Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis

Previously, we have shown that Staphylococcus (S) aureus induces a glycolytic response in retinal residential (microglia) and infiltrated cells (neutrophils and macrophages) during endophthalmitis. In this study, we sought to investigate the physiological role of glycolysis in bacterial endophthalmi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental eye research 2020-08, Vol.197, p.108079-108079, Article 108079
Hauptverfasser:	Francis, Rebecca, Singh, Pawan Kumar, Singh, Sukhvinder, Giri, Shailendra, Kumar, Ashok
Format:	Artikel
Sprache:	eng
Schlagworte:	2DG Animals Antimetabolites - pharmacology Blotting, Western Deoxyglucose - pharmacology Disease Models, Animal Endophthalmitis Endophthalmitis - drug therapy Endophthalmitis - immunology Endophthalmitis - pathology Enzyme-Linked Immunosorbent Assay Eye Infections, Bacterial - drug therapy Eye Infections, Bacterial - immunology Eye Infections, Bacterial - pathology Female Glycolysis Glycolysis - drug effects Immunity, Innate - drug effects Inflammation Male Mice Mice, Inbred C57BL Retina S. aureus Staphylococcal Infections - drug therapy Staphylococcal Infections - immunology Staphylococcal Infections - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!