Implementation of Stereotactic Accelerated Partial Breast Irradiation Using Cyber-Knife – Technical Considerations and Early Experiences of a Phase II Clinical Study
To report the implementation, dosimetric results of and early experiences with stereotactic accelerated partial breast irradiation (SAPBI) following breast conserving surgery (BCS) for postmenopausal low-risk St I-II invasive breast cancer (IBC) patients. Between November 2018 and August 2019, 27 pa...
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creator | Mészáros, Norbert Smanykó, Viktor Major, Tibor Stelczer, Gábor Jánváry, Levente Kovács, Eszter Mária, Bahéri Zaka, Zoltán Pukancsik, Dávid Takácsi-Nagy, Zoltán Polgár, Csaba |
description | To report the implementation, dosimetric results of and early experiences with stereotactic accelerated partial breast irradiation (SAPBI) following breast conserving surgery (BCS) for postmenopausal low-risk St I-II invasive breast cancer (IBC) patients. Between November 2018 and August 2019, 27 patients were registered in our phase II prospective study. SAPBI was performed with Cyber-Knife (CK) M6 machine, in 4 daily fractions of 6.25 Gy to a total dose of 25 Gy. Respiratory movements were followed with implanted gold markers and Synchrony system. Corrections for patient displacement and respiratory movement during treatment were performed with the robotic arm. Early side effects, cosmetic results, and dosimetric parameters were assessed. The average volume of the surgical cavity, clinical target volume (CTV), and planning target volume (PTV_EVAL) were 8.1 cm
3
(range: 1.75–27.3 cm
3
), 55.3 cm
3
(range: 26.2–103.5 cm
3
), and 75.7 cm
3
(range: 40–135.4 cm
3
), respectively. The mean value of the PTV_eval/whole breast volume ratio was 0.09 (range: 0.04–0.19). No grade 2 or worst acute side-effect was detected. Grade 1 (G1) erythema occurred in 6 (22.2%) patients, while G1 oedema was reported by 3 (11.1%) cases. G1 pain was observed in 1 (3.4%) patient. Cosmetic result were excellent in 17 (62.9%) and good in 10 (37.1%) patients. SAPBI with CK is a suitable and practicable technique for the delivery of APBI after BCS for low-risk, St. I-II. IBC. Our early findings are encouraging, CK-SAPBI performed with four daily fractions is convenient and perfectly tolerated by the patients. |
doi_str_mv | 10.1007/s12253-020-00821-3 |
format | Article |
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3
(range: 1.75–27.3 cm
3
), 55.3 cm
3
(range: 26.2–103.5 cm
3
), and 75.7 cm
3
(range: 40–135.4 cm
3
), respectively. The mean value of the PTV_eval/whole breast volume ratio was 0.09 (range: 0.04–0.19). No grade 2 or worst acute side-effect was detected. Grade 1 (G1) erythema occurred in 6 (22.2%) patients, while G1 oedema was reported by 3 (11.1%) cases. G1 pain was observed in 1 (3.4%) patient. Cosmetic result were excellent in 17 (62.9%) and good in 10 (37.1%) patients. SAPBI with CK is a suitable and practicable technique for the delivery of APBI after BCS for low-risk, St. I-II. IBC. Our early findings are encouraging, CK-SAPBI performed with four daily fractions is convenient and perfectly tolerated by the patients.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-020-00821-3</identifier><identifier>PMID: 32472440</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Arm ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Cancer Research ; Edema ; Erythema ; Immunology ; Invasiveness ; Mastectomy ; Oncology ; Original ; Original Article ; Pathology ; Patients ; Post-menopause ; Radiation ; Robotic surgery ; Side effects ; Surgery</subject><ispartof>Pathology oncology research, 2020-10, Vol.26 (4), p.2307-2313</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9e2e6af878664b1dc738f9cb0c69eeed47855d303a39602d46a740bf0fbd0e5f3</citedby><cites>FETCH-LOGICAL-c474t-9e2e6af878664b1dc738f9cb0c69eeed47855d303a39602d46a740bf0fbd0e5f3</cites><orcidid>0000-0002-1570-7565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-020-00821-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-020-00821-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32472440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mészáros, Norbert</creatorcontrib><creatorcontrib>Smanykó, Viktor</creatorcontrib><creatorcontrib>Major, Tibor</creatorcontrib><creatorcontrib>Stelczer, Gábor</creatorcontrib><creatorcontrib>Jánváry, Levente</creatorcontrib><creatorcontrib>Kovács, Eszter</creatorcontrib><creatorcontrib>Mária, Bahéri</creatorcontrib><creatorcontrib>Zaka, Zoltán</creatorcontrib><creatorcontrib>Pukancsik, Dávid</creatorcontrib><creatorcontrib>Takácsi-Nagy, Zoltán</creatorcontrib><creatorcontrib>Polgár, Csaba</creatorcontrib><title>Implementation of Stereotactic Accelerated Partial Breast Irradiation Using Cyber-Knife – Technical Considerations and Early Experiences of a Phase II Clinical Study</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>To report the implementation, dosimetric results of and early experiences with stereotactic accelerated partial breast irradiation (SAPBI) following breast conserving surgery (BCS) for postmenopausal low-risk St I-II invasive breast cancer (IBC) patients. Between November 2018 and August 2019, 27 patients were registered in our phase II prospective study. SAPBI was performed with Cyber-Knife (CK) M6 machine, in 4 daily fractions of 6.25 Gy to a total dose of 25 Gy. Respiratory movements were followed with implanted gold markers and Synchrony system. Corrections for patient displacement and respiratory movement during treatment were performed with the robotic arm. Early side effects, cosmetic results, and dosimetric parameters were assessed. The average volume of the surgical cavity, clinical target volume (CTV), and planning target volume (PTV_EVAL) were 8.1 cm
3
(range: 1.75–27.3 cm
3
), 55.3 cm
3
(range: 26.2–103.5 cm
3
), and 75.7 cm
3
(range: 40–135.4 cm
3
), respectively. The mean value of the PTV_eval/whole breast volume ratio was 0.09 (range: 0.04–0.19). No grade 2 or worst acute side-effect was detected. Grade 1 (G1) erythema occurred in 6 (22.2%) patients, while G1 oedema was reported by 3 (11.1%) cases. G1 pain was observed in 1 (3.4%) patient. Cosmetic result were excellent in 17 (62.9%) and good in 10 (37.1%) patients. SAPBI with CK is a suitable and practicable technique for the delivery of APBI after BCS for low-risk, St. I-II. IBC. Our early findings are encouraging, CK-SAPBI performed with four daily fractions is convenient and perfectly tolerated by the patients.</description><subject>Arm</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Cancer Research</subject><subject>Edema</subject><subject>Erythema</subject><subject>Immunology</subject><subject>Invasiveness</subject><subject>Mastectomy</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Patients</subject><subject>Post-menopause</subject><subject>Radiation</subject><subject>Robotic surgery</subject><subject>Side effects</subject><subject>Surgery</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kstu1DAUhiMEoqXwAiyQJTZsAr4ljjdI7WiAiEpUaru2HPtkxlXGGWwHMTvegYfgvXgSHFLKZcHKls73_-daFE8JfkkwFq8iobRiJaa4xLihpGT3imNSMVrSBov7-U-JLLms6qPiUYw3OItqWT8sjhjlgnKOj4tv7W4_wA580smNHo09ukwQYEzaJGfQqTEwQNAJLLrQITk9oLMAOibUhqCtW2TX0fkNWh06COV773pA3798RVdgtt6ZLFmNPjo7-2Q6Iu0tWuswHND68x6CA28gzrk1utjqCKht0Wpwi_YyTfbwuHjQ6yHCk9v3pLh-s75avSvPP7xtV6fnpeGCp1IChVr3jWjqmnfEGsGaXpoOm1oCgOWiqSrLMNNM1phaXmvBcdfjvrMYqp6dFK8X3_3U7cCaPJigB7UPbqfDQY3aqb8j3m3VZvykBBeENCwbvLg1COPHCWJSOxfzDAftYZyiohw3RDJCREaf_4PejFPwuT01LwdTLqXMFF0oE8YYA_R3xRCs5jtQyx2ofAfq5x2ouYpnf7ZxJ_m1-AywBYg55DcQfuf-j-0Pt-rB_g</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Mészáros, Norbert</creator><creator>Smanykó, Viktor</creator><creator>Major, Tibor</creator><creator>Stelczer, Gábor</creator><creator>Jánváry, Levente</creator><creator>Kovács, Eszter</creator><creator>Mária, Bahéri</creator><creator>Zaka, Zoltán</creator><creator>Pukancsik, Dávid</creator><creator>Takácsi-Nagy, Zoltán</creator><creator>Polgár, Csaba</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1570-7565</orcidid></search><sort><creationdate>20201001</creationdate><title>Implementation of Stereotactic Accelerated Partial Breast Irradiation Using Cyber-Knife – Technical Considerations and Early Experiences of a Phase II Clinical Study</title><author>Mészáros, Norbert ; Smanykó, Viktor ; Major, Tibor ; Stelczer, Gábor ; Jánváry, Levente ; Kovács, Eszter ; Mária, Bahéri ; Zaka, Zoltán ; Pukancsik, Dávid ; Takácsi-Nagy, Zoltán ; Polgár, Csaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9e2e6af878664b1dc738f9cb0c69eeed47855d303a39602d46a740bf0fbd0e5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Arm</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Cancer Research</topic><topic>Edema</topic><topic>Erythema</topic><topic>Immunology</topic><topic>Invasiveness</topic><topic>Mastectomy</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Patients</topic><topic>Post-menopause</topic><topic>Radiation</topic><topic>Robotic surgery</topic><topic>Side effects</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mészáros, Norbert</creatorcontrib><creatorcontrib>Smanykó, Viktor</creatorcontrib><creatorcontrib>Major, Tibor</creatorcontrib><creatorcontrib>Stelczer, Gábor</creatorcontrib><creatorcontrib>Jánváry, Levente</creatorcontrib><creatorcontrib>Kovács, Eszter</creatorcontrib><creatorcontrib>Mária, Bahéri</creatorcontrib><creatorcontrib>Zaka, Zoltán</creatorcontrib><creatorcontrib>Pukancsik, Dávid</creatorcontrib><creatorcontrib>Takácsi-Nagy, Zoltán</creatorcontrib><creatorcontrib>Polgár, Csaba</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mészáros, Norbert</au><au>Smanykó, Viktor</au><au>Major, Tibor</au><au>Stelczer, Gábor</au><au>Jánváry, Levente</au><au>Kovács, Eszter</au><au>Mária, Bahéri</au><au>Zaka, Zoltán</au><au>Pukancsik, Dávid</au><au>Takácsi-Nagy, Zoltán</au><au>Polgár, Csaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implementation of Stereotactic Accelerated Partial Breast Irradiation Using Cyber-Knife – Technical Considerations and Early Experiences of a Phase II Clinical Study</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>26</volume><issue>4</issue><spage>2307</spage><epage>2313</epage><pages>2307-2313</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>To report the implementation, dosimetric results of and early experiences with stereotactic accelerated partial breast irradiation (SAPBI) following breast conserving surgery (BCS) for postmenopausal low-risk St I-II invasive breast cancer (IBC) patients. Between November 2018 and August 2019, 27 patients were registered in our phase II prospective study. SAPBI was performed with Cyber-Knife (CK) M6 machine, in 4 daily fractions of 6.25 Gy to a total dose of 25 Gy. Respiratory movements were followed with implanted gold markers and Synchrony system. Corrections for patient displacement and respiratory movement during treatment were performed with the robotic arm. Early side effects, cosmetic results, and dosimetric parameters were assessed. The average volume of the surgical cavity, clinical target volume (CTV), and planning target volume (PTV_EVAL) were 8.1 cm
3
(range: 1.75–27.3 cm
3
), 55.3 cm
3
(range: 26.2–103.5 cm
3
), and 75.7 cm
3
(range: 40–135.4 cm
3
), respectively. The mean value of the PTV_eval/whole breast volume ratio was 0.09 (range: 0.04–0.19). No grade 2 or worst acute side-effect was detected. Grade 1 (G1) erythema occurred in 6 (22.2%) patients, while G1 oedema was reported by 3 (11.1%) cases. G1 pain was observed in 1 (3.4%) patient. Cosmetic result were excellent in 17 (62.9%) and good in 10 (37.1%) patients. SAPBI with CK is a suitable and practicable technique for the delivery of APBI after BCS for low-risk, St. I-II. IBC. Our early findings are encouraging, CK-SAPBI performed with four daily fractions is convenient and perfectly tolerated by the patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32472440</pmid><doi>10.1007/s12253-020-00821-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1570-7565</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Arm Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Edema Erythema Immunology Invasiveness Mastectomy Oncology Original Original Article Pathology Patients Post-menopause Radiation Robotic surgery Side effects Surgery |
title | Implementation of Stereotactic Accelerated Partial Breast Irradiation Using Cyber-Knife – Technical Considerations and Early Experiences of a Phase II Clinical Study |
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