Inhibition of LSD1 in MDS progenitors restores differentiation of CD141Hi conventional dendritic cells

The use of immunotherapy to treat patients with myelodysplastic syndromes (MDS) shows promise but is limited by our incomplete understanding of the immunologic milieu . In solid tumors, CD141 Hi conventional dendritic cells (CD141 Hi cDCs) are necessary for antitumor immunosurveillance and the respo...

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Veröffentlicht in:	Leukemia 2020-09, Vol.34 (9), p.2460-2472
Hauptverfasser:	Srivastava, Pragya, Tzetzo, Stephanie L., Gomez, Eduardo Cortes, Eng, Kevin H., Jani Sait, Sheila N., Kuechle, Joseph B., Singh, Prashant K., De Jong, Kitty, Wiatrowski, Kyle R., Peresie, Jennifer, Dimitroff, Ava, Lynch, Miranda L., Wang, Jianmin, Abrams, Scott I., Griffiths, Elizabeth A., Nemeth, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 38/91 631/136/232/2059 631/67/1990/1673 82/80 Antitumor activity Bone marrow Bone tumors Cancer Research Cell differentiation Critical Care Medicine Dendritic cells Differentiation Epigenetics Hematology Immunosurveillance Immunotherapy Intensive Interferon Interferon regulatory factor Internal Medicine Lysine Medicine Medicine & Public Health Myelodysplastic syndrome Myelodysplastic syndromes Oncology Osteoprogenitor cells Solid tumors Survival Tumors
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