The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions
Pleural effusion (PE) remains insurmountable challenge and public health problem, requiring novel noninvasive biomarkers for accurate diagnosis. The aim of this study was to assess the clinical significance of apolipoprotein E (Apo-E) in PE, in order to determine its potential use as a diagnostic bi...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-03, Vol.99 (10), p.e19320-e19320 |
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| creator | Xue, Qing Fang, Guiju Deng, Xinyu Zhang, Canhui Liu, Zhixin Peng, Zhiwen Lai, Zibiao Peng, Yunjuan Wu, Jianhui |
| description | Pleural effusion (PE) remains insurmountable challenge and public health problem, requiring novel noninvasive biomarkers for accurate diagnosis. The aim of this study was to assess the clinical significance of apolipoprotein E (Apo-E) in PE, in order to determine its potential use as a diagnostic biomarker for malignant PE (MPE).PE samples were obtained from 127 patients and the etiology of PE was determined by multiple diagnostic techniques. Apo-E levels were then measured in the pleural fluid samples.58 PE patients were diagnosed with tumors, while 69 were tumor-free. Apo-E levels in MPE patients were significantly higher than those with benign PE (BPE) (P |
| doi_str_mv | 10.1097/MD.0000000000019320 |
| format | Article |
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The aim of this study was to assess the clinical significance of apolipoprotein E (Apo-E) in PE, in order to determine its potential use as a diagnostic biomarker for malignant PE (MPE).PE samples were obtained from 127 patients and the etiology of PE was determined by multiple diagnostic techniques. Apo-E levels were then measured in the pleural fluid samples.58 PE patients were diagnosed with tumors, while 69 were tumor-free. Apo-E levels in MPE patients were significantly higher than those with benign PE (BPE) (P < .05). An Apo-E cut-off of 69.96 ng/mL yielded sensitivity and specificity of 79.31% and 73.91% respectively for MPE detection. The area under the curve for Apo-E was 0.793 (95% confidence interval: 0.712 to 0.860), which was smaller than that of carcinoembryonic antigen (CEA) (Z = 2.081, P<.05). In addition, the combination of Apo-E and CEA detection yielded a higher sensitivity of 87.90% and specificity of 95.65% in diagnosing MPE.In conclusion, Apo-E levels in PE may be a potential biomarker for the detection of MPE. The combined detection of Apo-E and CEA could improve the diagnostic sensitivity and specificity for MPE. These findings provide a simple and convenient method for clinical screening and detection of PE.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000019320</identifier><identifier>PMID: 32150067</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Apolipoproteins E - metabolism ; Biomarkers, Tumor - metabolism ; Exudates and Transudates - metabolism ; Female ; Humans ; Male ; Middle Aged ; Observational Study ; Pleural Effusion, Malignant - diagnosis ; Pleural Effusion, Malignant - metabolism ; Sensitivity and Specificity</subject><ispartof>Medicine (Baltimore), 2020-03, Vol.99 (10), p.e19320-e19320</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4503-b83ad8bf465e3a453625acae7251746c61ac73e4fdcb164cc1ff6f6b449c01cc3</citedby><cites>FETCH-LOGICAL-c4503-b83ad8bf465e3a453625acae7251746c61ac73e4fdcb164cc1ff6f6b449c01cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478860/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478860/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32150067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Qing</creatorcontrib><creatorcontrib>Fang, Guiju</creatorcontrib><creatorcontrib>Deng, Xinyu</creatorcontrib><creatorcontrib>Zhang, Canhui</creatorcontrib><creatorcontrib>Liu, Zhixin</creatorcontrib><creatorcontrib>Peng, Zhiwen</creatorcontrib><creatorcontrib>Lai, Zibiao</creatorcontrib><creatorcontrib>Peng, Yunjuan</creatorcontrib><creatorcontrib>Wu, Jianhui</creatorcontrib><title>The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Pleural effusion (PE) remains insurmountable challenge and public health problem, requiring novel noninvasive biomarkers for accurate diagnosis. The aim of this study was to assess the clinical significance of apolipoprotein E (Apo-E) in PE, in order to determine its potential use as a diagnostic biomarker for malignant PE (MPE).PE samples were obtained from 127 patients and the etiology of PE was determined by multiple diagnostic techniques. Apo-E levels were then measured in the pleural fluid samples.58 PE patients were diagnosed with tumors, while 69 were tumor-free. Apo-E levels in MPE patients were significantly higher than those with benign PE (BPE) (P < .05). An Apo-E cut-off of 69.96 ng/mL yielded sensitivity and specificity of 79.31% and 73.91% respectively for MPE detection. The area under the curve for Apo-E was 0.793 (95% confidence interval: 0.712 to 0.860), which was smaller than that of carcinoembryonic antigen (CEA) (Z = 2.081, P<.05). In addition, the combination of Apo-E and CEA detection yielded a higher sensitivity of 87.90% and specificity of 95.65% in diagnosing MPE.In conclusion, Apo-E levels in PE may be a potential biomarker for the detection of MPE. The combined detection of Apo-E and CEA could improve the diagnostic sensitivity and specificity for MPE. These findings provide a simple and convenient method for clinical screening and detection of PE.</description><subject>Apolipoproteins E - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Exudates and Transudates - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Pleural Effusion, Malignant - diagnosis</subject><subject>Pleural Effusion, Malignant - metabolism</subject><subject>Sensitivity and Specificity</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1vFSEUhonR2NvqLzAxLN1M5Zs7GxPTVmvSxk1dE4Y53EG5MA5DG_-91FvrBwteAs95OfAi9IqSU0p6_fb6_JT8GbTnjDxBGyq56mSvxFO0IYTJTvdaHKHjUr42iGsmnqMjzqgkROkNsjcT4FsbK-DssZ1zDHOel7xCSPgCt2kMZQ1pV0OZmuABUtglbNOI9za2pU0rrilEu8JiI54j1HsF72sJOZUX6Jm3scDLBz1BXz5c3JxddlefP346e3_VOSEJ74Ytt-N28EJJ4Fa0VzBpnQXNJNVCOUWt0xyEH91AlXCOeq-8GoToHaHO8RP07uA712EPo4O0tj7MvIS9XX6YbIP59ySFyezyrdFCb7eKNIM3DwZL_l6hrGYfioMYbYJci2FcS0m04ryh_IC6JZeygH-8hhJzH465Pjf_h9OqXv_d4WPN7zQaIA7AXY7tN8u3WO9gMRPYuE6__KTuWccII4QTRbq2wzj_CTq1nJc</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Xue, Qing</creator><creator>Fang, Guiju</creator><creator>Deng, Xinyu</creator><creator>Zhang, Canhui</creator><creator>Liu, Zhixin</creator><creator>Peng, Zhiwen</creator><creator>Lai, Zibiao</creator><creator>Peng, Yunjuan</creator><creator>Wu, Jianhui</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200301</creationdate><title>The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions</title><author>Xue, Qing ; Fang, Guiju ; Deng, Xinyu ; Zhang, Canhui ; Liu, Zhixin ; Peng, Zhiwen ; Lai, Zibiao ; Peng, Yunjuan ; Wu, Jianhui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4503-b83ad8bf465e3a453625acae7251746c61ac73e4fdcb164cc1ff6f6b449c01cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apolipoproteins E - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Exudates and Transudates - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Pleural Effusion, Malignant - diagnosis</topic><topic>Pleural Effusion, Malignant - metabolism</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Qing</creatorcontrib><creatorcontrib>Fang, Guiju</creatorcontrib><creatorcontrib>Deng, Xinyu</creatorcontrib><creatorcontrib>Zhang, Canhui</creatorcontrib><creatorcontrib>Liu, Zhixin</creatorcontrib><creatorcontrib>Peng, Zhiwen</creatorcontrib><creatorcontrib>Lai, Zibiao</creatorcontrib><creatorcontrib>Peng, Yunjuan</creatorcontrib><creatorcontrib>Wu, Jianhui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Qing</au><au>Fang, Guiju</au><au>Deng, Xinyu</au><au>Zhang, Canhui</au><au>Liu, Zhixin</au><au>Peng, Zhiwen</au><au>Lai, Zibiao</au><au>Peng, Yunjuan</au><au>Wu, Jianhui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>99</volume><issue>10</issue><spage>e19320</spage><epage>e19320</epage><pages>e19320-e19320</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Pleural effusion (PE) remains insurmountable challenge and public health problem, requiring novel noninvasive biomarkers for accurate diagnosis. The aim of this study was to assess the clinical significance of apolipoprotein E (Apo-E) in PE, in order to determine its potential use as a diagnostic biomarker for malignant PE (MPE).PE samples were obtained from 127 patients and the etiology of PE was determined by multiple diagnostic techniques. Apo-E levels were then measured in the pleural fluid samples.58 PE patients were diagnosed with tumors, while 69 were tumor-free. Apo-E levels in MPE patients were significantly higher than those with benign PE (BPE) (P < .05). An Apo-E cut-off of 69.96 ng/mL yielded sensitivity and specificity of 79.31% and 73.91% respectively for MPE detection. The area under the curve for Apo-E was 0.793 (95% confidence interval: 0.712 to 0.860), which was smaller than that of carcinoembryonic antigen (CEA) (Z = 2.081, P<.05). In addition, the combination of Apo-E and CEA detection yielded a higher sensitivity of 87.90% and specificity of 95.65% in diagnosing MPE.In conclusion, Apo-E levels in PE may be a potential biomarker for the detection of MPE. The combined detection of Apo-E and CEA could improve the diagnostic sensitivity and specificity for MPE. These findings provide a simple and convenient method for clinical screening and detection of PE.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>32150067</pmid><doi>10.1097/MD.0000000000019320</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Apolipoproteins E - metabolism Biomarkers, Tumor - metabolism Exudates and Transudates - metabolism Female Humans Male Middle Aged Observational Study Pleural Effusion, Malignant - diagnosis Pleural Effusion, Malignant - metabolism Sensitivity and Specificity |
| title | The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions |
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