Activation of the Toll pathway in Aedes aegypti blocks the development of emerging third-stage larvae of drug-resistant Dirofilaria immitis

•Emergence assay used to study drug-resistant D. immitis development in mosquitoes.•Mosquito Toll signaling blocks eL3 of two drug-resistant D. immitis strains.•Different drug-resistant D. immitis strains are blocked by distinct mechanisms. Dirofilaria immitis is the globally distributed agent of he...

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Veröffentlicht in:	Veterinary parasitology 2020-06, Vol.282, p.109100-109100, Article 109100
Hauptverfasser:	McCrea, Abigail R., Jimenez Castro, Pablo D., Kaplan, Ray M., Povelones, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - immunology Aedes - parasitology Aedes aegypti Animals Dirofilaria immitis Dirofilaria immitis - drug effects Dirofilaria immitis - growth & development Drug Resistance eL3 Emerging third-stage larvae Filaricides - pharmacology Heartworm Host-parasite interactions Innate immunity Insect Proteins - genetics Insect Proteins - immunology Larva - drug effects Larva - growth & development Macrocyclic lactone Mosquito Mosquito Vectors - immunology Mosquito Vectors - parasitology RNA-interference Signal Transduction - drug effects Toll pathway
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