TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study
The inflammatory process is known to increase the risk of gastric carcinogenesis, and both genetic and dietary factors are associated with inflammation. In the present study of 1,125 participants (373 cases and 752 controls), we determined whether the dietary inflammatory index (DII) is associated w...
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| description | The inflammatory process is known to increase the risk of gastric carcinogenesis, and both genetic and dietary factors are associated with inflammation. In the present study of 1,125 participants (373 cases and 752 controls), we determined whether the dietary inflammatory index (DII) is associated with the risk of gastric cancer (GC) and investigated whether a
TNF
polymorphism (rs1799964) modifies this association. Semi-quantitative food frequency questionnaire derived data were used to calculate the DII scores. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic models adjusted for confounders. When we stratified the data by sex, the association between GC and the DII was significant only among the women (OR, 2.27; 95% CI 1.25–4.19), and the DII effect on the risk of GC differed depending on the
TNF
genotype (OR, 2.30; 95% CI 1.27–4.24 in TT genotype; OR, 0.78; 95% CI 0.37–1.65 in CC + CT, p for interaction = 0.035). Furthermore, the association between the DII and GC was significant in the
Helicobacter pylori
-positive group; similarly, the effect differed based on the
TNF
genotype (OR, 1.76; 95% CI 1.13–2.73 in TT genotype; OR,0.98; 95% CI 0.54–1.77 in CT + CC, p for interaction = 0.034). In conclusion, rs1799964 may modify the effect of the DII on GC. |
| doi_str_mv | 10.1038/s41598-020-71433-9 |
| format | Article |
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TNF
polymorphism (rs1799964) modifies this association. Semi-quantitative food frequency questionnaire derived data were used to calculate the DII scores. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic models adjusted for confounders. When we stratified the data by sex, the association between GC and the DII was significant only among the women (OR, 2.27; 95% CI 1.25–4.19), and the DII effect on the risk of GC differed depending on the
TNF
genotype (OR, 2.30; 95% CI 1.27–4.24 in TT genotype; OR, 0.78; 95% CI 0.37–1.65 in CC + CT, p for interaction = 0.035). Furthermore, the association between the DII and GC was significant in the
Helicobacter pylori
-positive group; similarly, the effect differed based on the
TNF
genotype (OR, 1.76; 95% CI 1.13–2.73 in TT genotype; OR,0.98; 95% CI 0.54–1.77 in CT + CC, p for interaction = 0.034). In conclusion, rs1799964 may modify the effect of the DII on GC.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-71433-9</identifier><identifier>PMID: 32883994</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/2324 ; 692/4028/67/1504/1829 ; Atomic force microscopy ; Carbon dioxide ; Carcinogenesis ; Case-Control Studies ; Diet - adverse effects ; Female ; Follow-Up Studies ; Gas separation ; Gastric cancer ; Global warming ; Humanities and Social Sciences ; Humans ; Inflammation - complications ; Inflammation - genetics ; Male ; Microscopy ; Middle Aged ; multidisciplinary ; Nanoparticles ; Polyelectrolytes ; Polymorphism, Genetic ; Polystyrene ; Prognosis ; Scanning electron microscopy ; Science ; Science (multidisciplinary) ; Self-assembly ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Tumor Necrosis Factor-alpha - genetics</subject><ispartof>Scientific reports, 2020-09, Vol.10 (1), p.14590, Article 14590</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-e2e338d4057c3cecb57d747862539beaa1e529c4152df8d6208188f41e0fc1e03</citedby><cites>FETCH-LOGICAL-c522t-e2e338d4057c3cecb57d747862539beaa1e529c4152df8d6208188f41e0fc1e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471946/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471946/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32883994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jeeeun</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Choi, Il Ju</creatorcontrib><creatorcontrib>Kim, Young-Il</creatorcontrib><creatorcontrib>Sung, Joohon</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><title>TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The inflammatory process is known to increase the risk of gastric carcinogenesis, and both genetic and dietary factors are associated with inflammation. In the present study of 1,125 participants (373 cases and 752 controls), we determined whether the dietary inflammatory index (DII) is associated with the risk of gastric cancer (GC) and investigated whether a
TNF
polymorphism (rs1799964) modifies this association. Semi-quantitative food frequency questionnaire derived data were used to calculate the DII scores. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic models adjusted for confounders. When we stratified the data by sex, the association between GC and the DII was significant only among the women (OR, 2.27; 95% CI 1.25–4.19), and the DII effect on the risk of GC differed depending on the
TNF
genotype (OR, 2.30; 95% CI 1.27–4.24 in TT genotype; OR, 0.78; 95% CI 0.37–1.65 in CC + CT, p for interaction = 0.035). Furthermore, the association between the DII and GC was significant in the
Helicobacter pylori
-positive group; similarly, the effect differed based on the
TNF
genotype (OR, 1.76; 95% CI 1.13–2.73 in TT genotype; OR,0.98; 95% CI 0.54–1.77 in CT + CC, p for interaction = 0.034). In conclusion, rs1799964 may modify the effect of the DII on GC.</description><subject>631/67/2324</subject><subject>692/4028/67/1504/1829</subject><subject>Atomic force microscopy</subject><subject>Carbon dioxide</subject><subject>Carcinogenesis</subject><subject>Case-Control Studies</subject><subject>Diet - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gas separation</subject><subject>Gastric cancer</subject><subject>Global warming</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Inflammation - genetics</subject><subject>Male</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Polyelectrolytes</subject><subject>Polymorphism, Genetic</subject><subject>Polystyrene</subject><subject>Prognosis</subject><subject>Scanning electron microscopy</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Self-assembly</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UT1vFDEQtRARiZL8AQpkiQaKJf7aW7tBQhEBpCg0obZ89vhuo931YfsQ21HS8w_5JUzuQnQUuLBnPG_efDxCnnP2hjOpL4rirdENE6zpuJKyMU_IiWCqbYQU4umBfUzOS7ljeFphFDfPyLEUWktj1An5eXtzRVcwQe093aRhHlPerPsy0le58M4Ys1Cv6ehmOqbQx5nWNVCIEXylKe680EN1eab9FAc3jq6mnRPgO00TXblSM3J7N3nI-E8d2gV-__jl01RzGmip2zCfkaPohgLnD-8p-XL1_vbyY3P9-cOny3fXjW-FqA0IkFIHxdrOSw9-2XahU51eiFaaJTjHAaf0uBwRog4LwTTXOioOLHq85Cl5u-fdbJcjBA_YgxvsJvcjDmGT6-2_kalf21X6ZrEKN2qBBC8fCHL6uoVS7V3a5gl7tlwbLH6_WESJPcrnVEqG-FiBM3svoN0LaFFAuxPQGkx6cdjbY8pfuRAg94CCoWkF-aD2_2n_AJZwqKU</recordid><startdate>20200903</startdate><enddate>20200903</enddate><creator>Kim, Jeeeun</creator><creator>Lee, Jeonghee</creator><creator>Choi, Il Ju</creator><creator>Kim, Young-Il</creator><creator>Sung, Joohon</creator><creator>Kim, Jeongseon</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20200903</creationdate><title>TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study</title><author>Kim, Jeeeun ; Lee, Jeonghee ; Choi, Il Ju ; Kim, Young-Il ; Sung, Joohon ; Kim, Jeongseon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-e2e338d4057c3cecb57d747862539beaa1e529c4152df8d6208188f41e0fc1e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/67/2324</topic><topic>692/4028/67/1504/1829</topic><topic>Atomic force microscopy</topic><topic>Carbon dioxide</topic><topic>Carcinogenesis</topic><topic>Case-Control Studies</topic><topic>Diet - adverse effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gas separation</topic><topic>Gastric cancer</topic><topic>Global warming</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Inflammation - genetics</topic><topic>Male</topic><topic>Microscopy</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Nanoparticles</topic><topic>Polyelectrolytes</topic><topic>Polymorphism, Genetic</topic><topic>Polystyrene</topic><topic>Prognosis</topic><topic>Scanning electron microscopy</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Self-assembly</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jeeeun</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Choi, Il Ju</creatorcontrib><creatorcontrib>Kim, Young-Il</creatorcontrib><creatorcontrib>Sung, Joohon</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jeeeun</au><au>Lee, Jeonghee</au><au>Choi, Il Ju</au><au>Kim, Young-Il</au><au>Sung, Joohon</au><au>Kim, Jeongseon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-09-03</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>14590</spage><pages>14590-</pages><artnum>14590</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The inflammatory process is known to increase the risk of gastric carcinogenesis, and both genetic and dietary factors are associated with inflammation. In the present study of 1,125 participants (373 cases and 752 controls), we determined whether the dietary inflammatory index (DII) is associated with the risk of gastric cancer (GC) and investigated whether a
TNF
polymorphism (rs1799964) modifies this association. Semi-quantitative food frequency questionnaire derived data were used to calculate the DII scores. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic models adjusted for confounders. When we stratified the data by sex, the association between GC and the DII was significant only among the women (OR, 2.27; 95% CI 1.25–4.19), and the DII effect on the risk of GC differed depending on the
TNF
genotype (OR, 2.30; 95% CI 1.27–4.24 in TT genotype; OR, 0.78; 95% CI 0.37–1.65 in CC + CT, p for interaction = 0.035). Furthermore, the association between the DII and GC was significant in the
Helicobacter pylori
-positive group; similarly, the effect differed based on the
TNF
genotype (OR, 1.76; 95% CI 1.13–2.73 in TT genotype; OR,0.98; 95% CI 0.54–1.77 in CT + CC, p for interaction = 0.034). In conclusion, rs1799964 may modify the effect of the DII on GC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32883994</pmid><doi>10.1038/s41598-020-71433-9</doi><oa>free_for_read</oa></addata></record> |
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| source | Nature Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 631/67/2324 692/4028/67/1504/1829 Atomic force microscopy Carbon dioxide Carcinogenesis Case-Control Studies Diet - adverse effects Female Follow-Up Studies Gas separation Gastric cancer Global warming Humanities and Social Sciences Humans Inflammation - complications Inflammation - genetics Male Microscopy Middle Aged multidisciplinary Nanoparticles Polyelectrolytes Polymorphism, Genetic Polystyrene Prognosis Scanning electron microscopy Science Science (multidisciplinary) Self-assembly Stomach Neoplasms - genetics Stomach Neoplasms - pathology Tumor Necrosis Factor-alpha - genetics |
| title | TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study |
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