Advances in Precision Oncology: Targeted Thorium-227 Conjugates As a New Modality in Targeted Alpha Therapy

Targeted α therapy (TAT) offers the potential for the targeted delivery of potent α-particle-emitting radionuclides that emit high linear energy transfer radiation. This leads to a densely ionizing radiation track over a short path. Localized radiation induces cytotoxic, difficult-to-repair, cluster...

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Veröffentlicht in:	Cancer biotherapy & radiopharmaceuticals 2020-09, Vol.35 (7), p.497-510
Hauptverfasser:	Hagemann, Urs B, Wickstroem, Katrine, Hammer, Stefanie, Bjerke, Roger M, Zitzmann-Kolbe, Sabine, Ryan, Olav B, Karlsson, Jenny, Scholz, Arne, Hennekes, Hartwig, Mumberg, Dominik, Cuthbertson, Alan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alarmins - metabolism Alpha Particles - therapeutic use Antigens Ataxia telangiectasia Ataxia telangiectasia mutated protein Blood cancer Cancer therapies Castration CD22 antigen CD70 antigen Cell death Chelating agents Chelating Agents - chemistry Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA Damage - radiation effects DNA repair Fibroblast growth factor receptor 2 Hematologic Neoplasms - genetics Hematologic Neoplasms - immunology Hematologic Neoplasms - pathology Hematologic Neoplasms - radiotherapy Humans Immunoconjugates - chemistry Immunoconjugates - therapeutic use Immunogenic Cell Death - radiation effects Immunogenicity Ionizing radiation Kidney cancer Mesothelioma Metastases Oncology Patients Precision medicine Precision Medicine - methods Prostate cancer Pyridones - chemistry Radioisotopes Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacology Radiopharmaceuticals - therapeutic use Radium Renal cell carcinoma Reviews Ribose Solid tumors Thorium Thorium - chemistry Thorium - pharmacology Thorium - therapeutic use Treatment Outcome
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