Serum Iron and Risk of Diabetic Retinopathy
Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe th...
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| Veröffentlicht in: | Nutrients 2020-07, Vol.12 (8), p.2297 |
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| description | Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe the correlation between serum iron and the occurrence of DR.
A total of 5321 participants who underwent related examinations as part of the National Health and Nutrition Examination Survey (2005-2008) were included. DR was defined by the criteria of the Early Treatment for Diabetic Retinopathy Study based on nonmydriatic fundus photography. The cutoff point of serum iron for DR was explored by the receiver operating characteristics curve. The relationship of serum iron with the occurrence of DR was explored by multivariate logistic regression models.
Participants with DR had significantly lower serum iron than the control group. Serum iron was negatively correlated with the occurrence of DR after the adjustment of pertinent variables (an odds ratio (OR) of 0.995 (95% CI: 0.992-0.999)). After dividing serum iron into quartiles, the third quartile was associated with DR with an OR of 0.601 (95% CI: 0.418-0.863). Furthermore, the cutoff point of serum iron had an inverse relationship for the occurrence of DR with an OR of 0.766 (95% CI: 0.597-0.984).
Serum iron has an inverse association with the occurrence of DR in diabetic adults. The assessment of serum iron levels might be a part of follow-up visits with diabetic patients. |
| doi_str_mv | 10.3390/nu12082297 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7469039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2430289666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-dfe481220298b9f1c676daefc0fb3936532d4f6ddb6d0faf41668a169f4f7d403</originalsourceid><addsrcrecordid>eNpVkFtLAzEQhYMottS--ANkwTdlNbdONi-CtF4KBaHqc8huEru13dRkV-i_d0trrfMwMzAfcw4HoXOCbxiT-LZqCMUZpVIcoS7FgqYAnB0f7B3Uj3GONyWwAHaKOoyKAREi66LrVxuaZTIOvkp0ZZJpGT8T75JRqXNbl0UybXvlV7qerc_QidOLaPu72UPvjw9vw-d08vI0Ht5P0oILWqfGWZ4RSjGVWS4dKUCA0dYV2OVMMhgwargDY3Iw2GnHCUCmCUjHnTAcsx662_5dNfnSmsJWddALtQrlUoe18rpU_y9VOVMf_lsJDhK3Ej10uXsQ_FdjY63mvglV61lRzjDNJAC01NWWKoKPMVi3VyBYbbJVf9m28MWhpz36myT7Abp3c2U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430289666</pqid></control><display><type>article</type><title>Serum Iron and Risk of Diabetic Retinopathy</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Chen, Ying-Jen ; Chen, Jiann-Torng ; Tai, Ming-Cheng ; Liang, Chang-Min ; Chen, Yuan-Yuei ; Chen, Wei-Liang</creator><creatorcontrib>Chen, Ying-Jen ; Chen, Jiann-Torng ; Tai, Ming-Cheng ; Liang, Chang-Min ; Chen, Yuan-Yuei ; Chen, Wei-Liang</creatorcontrib><description>Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe the correlation between serum iron and the occurrence of DR.
A total of 5321 participants who underwent related examinations as part of the National Health and Nutrition Examination Survey (2005-2008) were included. DR was defined by the criteria of the Early Treatment for Diabetic Retinopathy Study based on nonmydriatic fundus photography. The cutoff point of serum iron for DR was explored by the receiver operating characteristics curve. The relationship of serum iron with the occurrence of DR was explored by multivariate logistic regression models.
Participants with DR had significantly lower serum iron than the control group. Serum iron was negatively correlated with the occurrence of DR after the adjustment of pertinent variables (an odds ratio (OR) of 0.995 (95% CI: 0.992-0.999)). After dividing serum iron into quartiles, the third quartile was associated with DR with an OR of 0.601 (95% CI: 0.418-0.863). Furthermore, the cutoff point of serum iron had an inverse relationship for the occurrence of DR with an OR of 0.766 (95% CI: 0.597-0.984).
Serum iron has an inverse association with the occurrence of DR in diabetic adults. The assessment of serum iron levels might be a part of follow-up visits with diabetic patients.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12082297</identifier><identifier>PMID: 32751778</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aged ; Apoptosis ; Blindness ; Cadmium ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetic retinopathy ; Diabetic Retinopathy - etiology ; Diagnostic Techniques, Ophthalmological ; Female ; Fundus Oculi ; Glucose ; Hemoglobin ; Hispanic people ; Humans ; Hypertension ; Iron ; Iron - blood ; Logistic Models ; Male ; Metabolism ; Middle Aged ; Nutrition ; Nutrition Surveys ; Photography ; Regression analysis ; Retinopathy ; Risk Factors ; ROC Curve ; Smoking</subject><ispartof>Nutrients, 2020-07, Vol.12 (8), p.2297</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-dfe481220298b9f1c676daefc0fb3936532d4f6ddb6d0faf41668a169f4f7d403</citedby><cites>FETCH-LOGICAL-c472t-dfe481220298b9f1c676daefc0fb3936532d4f6ddb6d0faf41668a169f4f7d403</cites><orcidid>0000-0003-0784-230X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469039/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469039/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32751778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ying-Jen</creatorcontrib><creatorcontrib>Chen, Jiann-Torng</creatorcontrib><creatorcontrib>Tai, Ming-Cheng</creatorcontrib><creatorcontrib>Liang, Chang-Min</creatorcontrib><creatorcontrib>Chen, Yuan-Yuei</creatorcontrib><creatorcontrib>Chen, Wei-Liang</creatorcontrib><title>Serum Iron and Risk of Diabetic Retinopathy</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe the correlation between serum iron and the occurrence of DR.
A total of 5321 participants who underwent related examinations as part of the National Health and Nutrition Examination Survey (2005-2008) were included. DR was defined by the criteria of the Early Treatment for Diabetic Retinopathy Study based on nonmydriatic fundus photography. The cutoff point of serum iron for DR was explored by the receiver operating characteristics curve. The relationship of serum iron with the occurrence of DR was explored by multivariate logistic regression models.
Participants with DR had significantly lower serum iron than the control group. Serum iron was negatively correlated with the occurrence of DR after the adjustment of pertinent variables (an odds ratio (OR) of 0.995 (95% CI: 0.992-0.999)). After dividing serum iron into quartiles, the third quartile was associated with DR with an OR of 0.601 (95% CI: 0.418-0.863). Furthermore, the cutoff point of serum iron had an inverse relationship for the occurrence of DR with an OR of 0.766 (95% CI: 0.597-0.984).
Serum iron has an inverse association with the occurrence of DR in diabetic adults. The assessment of serum iron levels might be a part of follow-up visits with diabetic patients.</description><subject>Aged</subject><subject>Apoptosis</subject><subject>Blindness</subject><subject>Cadmium</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - etiology</subject><subject>Diagnostic Techniques, Ophthalmological</subject><subject>Female</subject><subject>Fundus Oculi</subject><subject>Glucose</subject><subject>Hemoglobin</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Iron</subject><subject>Iron - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Photography</subject><subject>Regression analysis</subject><subject>Retinopathy</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Smoking</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVkFtLAzEQhYMottS--ANkwTdlNbdONi-CtF4KBaHqc8huEru13dRkV-i_d0trrfMwMzAfcw4HoXOCbxiT-LZqCMUZpVIcoS7FgqYAnB0f7B3Uj3GONyWwAHaKOoyKAREi66LrVxuaZTIOvkp0ZZJpGT8T75JRqXNbl0UybXvlV7qerc_QidOLaPu72UPvjw9vw-d08vI0Ht5P0oILWqfGWZ4RSjGVWS4dKUCA0dYV2OVMMhgwargDY3Iw2GnHCUCmCUjHnTAcsx662_5dNfnSmsJWddALtQrlUoe18rpU_y9VOVMf_lsJDhK3Ej10uXsQ_FdjY63mvglV61lRzjDNJAC01NWWKoKPMVi3VyBYbbJVf9m28MWhpz36myT7Abp3c2U</recordid><startdate>20200731</startdate><enddate>20200731</enddate><creator>Chen, Ying-Jen</creator><creator>Chen, Jiann-Torng</creator><creator>Tai, Ming-Cheng</creator><creator>Liang, Chang-Min</creator><creator>Chen, Yuan-Yuei</creator><creator>Chen, Wei-Liang</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0784-230X</orcidid></search><sort><creationdate>20200731</creationdate><title>Serum Iron and Risk of Diabetic Retinopathy</title><author>Chen, Ying-Jen ; Chen, Jiann-Torng ; Tai, Ming-Cheng ; Liang, Chang-Min ; Chen, Yuan-Yuei ; Chen, Wei-Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-dfe481220298b9f1c676daefc0fb3936532d4f6ddb6d0faf41668a169f4f7d403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Apoptosis</topic><topic>Blindness</topic><topic>Cadmium</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - etiology</topic><topic>Diagnostic Techniques, Ophthalmological</topic><topic>Female</topic><topic>Fundus Oculi</topic><topic>Glucose</topic><topic>Hemoglobin</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Iron</topic><topic>Iron - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Nutrition Surveys</topic><topic>Photography</topic><topic>Regression analysis</topic><topic>Retinopathy</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ying-Jen</creatorcontrib><creatorcontrib>Chen, Jiann-Torng</creatorcontrib><creatorcontrib>Tai, Ming-Cheng</creatorcontrib><creatorcontrib>Liang, Chang-Min</creatorcontrib><creatorcontrib>Chen, Yuan-Yuei</creatorcontrib><creatorcontrib>Chen, Wei-Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ying-Jen</au><au>Chen, Jiann-Torng</au><au>Tai, Ming-Cheng</au><au>Liang, Chang-Min</au><au>Chen, Yuan-Yuei</au><au>Chen, Wei-Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Iron and Risk of Diabetic Retinopathy</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-07-31</date><risdate>2020</risdate><volume>12</volume><issue>8</issue><spage>2297</spage><pages>2297-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Diabetic retinopathy (DR) is indicated as a major cause of blindness in the world. Emerging evidence supports the interaction of iron metabolism with diabetes. However, little research is available concerning the relationship between iron metabolism and DR. The intent of this paper is to describe the correlation between serum iron and the occurrence of DR.
A total of 5321 participants who underwent related examinations as part of the National Health and Nutrition Examination Survey (2005-2008) were included. DR was defined by the criteria of the Early Treatment for Diabetic Retinopathy Study based on nonmydriatic fundus photography. The cutoff point of serum iron for DR was explored by the receiver operating characteristics curve. The relationship of serum iron with the occurrence of DR was explored by multivariate logistic regression models.
Participants with DR had significantly lower serum iron than the control group. Serum iron was negatively correlated with the occurrence of DR after the adjustment of pertinent variables (an odds ratio (OR) of 0.995 (95% CI: 0.992-0.999)). After dividing serum iron into quartiles, the third quartile was associated with DR with an OR of 0.601 (95% CI: 0.418-0.863). Furthermore, the cutoff point of serum iron had an inverse relationship for the occurrence of DR with an OR of 0.766 (95% CI: 0.597-0.984).
Serum iron has an inverse association with the occurrence of DR in diabetic adults. The assessment of serum iron levels might be a part of follow-up visits with diabetic patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32751778</pmid><doi>10.3390/nu12082297</doi><orcidid>https://orcid.org/0000-0003-0784-230X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Apoptosis Blindness Cadmium Diabetes Diabetes mellitus Diabetes Mellitus - blood Diabetic retinopathy Diabetic Retinopathy - etiology Diagnostic Techniques, Ophthalmological Female Fundus Oculi Glucose Hemoglobin Hispanic people Humans Hypertension Iron Iron - blood Logistic Models Male Metabolism Middle Aged Nutrition Nutrition Surveys Photography Regression analysis Retinopathy Risk Factors ROC Curve Smoking |
| title | Serum Iron and Risk of Diabetic Retinopathy |
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