Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

Our understanding of dynamic interactions between airway basal stem cells (ABSCs) and their signaling niches in homeostasis, injury, and aging remains elusive. Using transgenic mice and pharmacologic studies, we found that Wnt/β-catenin within ABSCs was essential for proliferation post-injury in viv...

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Veröffentlicht in:	Cell stem cell 2020-09, Vol.27 (3), p.413-429.e4
Hauptverfasser:	Aros, Cody J., Vijayaraj, Preethi, Pantoja, Carla J., Bisht, Bharti, Meneses, Luisa K., Sandlin, Jenna M., Tse, Jonathan A., Chen, Michelle W., Purkayastha, Arunima, Shia, David W., Sucre, Jennifer M.S., Rickabaugh, Tammy M., Vladar, Eszter K., Paul, Manash K., Gomperts, Brigitte N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals beta Catenin - metabolism beta-catenin Cell Differentiation Cell Proliferation homeostasis intercartilaginous zone lung repair Mice Mice, Transgenic niche signaling pathway Stem Cells - metabolism Wnt Wnt Signaling Pathway
Online-Zugang:	Volltext
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