Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury

Melatonin receptors (MTs) are potential drug targets for stroke therapy. Ramelteon is a selective melatonin receptor agonist used to treat insomnia. In this study we investigated whether ramelteon could attenuate cerebral ischemia in mice. Acute focal cerebral ischemia was induced in mice via middle...

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Veröffentlicht in:	Acta pharmacologica Sinica 2020-08, Vol.41 (8), p.1016-1024
Hauptverfasser:	Wu, Xiao-li, Lu, Shou-sheng, Liu, Meng-ru, Tang, Wei-dong, Chen, Jun-zi, Zheng, Yan-rong, Ahsan, Anil, Cao, Ming, Jiang, Lei, Hu, Wei-wei, Wu, Jia-ying, Chen, Zhong, Zhang, Xiang-nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal models Autophagy Biomedical and Life Sciences Biomedicine Brain injury Cell death Cerebral blood flow Immunology Internal Medicine Ischemia Medical Microbiology Melatonin Melatonin receptors Neuroprotection Oral administration Phagocytosis Pharmacology/Toxicology Rapamycin Signal transduction Sleep disorders Stroke Therapeutic targets TOR protein Traumatic brain injury Vaccine
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