KAT5 acetylates cGAS to promote innate immune response to DNA virus

The DNA sensor cGMP-AMP synthase (cGAS) senses cytosolic microbial or self DNA to initiate a MITA/STING-dependent innate immune response. cGAS is regulated by various posttranslational modifications at its C-terminal catalytic domain. Whether and how its N-terminal unstructured domain is regulated b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-09, Vol.117 (35), p.21568-21575
Hauptverfasser:	Song, Ze-Min, Lin, Heng, Yi, Xue-Mei, Guo, Wei, Hu, Ming-Ming, Shu, Hong-Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferase Animals Biological Sciences Cyclic GMP Cyclic GMP - metabolism Cytokines Deoxyribonucleic acid DNA DNA Virus Infections - genetics DNA Virus Infections - immunology DNA Virus Infections - metabolism DNA Viruses - genetics DNA Viruses - immunology Domains Female HEK293 Cells HeLa Cells Host-Pathogen Interactions Humans Immune response Immune system Immunity, Innate Innate immunity Interferon-beta - immunology Lysine Lysine Acetyltransferase 5 - genetics Lysine Acetyltransferase 5 - immunology Lysine Acetyltransferase 5 - metabolism Male Mice Mice, Knockout Microorganisms Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nucleotidyltransferases - genetics Nucleotidyltransferases - immunology Nucleotidyltransferases - metabolism Protein Processing, Post-Translational Signal Transduction Transcription Viral Proteins - metabolism Viruses
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