Fractional amplitude of low frequency fluctuation in drug-naïve first-episode patients with anorexia nervosa: A resting-state fMRI study
To characterize the fractional amplitude of low-frequency fluctuation (fALFF) in drug-naïve first-episode female patients with anorexia nervosa (AN) using resting-state functional magnetic resonance imaging (rs-fMRI).Whole brain rs-fMRI data were collected from 7 drug-naïve first-episode female pati...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-02, Vol.99 (9), p.e19300-e19300 |
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| creator | Lai, Jianbo Xu, Tingting Zhang, Haorong Xi, Caixi Zhou, Hetong Du, Yanli Jiang, Jiajun Wu, Lingling Zhang, Peifen Xu, Yi Hu, Shaohua Xu, Dongrong |
| description | To characterize the fractional amplitude of low-frequency fluctuation (fALFF) in drug-naïve first-episode female patients with anorexia nervosa (AN) using resting-state functional magnetic resonance imaging (rs-fMRI).Whole brain rs-fMRI data were collected from 7 drug-naïve first-episode female patients with DSM-5 AN and 14 age-matched healthy female controls. fALFF values were calculated and compared between the two groups using a two-sample t test. Correlation analysis between the fALFF values in the entire brain and body mass index (BMI) was performed.Compared with the healthy controls, increased fALFF values were observed in the AN patients in their right hippocampus and left superior frontal gyrus, while decreased fALFF values were observed in their left rectus and left middle occipital gyrus. Moreover, low BMI was significantly associated with decreased fALFF in the left inferior frontal gyrus but increased fALFF in the left calcarine. In particular, the z-standardized fALFF (zfALFF) value of the left rectus was positive associated with BMI.Our findings suggest that spontaneous brain activity in the frontal region, hippocampus and rectus, characterized by fALFF values, was altered in drug-naïve, first-episode female patients with AN. |
| doi_str_mv | 10.1097/MD.0000000000019300 |
| format | Article |
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Correlation analysis between the fALFF values in the entire brain and body mass index (BMI) was performed.Compared with the healthy controls, increased fALFF values were observed in the AN patients in their right hippocampus and left superior frontal gyrus, while decreased fALFF values were observed in their left rectus and left middle occipital gyrus. Moreover, low BMI was significantly associated with decreased fALFF in the left inferior frontal gyrus but increased fALFF in the left calcarine. In particular, the z-standardized fALFF (zfALFF) value of the left rectus was positive associated with BMI.Our findings suggest that spontaneous brain activity in the frontal region, hippocampus and rectus, characterized by fALFF values, was altered in drug-naïve, first-episode female patients with AN.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000019300</identifier><identifier>PMID: 32118747</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health</publisher><subject>Adolescent ; Adult ; Anorexia Nervosa - drug therapy ; Anorexia Nervosa - physiopathology ; Anorexia Nervosa - psychology ; China ; Female ; Humans ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - standards ; Magnetic Resonance Imaging - statistics & numerical data ; Observational Study ; Occipital Lobe - abnormalities ; Occipital Lobe - anatomy & histology ; Prefrontal Cortex - abnormalities ; Prefrontal Cortex - anatomy & histology</subject><ispartof>Medicine (Baltimore), 2020-02, Vol.99 (9), p.e19300-e19300</ispartof><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-d4efd7def659d5f961c67716e61de7efc86034a9598d2429f0c75ce63bbb808d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478752/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478752/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32118747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Jianbo</creatorcontrib><creatorcontrib>Xu, Tingting</creatorcontrib><creatorcontrib>Zhang, Haorong</creatorcontrib><creatorcontrib>Xi, Caixi</creatorcontrib><creatorcontrib>Zhou, Hetong</creatorcontrib><creatorcontrib>Du, Yanli</creatorcontrib><creatorcontrib>Jiang, Jiajun</creatorcontrib><creatorcontrib>Wu, Lingling</creatorcontrib><creatorcontrib>Zhang, Peifen</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Hu, Shaohua</creatorcontrib><creatorcontrib>Xu, Dongrong</creatorcontrib><title>Fractional amplitude of low frequency fluctuation in drug-naïve first-episode patients with anorexia nervosa: A resting-state fMRI study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To characterize the fractional amplitude of low-frequency fluctuation (fALFF) in drug-naïve first-episode female patients with anorexia nervosa (AN) using resting-state functional magnetic resonance imaging (rs-fMRI).Whole brain rs-fMRI data were collected from 7 drug-naïve first-episode female patients with DSM-5 AN and 14 age-matched healthy female controls. fALFF values were calculated and compared between the two groups using a two-sample t test. Correlation analysis between the fALFF values in the entire brain and body mass index (BMI) was performed.Compared with the healthy controls, increased fALFF values were observed in the AN patients in their right hippocampus and left superior frontal gyrus, while decreased fALFF values were observed in their left rectus and left middle occipital gyrus. Moreover, low BMI was significantly associated with decreased fALFF in the left inferior frontal gyrus but increased fALFF in the left calcarine. In particular, the z-standardized fALFF (zfALFF) value of the left rectus was positive associated with BMI.Our findings suggest that spontaneous brain activity in the frontal region, hippocampus and rectus, characterized by fALFF values, was altered in drug-naïve, first-episode female patients with AN.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anorexia Nervosa - drug therapy</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Anorexia Nervosa - psychology</subject><subject>China</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Observational Study</subject><subject>Occipital Lobe - abnormalities</subject><subject>Occipital Lobe - anatomy & histology</subject><subject>Prefrontal Cortex - abnormalities</subject><subject>Prefrontal Cortex - anatomy & histology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1uFDEQhS0EIkPgBEjISzad2O1uu80CKUoIiZQREoK15bHLE6Meu7HdE-YIOU0OwcXwKCH81KYW9b1XpXoIvabkiBIpjpdnR-RPUckIeYIWtGe86SXvnqIFIW3fCCm6A_Qi528VYqLtnqMD1lI6iE4s0O150qb4GPSI9WYafZkt4OjwGG-wS_B9hmB22I2zKbPeg9gHbNO8boL-ebcF7HzKpYHJ51iVU2UglIxvfLnGOsQEP7zGAdI2Zv0On-AEufiwbnLRpaqXny9xrkt3L9Ezp8cMrx76Ifp6_uHL6UVz9enj5enJVWMYJaWxHTgrLDjeS9s7yanhQlAOnFoQ4MzACeu07OVg266VjhjRG-BstVoNZLDsEL2_953m1QasqdcmPaop-Y1OOxW1V_9Ogr9W67hV9V-D6Ntq8PbBIMX6nlzUxmcD46gDxDmrlnE5DJS0e5TdoybFnBO4xzWUqH2Ianmm_g-xqt78feGj5ndq7Bf6eJy1</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Lai, Jianbo</creator><creator>Xu, Tingting</creator><creator>Zhang, Haorong</creator><creator>Xi, Caixi</creator><creator>Zhou, Hetong</creator><creator>Du, Yanli</creator><creator>Jiang, Jiajun</creator><creator>Wu, Lingling</creator><creator>Zhang, Peifen</creator><creator>Xu, Yi</creator><creator>Hu, Shaohua</creator><creator>Xu, Dongrong</creator><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200201</creationdate><title>Fractional amplitude of low frequency fluctuation in drug-naïve first-episode patients with anorexia nervosa: A resting-state fMRI study</title><author>Lai, Jianbo ; Xu, Tingting ; Zhang, Haorong ; Xi, Caixi ; Zhou, Hetong ; Du, Yanli ; Jiang, Jiajun ; Wu, Lingling ; Zhang, Peifen ; Xu, Yi ; Hu, Shaohua ; Xu, Dongrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-d4efd7def659d5f961c67716e61de7efc86034a9598d2429f0c75ce63bbb808d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anorexia Nervosa - drug therapy</topic><topic>Anorexia Nervosa - physiopathology</topic><topic>Anorexia Nervosa - psychology</topic><topic>China</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Observational Study</topic><topic>Occipital Lobe - abnormalities</topic><topic>Occipital Lobe - anatomy & histology</topic><topic>Prefrontal Cortex - abnormalities</topic><topic>Prefrontal Cortex - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Jianbo</creatorcontrib><creatorcontrib>Xu, Tingting</creatorcontrib><creatorcontrib>Zhang, Haorong</creatorcontrib><creatorcontrib>Xi, Caixi</creatorcontrib><creatorcontrib>Zhou, Hetong</creatorcontrib><creatorcontrib>Du, Yanli</creatorcontrib><creatorcontrib>Jiang, Jiajun</creatorcontrib><creatorcontrib>Wu, Lingling</creatorcontrib><creatorcontrib>Zhang, Peifen</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Hu, Shaohua</creatorcontrib><creatorcontrib>Xu, Dongrong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Jianbo</au><au>Xu, Tingting</au><au>Zhang, Haorong</au><au>Xi, Caixi</au><au>Zhou, Hetong</au><au>Du, Yanli</au><au>Jiang, Jiajun</au><au>Wu, Lingling</au><au>Zhang, Peifen</au><au>Xu, Yi</au><au>Hu, Shaohua</au><au>Xu, Dongrong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fractional amplitude of low frequency fluctuation in drug-naïve first-episode patients with anorexia nervosa: A resting-state fMRI study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>99</volume><issue>9</issue><spage>e19300</spage><epage>e19300</epage><pages>e19300-e19300</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To characterize the fractional amplitude of low-frequency fluctuation (fALFF) in drug-naïve first-episode female patients with anorexia nervosa (AN) using resting-state functional magnetic resonance imaging (rs-fMRI).Whole brain rs-fMRI data were collected from 7 drug-naïve first-episode female patients with DSM-5 AN and 14 age-matched healthy female controls. fALFF values were calculated and compared between the two groups using a two-sample t test. Correlation analysis between the fALFF values in the entire brain and body mass index (BMI) was performed.Compared with the healthy controls, increased fALFF values were observed in the AN patients in their right hippocampus and left superior frontal gyrus, while decreased fALFF values were observed in their left rectus and left middle occipital gyrus. Moreover, low BMI was significantly associated with decreased fALFF in the left inferior frontal gyrus but increased fALFF in the left calcarine. In particular, the z-standardized fALFF (zfALFF) value of the left rectus was positive associated with BMI.Our findings suggest that spontaneous brain activity in the frontal region, hippocampus and rectus, characterized by fALFF values, was altered in drug-naïve, first-episode female patients with AN.</abstract><cop>United States</cop><pub>Wolters Kluwer Health</pub><pmid>32118747</pmid><doi>10.1097/MD.0000000000019300</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Anorexia Nervosa - drug therapy Anorexia Nervosa - physiopathology Anorexia Nervosa - psychology China Female Humans Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - standards Magnetic Resonance Imaging - statistics & numerical data Observational Study Occipital Lobe - abnormalities Occipital Lobe - anatomy & histology Prefrontal Cortex - abnormalities Prefrontal Cortex - anatomy & histology |
| title | Fractional amplitude of low frequency fluctuation in drug-naïve first-episode patients with anorexia nervosa: A resting-state fMRI study |
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