Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia

Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although several studies have demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), its mechanisms in cerebellar ataxia remain largely unknown. Here, we investigated the neuroprotective effects of H.E. t...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.14945, Article 14945
Hauptverfasser:	Chong, Pit Shan, Khairuddin, Sharafuddin, Tse, Anna Chung Kwan, Hiew, Lih Fhung, Lau, Chun Lok, Tipoe, George Lim, Fung, Man-Lung, Wong, Kah Hui, Lim, Lee Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 631/378/1689 631/378/1689/364 692/308/575 Animal models Animals Antisense RNA Behavior, Animal - drug effects Breast cancer Cerebellar Ataxia - chemically induced Cerebellar Ataxia - drug therapy Cerebellar Ataxia - psychology Chemotherapy Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Disks Large Homolog 4 Protein - genetics Disks Large Homolog 4 Protein - metabolism Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Hericium - chemistry Hericium - growth & development Humanities and Social Sciences Interleukin 6 Male Matrix metalloproteinase Metalloproteinase Motor Disorders - genetics Motor Disorders - metabolism Motor Disorders - pathology Motor Disorders - prevention & control multidisciplinary Neuroplasticity Neuroprotective Agents - pharmacology Neurotoxins - toxicity NF-κB protein Non-coding RNA Peptide nucleic acids pH effects Platinum Purkinje Cells - drug effects Purkinje Cells - pathology Pyridines - toxicity Rats Rats, Sprague-Dawley Science Science (multidisciplinary) Solid tumors Transcription Tumor cell lines Tumors Xenografts
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