Network Pharmacology Analysis and Molecular Characterization of the Herbal Medicine Formulation Qi-Fu-Yin for the Inhibition of the Neuroinflammatory Biomarker iNOS in Microglial BV-2 Cells: Implication for the Treatment of Alzheimer’s Disease

Aberrant microglial activation drives neuroinflammation and neurodegeneration in Alzheimer’s disease (AD). The present study is aimed at investigating whether the herbal formula Qi-Fu-Yin (QFY) could inhibit the inflammatory activation of cultured BV-2 microglia. A network pharmacology approach was...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-15
Hauptverfasser:	Rong, Jianhui, Chen, Hubiao, Zhao, Jia, Chen, Qilei, Wang, Weiwei, Ngo, Fung Yin, Gao, Jin-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - pathology Animals Antibodies Bioassays Biomarkers Biomarkers - metabolism Brain Brain - pathology Cell culture Cell Line Cyclooxygenase 2 - metabolism Dementia Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gene Ontology Ginsenosides - chemistry Ginsenosides - pharmacology Ginsenosides - therapeutic use Herbal Medicine Humans Inflammation - complications Inflammation - drug therapy Ingredients Lipopolysaccharides - pharmacology Mice Microglia - drug effects Microglia - enzymology Nerve Tissue Proteins - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Ontology Penicillin Peptides Proteins Rhizome - chemistry Signal Transduction Software
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