Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation
Summary Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive disease (VOD), remains a multi‐organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi‐organ dysfunction, overall mortality rates remain >80%. Howe...
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| Veröffentlicht in: | British journal of haematology 2020-09, Vol.190 (6), p.822-836 |
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| container_title | British journal of haematology |
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| creator | Cairo, Mitchell S. Cooke, Kenneth R. Lazarus, Hillard M. Chao, Nelson |
| description | Summary
Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive disease (VOD), remains a multi‐organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi‐organ dysfunction, overall mortality rates remain >80%. However, the definitions related to the diagnosis and grading of SOS/VOD after HCT are almost 25 years old and require new and contemporary modifications. Importantly, the pathophysiology of SOS/VOD, including the contribution of dysregulated inflammatory and coagulation cascades as well as the critical importance of liver and vascular derived endothelial dysfunction, have been elucidated. Here we summarise new information on pathogenesis of SOS/VOD; identify modifiable and unmodifiable risk factors for disease development; propose novel, contemporary and panel opinion‐based diagnostic criteria and an innovative organ‐based method of SOS/VOD grading classification; and review current approaches for prophylaxis and treatment of SOS/VOD. This review will hopefully illuminate pathways responsible for drug‐induced liver injury and manifestations of disease, sharpen awareness of risk for disease development and enhance the timely and correct diagnosis of SOS/VOD post‐HCT. |
| doi_str_mv | 10.1111/bjh.16557 |
| format | Article |
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Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive disease (VOD), remains a multi‐organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi‐organ dysfunction, overall mortality rates remain >80%. However, the definitions related to the diagnosis and grading of SOS/VOD after HCT are almost 25 years old and require new and contemporary modifications. Importantly, the pathophysiology of SOS/VOD, including the contribution of dysregulated inflammatory and coagulation cascades as well as the critical importance of liver and vascular derived endothelial dysfunction, have been elucidated. Here we summarise new information on pathogenesis of SOS/VOD; identify modifiable and unmodifiable risk factors for disease development; propose novel, contemporary and panel opinion‐based diagnostic criteria and an innovative organ‐based method of SOS/VOD grading classification; and review current approaches for prophylaxis and treatment of SOS/VOD. This review will hopefully illuminate pathways responsible for drug‐induced liver injury and manifestations of disease, sharpen awareness of risk for disease development and enhance the timely and correct diagnosis of SOS/VOD post‐HCT.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.16557</identifier><identifier>PMID: 32133623</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Blood Coagulation ; definitions ; Diagnosis ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; grading ; haematopoietic cell transplantation ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hepatic Veno-Occlusive Disease - classification ; Hepatic Veno-Occlusive Disease - diagnosis ; Hepatic Veno-Occlusive Disease - etiology ; Humans ; Inflammation ; Inflammation - blood ; Inflammation - classification ; Inflammation - diagnosis ; Inflammation - etiology ; Liver diseases ; Pathogenesis ; Pathophysiology ; Prophylaxis ; Risk Factors ; sinusoidal obstruction syndrome ; Transplantation ; veno‐occlusive disease</subject><ispartof>British journal of haematology, 2020-09, Vol.190 (6), p.822-836</ispartof><rights>2020 British Society for Haematology and John Wiley & Sons Ltd</rights><rights>2020 British Society for Haematology and John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5097-576026408dad752c3a1ccbdc26c939912613646ea3f36ecca5c7188e62d899e73</citedby><cites>FETCH-LOGICAL-c5097-576026408dad752c3a1ccbdc26c939912613646ea3f36ecca5c7188e62d899e73</cites><orcidid>0000-0002-2075-434X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.16557$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.16557$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32133623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cairo, Mitchell S.</creatorcontrib><creatorcontrib>Cooke, Kenneth R.</creatorcontrib><creatorcontrib>Lazarus, Hillard M.</creatorcontrib><creatorcontrib>Chao, Nelson</creatorcontrib><title>Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive disease (VOD), remains a multi‐organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi‐organ dysfunction, overall mortality rates remain >80%. However, the definitions related to the diagnosis and grading of SOS/VOD after HCT are almost 25 years old and require new and contemporary modifications. Importantly, the pathophysiology of SOS/VOD, including the contribution of dysregulated inflammatory and coagulation cascades as well as the critical importance of liver and vascular derived endothelial dysfunction, have been elucidated. Here we summarise new information on pathogenesis of SOS/VOD; identify modifiable and unmodifiable risk factors for disease development; propose novel, contemporary and panel opinion‐based diagnostic criteria and an innovative organ‐based method of SOS/VOD grading classification; and review current approaches for prophylaxis and treatment of SOS/VOD. This review will hopefully illuminate pathways responsible for drug‐induced liver injury and manifestations of disease, sharpen awareness of risk for disease development and enhance the timely and correct diagnosis of SOS/VOD post‐HCT.</description><subject>Blood Coagulation</subject><subject>definitions</subject><subject>Diagnosis</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>grading</subject><subject>haematopoietic cell transplantation</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hepatic Veno-Occlusive Disease - classification</subject><subject>Hepatic Veno-Occlusive Disease - diagnosis</subject><subject>Hepatic Veno-Occlusive Disease - etiology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - classification</subject><subject>Inflammation - diagnosis</subject><subject>Inflammation - etiology</subject><subject>Liver diseases</subject><subject>Pathogenesis</subject><subject>Pathophysiology</subject><subject>Prophylaxis</subject><subject>Risk Factors</subject><subject>sinusoidal obstruction syndrome</subject><subject>Transplantation</subject><subject>veno‐occlusive disease</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAYRS0EosPAghdAlthQiXT8kzjJphKUn4KKZlFga31jO4lHHjvESau8CM-LZ6ZUgIQ3luyj8137IvSckjOa1mqz7c6oKIryAVpQLoqM0Zw-RAtCSJlRklcn6EmMW0IoJwV9jE44o5wLxhfo55egbWONxtpC60McrcJqsKMZLLzG7QDa-hYrBzEmTsFog8fgNfbm1s3YuElZDWMS9DB2oe_maIML7YxDgzuTDpPwen29-r5-h6FJXtyB2cEY-mDNYZpxDo8D-Ng78ONhwlP0qAEXzbO7fYm-fXj_9eIyu1p__HTx5ipTBanLrCgFYSInlQZdFkxxoEpttGJC1byuKRPpO3JhgDdcGKWgUCWtKiOYruralHyJzo_eftrsjFbGpyBO9oPdwTDLAFb-feNtJ9twI8u84nXFk-DVnWAIPyYTR7mzcf8i8CZMUTKeBop8H2SJXv6DbsM0-PQ8yfKc8aLihCXq9EipIcQ4mOY-DCVy37ZMbctD24l98Wf6e_J3vQlYHYFb68z8f5N8-_nyqPwF6ly3aw</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Cairo, Mitchell S.</creator><creator>Cooke, Kenneth R.</creator><creator>Lazarus, Hillard M.</creator><creator>Chao, Nelson</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2075-434X</orcidid></search><sort><creationdate>202009</creationdate><title>Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation</title><author>Cairo, Mitchell S. ; Cooke, Kenneth R. ; Lazarus, Hillard M. ; Chao, Nelson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5097-576026408dad752c3a1ccbdc26c939912613646ea3f36ecca5c7188e62d899e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blood Coagulation</topic><topic>definitions</topic><topic>Diagnosis</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - pathology</topic><topic>grading</topic><topic>haematopoietic cell transplantation</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hepatic Veno-Occlusive Disease - classification</topic><topic>Hepatic Veno-Occlusive Disease - diagnosis</topic><topic>Hepatic Veno-Occlusive Disease - etiology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - classification</topic><topic>Inflammation - diagnosis</topic><topic>Inflammation - etiology</topic><topic>Liver diseases</topic><topic>Pathogenesis</topic><topic>Pathophysiology</topic><topic>Prophylaxis</topic><topic>Risk Factors</topic><topic>sinusoidal obstruction syndrome</topic><topic>Transplantation</topic><topic>veno‐occlusive disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cairo, Mitchell S.</creatorcontrib><creatorcontrib>Cooke, Kenneth R.</creatorcontrib><creatorcontrib>Lazarus, Hillard M.</creatorcontrib><creatorcontrib>Chao, Nelson</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cairo, Mitchell S.</au><au>Cooke, Kenneth R.</au><au>Lazarus, Hillard M.</au><au>Chao, Nelson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2020-09</date><risdate>2020</risdate><volume>190</volume><issue>6</issue><spage>822</spage><epage>836</epage><pages>822-836</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Summary
Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive disease (VOD), remains a multi‐organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi‐organ dysfunction, overall mortality rates remain >80%. However, the definitions related to the diagnosis and grading of SOS/VOD after HCT are almost 25 years old and require new and contemporary modifications. Importantly, the pathophysiology of SOS/VOD, including the contribution of dysregulated inflammatory and coagulation cascades as well as the critical importance of liver and vascular derived endothelial dysfunction, have been elucidated. Here we summarise new information on pathogenesis of SOS/VOD; identify modifiable and unmodifiable risk factors for disease development; propose novel, contemporary and panel opinion‐based diagnostic criteria and an innovative organ‐based method of SOS/VOD grading classification; and review current approaches for prophylaxis and treatment of SOS/VOD. This review will hopefully illuminate pathways responsible for drug‐induced liver injury and manifestations of disease, sharpen awareness of risk for disease development and enhance the timely and correct diagnosis of SOS/VOD post‐HCT.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>32133623</pmid><doi>10.1111/bjh.16557</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-2075-434X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood Coagulation definitions Diagnosis Endothelium, Vascular - metabolism Endothelium, Vascular - pathology grading haematopoietic cell transplantation Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hepatic Veno-Occlusive Disease - classification Hepatic Veno-Occlusive Disease - diagnosis Hepatic Veno-Occlusive Disease - etiology Humans Inflammation Inflammation - blood Inflammation - classification Inflammation - diagnosis Inflammation - etiology Liver diseases Pathogenesis Pathophysiology Prophylaxis Risk Factors sinusoidal obstruction syndrome Transplantation veno‐occlusive disease |
| title | Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation |
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