Estimation of treatment effects and model diagnostics with two-way time-varying treatment switching: an application to a head and neck study

Treatment switching frequently occurs in clinical trials due to ethical reasons. Intent-to-treat analysis without adjusting for switching yields biased and inefficient estimates of the treatment effects. In this paper, we propose a class of semiparametric semi-competing risks transition survival mod...

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Veröffentlicht in:Lifetime data analysis 2020-10, Vol.26 (4), p.685-707
Hauptverfasser: Chen, Qingxia, Zhang, Fan, Chen, Ming-Hui, Cong, Xiuyu Julie
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Sprache:eng
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