Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake

Ca2+ uptake by mitochondria regulates bioenergetics, apoptosis, and Ca2+ signaling. The primary pathway for mitochondrial Ca2+ uptake is the mitochondrial calcium uniporter (MCU), a Ca2+-selective ion channel in the inner mitochondrial membrane. MCU-mediated Ca2+ uptake is driven by the sizable inne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-09, Vol.117 (35), p.21731-21739
Hauptverfasser:	Vais, Horia, Payne, Riley, Paudel, Usha, Li, Carmen, Foskett, J. Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding Bioenergetics Biological Sciences Calcium (mitochondrial) Calcium influx Calcium ions Calcium permeability Calcium signalling Cell death Channel gating Electron transport Ion channels Membrane permeability Membrane potential Membranes Mitochondria Mitochondrial permeability transition pore Regulation Regulatory mechanisms (biology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!