Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2

B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited su...

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Veröffentlicht in:	Cell host & microbe 2020-10, Vol.28 (4), p.516-525.e5
Hauptverfasser:	Nielsen, Sandra C.A., Yang, Fan, Jackson, Katherine J.L., Hoh, Ramona A., Röltgen, Katharina, Jean, Grace H., Stevens, Bryan A., Lee, Ji-Yeun, Rustagi, Arjun, Rogers, Angela J., Powell, Abigail E., Hunter, Molly, Najeeb, Javaria, Otrelo-Cardoso, Ana R., Yost, Kathryn E., Daniel, Bence, Nadeau, Kari C., Chang, Howard Y., Satpathy, Ansuman T., Jardetzky, Theodore S., Kim, Peter S., Wang, Taia T., Pinsky, Benjamin A., Blish, Catherine A., Boyd, Scott D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over antibodies Antibodies, Viral - blood Antibodies, Viral - genetics Antibodies, Viral - immunology Antibody Formation antibody repertoire B cells B-Lymphocytes - immunology Betacoronavirus - genetics Betacoronavirus - immunology clonal expansion convergent antibody response Coronavirus Infections - immunology Coronavirus Infections - virology COVID-19 Female HEK293 Cells Humans Immunogenetics Immunoglobulin A - genetics Immunoglobulin A - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology immunology Male Middle Aged Pandemics Pneumonia, Viral - immunology Pneumonia, Viral - virology primary infection SARS-CoV-2 Sequence Analysis Short Spike Glycoprotein, Coronavirus - immunology
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