Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels
[Display omitted] Healthy function of the gut microenvironment is dependent on complex interactions between the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding tissue. Misregulation of these interactions is implicated in disease. A range of tools have been develop...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2020-05, Vol.30 (10), p.127116-127116, Article 127116 |
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| container_end_page | 127116 |
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| container_issue | 10 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Wodzanowski, Kimberly A. Cassel, Samantha E. Grimes, Catherine L. Kloxin, April M. |
| description | [Display omitted]
Healthy function of the gut microenvironment is dependent on complex interactions between the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding tissue. Misregulation of these interactions is implicated in disease. A range of tools have been developed to study these interactions, from mechanistic studies to therapeutic evaluation. In this Digest, we highlight select tools at the cellular and molecular level for probing specific cell-microenvironment interactions. Approaches are overviewed for controlling and probing cell-cell interactions, from transwell and microfluidic devices to engineered bacterial peptidoglycan fragments, and cell-matrix interactions, from three-dimensional scaffolds to chemical handles for in situ modifications. |
| doi_str_mv | 10.1016/j.bmcl.2020.127116 |
| format | Article |
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Healthy function of the gut microenvironment is dependent on complex interactions between the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding tissue. Misregulation of these interactions is implicated in disease. A range of tools have been developed to study these interactions, from mechanistic studies to therapeutic evaluation. In this Digest, we highlight select tools at the cellular and molecular level for probing specific cell-microenvironment interactions. Approaches are overviewed for controlling and probing cell-cell interactions, from transwell and microfluidic devices to engineered bacterial peptidoglycan fragments, and cell-matrix interactions, from three-dimensional scaffolds to chemical handles for in situ modifications.</description><identifier>ISSN: 0960-894X</identifier><identifier>ISSN: 1464-3405</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2020.127116</identifier><identifier>PMID: 32223923</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bacteria - chemistry ; Bacteria - growth & development ; Bacteria - metabolism ; Bacterial peptidoglycan ; Biomaterials ; Bioorthogonal chemistry ; Cell-matrix interactions ; Cellular Microenvironment ; Co-culture ; Extracellular Matrix - metabolism ; Fluorescent Dyes - chemistry ; Gastrointestinal ; Host-bacteria interactions ; Host-Parasite Interactions ; Humans ; Immunity, Innate ; Intestines - cytology ; Intestines - microbiology ; Models, Biological ; Synthetic culture models</subject><ispartof>Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (10), p.127116-127116, Article 127116</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-49d3d3ed9b7db9e2bb01edeafaa7291bf452f4c8980c959e2c6b98309a73414f3</citedby><cites>FETCH-LOGICAL-c455t-49d3d3ed9b7db9e2bb01edeafaa7291bf452f4c8980c959e2c6b98309a73414f3</cites><orcidid>0000-0002-4594-2953 ; 0000-0002-0586-2879 ; 0000-0001-9591-5526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2020.127116$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32223923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wodzanowski, Kimberly A.</creatorcontrib><creatorcontrib>Cassel, Samantha E.</creatorcontrib><creatorcontrib>Grimes, Catherine L.</creatorcontrib><creatorcontrib>Kloxin, April M.</creatorcontrib><title>Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Healthy function of the gut microenvironment is dependent on complex interactions between the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding tissue. Misregulation of these interactions is implicated in disease. A range of tools have been developed to study these interactions, from mechanistic studies to therapeutic evaluation. In this Digest, we highlight select tools at the cellular and molecular level for probing specific cell-microenvironment interactions. 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Healthy function of the gut microenvironment is dependent on complex interactions between the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding tissue. Misregulation of these interactions is implicated in disease. A range of tools have been developed to study these interactions, from mechanistic studies to therapeutic evaluation. In this Digest, we highlight select tools at the cellular and molecular level for probing specific cell-microenvironment interactions. Approaches are overviewed for controlling and probing cell-cell interactions, from transwell and microfluidic devices to engineered bacterial peptidoglycan fragments, and cell-matrix interactions, from three-dimensional scaffolds to chemical handles for in situ modifications.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32223923</pmid><doi>10.1016/j.bmcl.2020.127116</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4594-2953</orcidid><orcidid>https://orcid.org/0000-0002-0586-2879</orcidid><orcidid>https://orcid.org/0000-0001-9591-5526</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Bacteria - chemistry Bacteria - growth & development Bacteria - metabolism Bacterial peptidoglycan Biomaterials Bioorthogonal chemistry Cell-matrix interactions Cellular Microenvironment Co-culture Extracellular Matrix - metabolism Fluorescent Dyes - chemistry Gastrointestinal Host-bacteria interactions Host-Parasite Interactions Humans Immunity, Innate Intestines - cytology Intestines - microbiology Models, Biological Synthetic culture models |
| title | Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels |
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