Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro

The recent outbreak of novel coronavirus pneumonia (COVID-19) caused by a new coronavirus has posed a great threat to public health. Identifying safe and effective antivirals is of urgent demand to cure the huge number of patients. Virus-encoded proteases are considered potential drug targets. The h...

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Veröffentlicht in:	Virologica Sinica 2020-12, Vol.35 (6), p.776-784
Hauptverfasser:	Zhang, Leike, Liu, Jia, Cao, Ruiyuan, Xu, Mingyue, Wu, Yan, Shang, Weijuan, Wang, Xi, Zhang, Huanyu, Jiang, Xiaming, Sun, Yuan, Hu, Hengrui, Li, Yufeng, Zou, Gang, Zhang, Min, Zhao, Lei, Li, Wei, Guo, Xiaojia, Zhuang, Xiaomei, Yang, Xing-Lou, Shi, Zheng-Li, Deng, Fei, Hu, Zhihong, Xiao, Gengfu, Wang, Manli, Zhong, Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Biochemistry Biomedical and Life Sciences Biomedicine Cell Line Chlorocebus aethiops Coronaviridae Coronavirus 3C Proteases - antagonists & inhibitors Coronavirus 3C Proteases - chemistry Coronavirus 3C Proteases - metabolism Coronaviruses COVID-19 COVID-19 - blood COVID-19 - drug therapy COVID-19 - virology Drug Combinations HIV Human immunodeficiency virus Humans Lopinavir Lopinavir - blood Lopinavir - pharmacology Male Medical Microbiology Microbial Genetics and Genomics Microbiology Molecular Docking Simulation Oncology Pharmacokinetics Proteinase inhibitors Public health Research Article Ritonavir Ritonavir - blood Ritonavir - pharmacology SARS-CoV-2 - drug effects SARS-CoV-2 - enzymology Severe acute respiratory syndrome coronavirus 2 Tablets Therapeutic targets Vero Cells Viral Protease Inhibitors - chemistry Viral Protease Inhibitors - pharmacology Virology
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