Aryl hydrocarbon receptor antagonism before reperfusion attenuates cerebral ischaemia/reperfusion injury in rats

Aryl hydrocarbon receptor (AhR) antagonism can mitigate cellular damage associated with cerebral ischaemia and reperfusion (I/R) injury. This study investigated the neuroprotective effects of AhR antagonist administration before reperfusion in a rat stroke model and influence of the timing of AhR an...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.14906-14906, Article 14906
Hauptverfasser:	Kwon, Jae-Im, Heo, Hwon, Ham, Su Jeong, Chae, Yeon Ji, Lee, Do-Wan, Kim, Sang Tae, Min, Joongkee, Sung, Yu Sub, Kim, Kyung Won, Choi, Yoonseok, Woo, Dong Cheol, Woo, Chul-Woong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689 692/617/375 Animals Apoptosis Brain injury Brain Ischemia - etiology Brain Ischemia - pathology Brain Ischemia - prevention & control Diffusion coefficient Disease Models, Animal DNA nucleotidylexotransferase Edema Humanities and Social Sciences Hydrocarbons Ischemia Labeling Lactams - pharmacology Magnetic resonance imaging Male multidisciplinary Mupirocin - analogs & derivatives Mupirocin - pharmacology Neuroimaging Neuroprotection Neuroprotective Agents - pharmacology Rats Rats, Sprague-Dawley Receptors, Aryl Hydrocarbon - antagonists & inhibitors Reperfusion Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - prevention & control Science Science (multidisciplinary) Stroke
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