Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice
Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts the quality of life particularly in those individuals in whom neuropathic pain develops. Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remain...
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| Veröffentlicht in: | Journal of neurotrauma 2020-09, Vol.37 (18), p.1983-1990 |
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| container_end_page | 1990 |
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| container_issue | 18 |
| container_start_page | 1983 |
| container_title | Journal of neurotrauma |
| container_volume | 37 |
| creator | McFarlane, Katelyn Otto, Taylor E Bailey, William M Veldhorst, Amy K Donahue, Renée R Taylor, Bradley K Gensel, John C |
| description | Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts the quality of life particularly in those individuals in whom neuropathic pain develops. Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. Therefore, the objective of this study in male and female C57BL/6 mice was to evaluate the following outcomes for six weeks after a 75-kdyn thoracic contusion SCI: locomotor function using the Basso Mouse Scale (BMS); spinal cord tissue sparing and rostral-caudal lesion length; and mechanical allodynia and heat hyperalgesia using hindpaw application of Von Frey filaments or radiant heat stimuli, respectively. Although motor function was largely similar between sexes, all of the males, but only half of the females, recovered plantar stepping. Rostral-caudal lesion length was shorter in females than in males. Mechanical allodynia and heat hyperalgesia after SCI developed in all animals, regardless of sex; there were no differences in pain outcomes between sexes. We conclude that contusion SCI yields subtle sex differences in mice depending on the outcome measure but no significant differences in behavioral signs of neuropathic pain. |
| doi_str_mv | 10.1089/neu.2019.6931 |
| format | Article |
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Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. Therefore, the objective of this study in male and female C57BL/6 mice was to evaluate the following outcomes for six weeks after a 75-kdyn thoracic contusion SCI: locomotor function using the Basso Mouse Scale (BMS); spinal cord tissue sparing and rostral-caudal lesion length; and mechanical allodynia and heat hyperalgesia using hindpaw application of Von Frey filaments or radiant heat stimuli, respectively. Although motor function was largely similar between sexes, all of the males, but only half of the females, recovered plantar stepping. Rostral-caudal lesion length was shorter in females than in males. Mechanical allodynia and heat hyperalgesia after SCI developed in all animals, regardless of sex; there were no differences in pain outcomes between sexes. We conclude that contusion SCI yields subtle sex differences in mice depending on the outcome measure but no significant differences in behavioral signs of neuropathic pain.</description><identifier>ISSN: 0897-7151</identifier><identifier>EISSN: 1557-9042</identifier><identifier>DOI: 10.1089/neu.2019.6931</identifier><identifier>PMID: 32597310</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Antibiotics ; Contusions ; Drug withdrawal ; Females ; Filaments ; Gender differences ; Heat ; Heat stimuli ; Hyperalgesia ; Lesions ; Males ; Neuralgia ; Neurodegeneration ; Nonsteroidal anti-inflammatory drugs ; Original ; Pain ; Pain perception ; Quality of life ; Sex ; Sex differences ; Spinal cord injuries ; Surgery ; Surgical outcomes ; Thorax</subject><ispartof>Journal of neurotrauma, 2020-09, Vol.37 (18), p.1983-1990</ispartof><rights>Copyright Mary Ann Liebert, Inc. Sep 2020</rights><rights>Katelyn McFarlane et al., 2020; Published by Mary Ann Liebert, Inc. 2020 Katelyn McFarlane et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-49d9700b9c42469a345e99f55e457fe1edca159893213340664c9daa38479db13</citedby><cites>FETCH-LOGICAL-c415t-49d9700b9c42469a345e99f55e457fe1edca159893213340664c9daa38479db13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32597310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McFarlane, Katelyn</creatorcontrib><creatorcontrib>Otto, Taylor E</creatorcontrib><creatorcontrib>Bailey, William M</creatorcontrib><creatorcontrib>Veldhorst, Amy K</creatorcontrib><creatorcontrib>Donahue, Renée R</creatorcontrib><creatorcontrib>Taylor, Bradley K</creatorcontrib><creatorcontrib>Gensel, John C</creatorcontrib><title>Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice</title><title>Journal of neurotrauma</title><addtitle>J Neurotrauma</addtitle><description>Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts the quality of life particularly in those individuals in whom neuropathic pain develops. Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. Therefore, the objective of this study in male and female C57BL/6 mice was to evaluate the following outcomes for six weeks after a 75-kdyn thoracic contusion SCI: locomotor function using the Basso Mouse Scale (BMS); spinal cord tissue sparing and rostral-caudal lesion length; and mechanical allodynia and heat hyperalgesia using hindpaw application of Von Frey filaments or radiant heat stimuli, respectively. Although motor function was largely similar between sexes, all of the males, but only half of the females, recovered plantar stepping. Rostral-caudal lesion length was shorter in females than in males. Mechanical allodynia and heat hyperalgesia after SCI developed in all animals, regardless of sex; there were no differences in pain outcomes between sexes. We conclude that contusion SCI yields subtle sex differences in mice depending on the outcome measure but no significant differences in behavioral signs of neuropathic pain.</description><subject>Antibiotics</subject><subject>Contusions</subject><subject>Drug withdrawal</subject><subject>Females</subject><subject>Filaments</subject><subject>Gender differences</subject><subject>Heat</subject><subject>Heat stimuli</subject><subject>Hyperalgesia</subject><subject>Lesions</subject><subject>Males</subject><subject>Neuralgia</subject><subject>Neurodegeneration</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Original</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Quality of life</subject><subject>Sex</subject><subject>Sex differences</subject><subject>Spinal cord injuries</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Thorax</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU1rFEEQhhsxmDV69CoNXjxkNv05PX0RwpJoYBOF6Lnp7akxvcx2r_0hxl_vDBtD9FRQ9fBSVQ9CbyhZUtLpswB1yQjVy1Zz-gwtqJSq0USw52gxzVWjqKTH6GXOW0Iob5l6gY45k1pxShZodzEM4AqOA76FXzgGfB1LTPiyBld8DKd4DXmq-Nb_hlNsQ49voKa4t-XOO_zF-oDtUCDhVQylHtC9D3acGqnHV2Fb0z2eqGvv4BU6GuyY4fVDPUHfLi--rj41688fr1bn68YJKksjdK8VIRvtBBOttlxI0HqQEoRUA1DonaVSd5ozyrkgbSuc7q3lnVC631B-gj4ccvd1s5toCCXZ0eyT39l0b6L15t9J8Hfme_xplFCEsTng_UNAij8q5GJ2PjsYRxsg1myYoJ1inRZ8Qt_9h25jTdMDZkrQllEp5sDmQLkUc04wPC5DiZlFmkmkmUWaWeTEv316wSP91xz_A_tamH4</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>McFarlane, Katelyn</creator><creator>Otto, Taylor E</creator><creator>Bailey, William M</creator><creator>Veldhorst, Amy K</creator><creator>Donahue, Renée R</creator><creator>Taylor, Bradley K</creator><creator>Gensel, John C</creator><general>Mary Ann Liebert, Inc</general><general>Mary Ann Liebert, Inc., publishers</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200915</creationdate><title>Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice</title><author>McFarlane, Katelyn ; 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| identifier | ISSN: 0897-7151 |
| ispartof | Journal of neurotrauma, 2020-09, Vol.37 (18), p.1983-1990 |
| issn | 0897-7151 1557-9042 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Antibiotics Contusions Drug withdrawal Females Filaments Gender differences Heat Heat stimuli Hyperalgesia Lesions Males Neuralgia Neurodegeneration Nonsteroidal anti-inflammatory drugs Original Pain Pain perception Quality of life Sex Sex differences Spinal cord injuries Surgery Surgical outcomes Thorax |
| title | Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice |
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