spectrum Disorder ; Fetal alcohol syndrome ; Hippocampus - diagnostic imaging ; Hippocampus - pathology ; Humans ; Limbic system ; Limbic System - diagnostic imaging ; Limbic System - pathology ; Magnetic Resonance Imaging ; Male ; Mental depression ; Neuroimaging ; Organ Size ; Pregnancy ; Prenatal development ; Prenatal experience ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - diagnostic imaging ; Prenatal Exposure Delayed Effects - psychology ; Putamen ; Putamen - diagnostic imaging ; Putamen - pathology</subject><ispartof>Alcoholism, clinical and experimental research, 2020-08, Vol.44 (8), p.1598-1608</ispartof><rights>2020 Research Society on Alcoholism</rights><rights>2020 Research Society on Alcoholism.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4480-3c75e8d57df16ba81ab6585d1278027e745feef95dde380161db2f67b9bdf0873</citedby><cites>FETCH-LOGICAL-c4480-3c75e8d57df16ba81ab6585d1278027e745feef95dde380161db2f67b9bdf0873</cites><orcidid>0000-0001-8499-9605 ; 0000-0002-3595-087X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facer.14390$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facer.14390$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32524616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krueger, Alyssa M.</creatorcontrib><creatorcontrib>Roediger, Donovan J.</creatorcontrib><creatorcontrib>Mueller, Bryon A.</creatorcontrib><creatorcontrib>Boys, Christopher A.</creatorcontrib><creatorcontrib>Hendrickson, Timothy J.</creatorcontrib><creatorcontrib>Schumacher, Mariah J.</creatorcontrib><creatorcontrib>Mattson, Sarah N.</creatorcontrib><creatorcontrib>Jones, Kenneth L.</creatorcontrib><creatorcontrib>Riley, Edward P.</creatorcontrib><creatorcontrib>Lim, Kelvin O.</creatorcontrib><creatorcontrib>Wozniak, Jeffrey R.</creatorcontrib><title>Para‐limbic Structural Abnormalities Are Associated With Internalizing Symptoms in Children With Prenatal Alcohol Exposure</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background
Prenatal alcohol exposure (PAE) is associated with a variety of structural abnormalities in the brain, including several within the para‐limbic system. Children with PAE have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying limbic system anomalies.
Methods
Children aged 8 to 16 with PAE (n = 41) or without PAE (n = 36) underwent an magnetic resonance imaging of the brain and parents completed behavioral questionnaires about their children. Semi‐automated procedures (FreeSurfer) were used to derive para‐limbic volumes from T1‐weighted anatomical images.
Results
There were significant group differences (PAE vs. nonexposed controls) in the caudate, hippocampus, and the putamen; children with PAE had smaller volumes in these regions even after controlling for total intracranial volume. A trend‐level association was seen between caudate volume and internalizing symptoms in children with PAE; smaller caudate volumes (presumably reflecting less optimal neurodevelopment) were associated with higher levels of anxiety and depression symptoms in these children.
Conclusions
Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms in those affected by PAE.
Children with prenatal alcohol exposure (PAE) have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying para‐limbic system anomalies. This study revealed that smaller caudate volumes were associated with higher levels of anxiety and depression symptoms in children with PAE. Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms.</description><subject>Adolescent</subject><subject>Alcohol use</subject><subject>Anxiety</subject><subject>Anxiety - diagnostic imaging</subject><subject>Anxiety - psychology</subject><subject>Brain</subject><subject>Caudate Nucleus - diagnostic imaging</subject><subject>Caudate Nucleus - pathology</subject><subject>Central Nervous System Depressants - adverse effects</subject><subject>Child</subject><subject>Child & adolescent psychiatry</subject><subject>Children</subject><subject>Depression</subject><subject>Depression - diagnostic imaging</subject><subject>Depression - psychology</subject><subject>Developmental disabilities</subject><subject>Ethanol - adverse effects</subject><subject>Female</subject><subject>Fetal Alcohol Spectrum Disorder</subject><subject>Fetal alcohol syndrome</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Limbic system</subject><subject>Limbic System - diagnostic imaging</subject><subject>Limbic System - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mental depression</subject><subject>Neuroimaging</subject><subject>Organ Size</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - diagnostic imaging</subject><subject>Prenatal Exposure Delayed Effects - psychology</subject><subject>Putamen</subject><subject>Putamen - diagnostic imaging</subject><subject>Putamen - pathology</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFrFDEYhoModrt68QdIwJswNZlJMtmLMCxrWyhYrOIxZJJvuikzkzXJqCse_An9jf4Ss04tejGXBPLw5HvzIvSMkhOa1yttIJxQVq3IA7SgvCIFKev6IVoQynghCJFH6DjGG0IIk0I8RkdVyUsmqFig75c66J8_bns3tM7gqxQmk6age9y0ow-D7l1yEHETADcxeuN0Aos_urTF52OCMGbimxuv8dV-2CU_ROxGvN663gYYZ-4yn3Q6KHvjt77Hm687H6cAT9CjTvcRnt7tS_Thzeb9-qy4eHt6vm4uCsOYJEVlag7S8tp2VLRaUt0KLrmlZS1zUqgZ7wC6FbcWKkmooLYtO1G3q9Z2RNbVEr2evbupHcAaGFNOqHbBDTrslddO_Xszuq269p9VzSRj-UeX6MWdIPhPE8Skbvx0iB5VySpRCllxmqmXM2WCjzFAd_8CJerQlDo0pX43leHnf890j_6pJgN0Br64Hvb_UalmvXk3S38BpuiiUA</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Krueger, Alyssa M.</creator><creator>Roediger, Donovan J.</creator><creator>Mueller, Bryon A.</creator><creator>Boys, Christopher A.</creator><creator>Hendrickson, Timothy J.</creator><creator>Schumacher, Mariah J.</creator><creator>Mattson, Sarah N.</creator><creator>Jones, Kenneth L.</creator><creator>Riley, Edward P.</creator><creator>Lim, Kelvin O.</creator><creator>Wozniak, Jeffrey R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K7.</scope><scope>K9.</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8499-9605</orcidid><orcidid>https://orcid.org/0000-0002-3595-087X</orcidid></search><sort><creationdate>202008</creationdate><title>Para‐limbic Structural Abnormalities Are Associated With Internalizing Symptoms in Children With Prenatal Alcohol Exposure</title><author>Krueger, Alyssa M. ; Roediger, Donovan J. ; Mueller, Bryon A. ; Boys, Christopher A. ; Hendrickson, Timothy J. ; Schumacher, Mariah J. ; Mattson, Sarah N. ; Jones, Kenneth L. ; Riley, Edward P. ; Lim, Kelvin O. ; Wozniak, Jeffrey R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4480-3c75e8d57df16ba81ab6585d1278027e745feef95dde380161db2f67b9bdf0873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Alcohol use</topic><topic>Anxiety</topic><topic>Anxiety - diagnostic imaging</topic><topic>Anxiety - psychology</topic><topic>Brain</topic><topic>Caudate Nucleus - diagnostic imaging</topic><topic>Caudate Nucleus - pathology</topic><topic>Central Nervous System Depressants - adverse effects</topic><topic>Child</topic><topic>Child & adolescent psychiatry</topic><topic>Children</topic><topic>Depression</topic><topic>Depression - diagnostic imaging</topic><topic>Depression - psychology</topic><topic>Developmental disabilities</topic><topic>Ethanol - adverse effects</topic><topic>Female</topic><topic>Fetal Alcohol Spectrum Disorder</topic><topic>Fetal alcohol syndrome</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Limbic system</topic><topic>Limbic System - diagnostic imaging</topic><topic>Limbic System - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mental depression</topic><topic>Neuroimaging</topic><topic>Organ Size</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Prenatal experience</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - diagnostic imaging</topic><topic>Prenatal Exposure Delayed Effects - psychology</topic><topic>Putamen</topic><topic>Putamen - diagnostic imaging</topic><topic>Putamen - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krueger, Alyssa M.</creatorcontrib><creatorcontrib>Roediger, Donovan J.</creatorcontrib><creatorcontrib>Mueller, Bryon A.</creatorcontrib><creatorcontrib>Boys, Christopher A.</creatorcontrib><creatorcontrib>Hendrickson, Timothy J.</creatorcontrib><creatorcontrib>Schumacher, Mariah J.</creatorcontrib><creatorcontrib>Mattson, Sarah N.</creatorcontrib><creatorcontrib>Jones, Kenneth L.</creatorcontrib><creatorcontrib>Riley, Edward P.</creatorcontrib><creatorcontrib>Lim, Kelvin O.</creatorcontrib><creatorcontrib>Wozniak, Jeffrey R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krueger, Alyssa M.</au><au>Roediger, Donovan J.</au><au>Mueller, Bryon A.</au><au>Boys, Christopher A.</au><au>Hendrickson, Timothy J.</au><au>Schumacher, Mariah J.</au><au>Mattson, Sarah N.</au><au>Jones, Kenneth L.</au><au>Riley, Edward P.</au><au>Lim, Kelvin O.</au><au>Wozniak, Jeffrey R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Para‐limbic Structural Abnormalities Are Associated With Internalizing Symptoms in Children With Prenatal Alcohol Exposure</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2020-08</date><risdate>2020</risdate><volume>44</volume><issue>8</issue><spage>1598</spage><epage>1608</epage><pages>1598-1608</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><abstract>Background
Prenatal alcohol exposure (PAE) is associated with a variety of structural abnormalities in the brain, including several within the para‐limbic system. Children with PAE have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying limbic system anomalies.
Methods
Children aged 8 to 16 with PAE (n = 41) or without PAE (n = 36) underwent an magnetic resonance imaging of the brain and parents completed behavioral questionnaires about their children. Semi‐automated procedures (FreeSurfer) were used to derive para‐limbic volumes from T1‐weighted anatomical images.
Results
There were significant group differences (PAE vs. nonexposed controls) in the caudate, hippocampus, and the putamen; children with PAE had smaller volumes in these regions even after controlling for total intracranial volume. A trend‐level association was seen between caudate volume and internalizing symptoms in children with PAE; smaller caudate volumes (presumably reflecting less optimal neurodevelopment) were associated with higher levels of anxiety and depression symptoms in these children.
Conclusions
Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms in those affected by PAE.
Children with prenatal alcohol exposure (PAE) have higher rates of internalizing disorders, including depression and anxiety, which may be related to underlying para‐limbic system anomalies. This study revealed that smaller caudate volumes were associated with higher levels of anxiety and depression symptoms in children with PAE. Caudate structure may be disproportionately affected by PAE and may be associated with the later development of internalizing symptoms.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32524616</pmid><doi>10.1111/acer.14390</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8499-9605</orcidid><orcidid>https://orcid.org/0000-0002-3595-087X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0145-6008 |
| ispartof | Alcoholism, clinical and experimental research, 2020-08, Vol.44 (8), p.1598-1608 |
| issn | 0145-6008 1530-0277 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7484415 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Alcohol use Anxiety Anxiety - diagnostic imaging Anxiety - psychology Brain Caudate Nucleus - diagnostic imaging Caudate Nucleus - pathology Central Nervous System Depressants - adverse effects Child Child & adolescent psychiatry Children Depression Depression - diagnostic imaging Depression - psychology Developmental disabilities Ethanol - adverse effects Female Fetal Alcohol Spectrum Disorder Fetal alcohol syndrome Hippocampus - diagnostic imaging Hippocampus - pathology Humans Limbic system Limbic System - diagnostic imaging Limbic System - pathology Magnetic Resonance Imaging Male Mental depression Neuroimaging Organ Size Pregnancy Prenatal development Prenatal experience Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - diagnostic imaging Prenatal Exposure Delayed Effects - psychology Putamen Putamen - diagnostic imaging Putamen - pathology |
| title | Para‐limbic Structural Abnormalities Are Associated With Internalizing Symptoms in Children With Prenatal Alcohol Exposure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T05%3A20%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Para%E2%80%90limbic%20Structural%20Abnormalities%20Are%20Associated%20With%20Internalizing%20Symptoms%20in%20Children%20With%20Prenatal%20Alcohol%20Exposure&rft.jtitle=Alcoholism,%20clinical%20and%20experimental%20research&rft.au=Krueger,%20Alyssa%20M.&rft.date=2020-08&rft.volume=44&rft.issue=8&rft.spage=1598&rft.epage=1608&rft.pages=1598-1608&rft.issn=0145-6008&rft.eissn=1530-0277&rft_id=info:doi/10.1111/acer.14390&rft_dat=%3Cproquest_pubme%3E2436268351%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2436268351&rft_id=info:pmid/32524616&rfr_iscdi=true |