Anti-PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells

Anti-programmed cell death protein 1 (PD-1) therapy has demonstrated inconsistent therapeutic results in patients with glioblastoma (GBM) including those with profound impairments in CD8 T-cell effector responses. We ablated the gene in BL6 mice and intercrossed them with Ntv-a mice to determine how...

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Veröffentlicht in:	Clinical cancer research 2020-09, Vol.26 (17), p.4699-4712
Hauptverfasser:	Rao, Ganesh, Latha, Khatri, Ott, Martina, Sabbagh, Aria, Marisetty, Anantha, Ling, Xiaoyang, Zamler, Daniel, Doucette, Tiffany A, Yang, Yuhui, Kong, Ling-Yuan, Wei, Jun, Fuller, Gregory N, Benavides, Fernando, Sonabend, Adam M, Long, James, Li, Shulin, Curran, Michael, Heimberger, Amy B
Format:	Artikel
Sprache:	eng
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