Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4

The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SZ). Despite the debilitating...

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Veröffentlicht in:	Molecular psychiatry 2021-06, Vol.26 (6), p.1967-1979
Hauptverfasser:	Rein, Benjamin, Tan, Tao, Yang, Fengwei, Wang, Wei, Williams, Jamal, Zhang, Freddy, Mills, Alea, Yan, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 38/39 38/77 45/91 631/378 692/699/476/1373 9/74 Autism Behavioral Sciences Biological Psychology Care and treatment Chromosome 16 Cognitive ability Copy number Copy number variations Development and progression Excitability GABA Genetic aspects Genomes Health aspects Hypersensitivity Intellectual disabilities Medicine Medicine & Public Health Mental disorders Molecular modelling Mutation hot spots Neurosciences Neurotransmitters Pervasive developmental disorders Pharmacotherapy Phenotypes Physiological aspects Prefrontal cortex Psychiatry Schizophrenia Sensorimotor gating Synapses Synaptic transmission Transcription Transcription factors γ-Aminobutyric acid
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