Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children
Malnutrition is commonly associated with immunological deregulation, increasing the risk of infectious illness and death. The objective of this work was to determine the in vitro effects of heat-killed IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nouris...
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| Veröffentlicht in: | Nutrients 2020-07, Vol.12 (8), p.2303 |
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| creator | Rocha-Ramírez, Luz María Hernández-Ochoa, Beatriz Gómez-Manzo, Saúl Marcial-Quino, Jaime Cárdenas-Rodríguez, Noemí Centeno-Leija, Sara García-Garibay, Mariano |
| description | Malnutrition is commonly associated with immunological deregulation, increasing the risk of infectious illness and death. The objective of this work was to determine the in vitro effects of heat-killed
IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nourished infected children and malnourished infected children, which was evaluated by an oxygen-dependent microbicidal mechanism assay of luminol-increase chemiluminescence and the secretion of tumor necrosis factor (TNF-α), interleukin (IL-1β), IL-6 and IL-10, as well as phagocytosis using zymosan and as its antibacterial activity against
,
and
. We found that reactive oxygen species (ROS), secretion cytokines (TNFα, IL-1β, IL-6 and IL-10 levels), phagocytosis and bactericidal capacity increased in all groups after pre-treatment with heat-killed
IMAU60214 at a ratio of 500:1 (bacteria:MDM) over 24 h compared with MDM cells without pre-treatment. The results could indicate that heat-killed
IMAU60214 is a potential candidate for regulating the immune function of macrophages. |
| doi_str_mv | 10.3390/nu12082303 |
| format | Article |
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IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nourished infected children and malnourished infected children, which was evaluated by an oxygen-dependent microbicidal mechanism assay of luminol-increase chemiluminescence and the secretion of tumor necrosis factor (TNF-α), interleukin (IL-1β), IL-6 and IL-10, as well as phagocytosis using zymosan and as its antibacterial activity against
,
and
. We found that reactive oxygen species (ROS), secretion cytokines (TNFα, IL-1β, IL-6 and IL-10 levels), phagocytosis and bactericidal capacity increased in all groups after pre-treatment with heat-killed
IMAU60214 at a ratio of 500:1 (bacteria:MDM) over 24 h compared with MDM cells without pre-treatment. The results could indicate that heat-killed
IMAU60214 is a potential candidate for regulating the immune function of macrophages.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12082303</identifier><identifier>PMID: 32751919</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Antibacterial activity ; Bacteria ; Bacterial infections ; Bacteriological Techniques ; Blood Bactericidal Activity - immunology ; Chemiluminescence ; Children ; Cytokines ; Cytokines - blood ; Cytokines - immunology ; Deregulation ; Female ; Health risks ; Heat ; Heat treatment ; Hot Temperature ; Humans ; IL-1β ; Immune response ; Immune system ; Immunology ; Infant ; Infant Nutrition Disorders - blood ; Infant Nutrition Disorders - immunology ; Infant Nutrition Disorders - microbiology ; Infections ; Interleukin 10 ; Interleukin 6 ; Interleukin-10 - blood ; Interleukin-10 - immunology ; Interleukin-1beta - blood ; Interleukin-1beta - immunology ; Interleukin-6 - blood ; Interleukin-6 - immunology ; Lacticaseibacillus casei - immunology ; Lactobacilli ; Lactobacillus casei ; Macrophages ; Macrophages - immunology ; Macrophages - microbiology ; Male ; Malnutrition ; Microbicides ; Monocytes ; Pathogens ; Phagocytosis ; Phagocytosis - immunology ; Physiology ; Pretreatment ; Probiotics ; Probiotics - pharmacology ; Reactive oxygen species ; Salmonella ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - immunology ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Viral infections</subject><ispartof>Nutrients, 2020-07, Vol.12 (8), p.2303</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3213-24b9182fc6a8e2b5d2e1976a553ec77de0bd6bcad2ecd8399c3265c736079eb83</citedby><cites>FETCH-LOGICAL-c3213-24b9182fc6a8e2b5d2e1976a553ec77de0bd6bcad2ecd8399c3265c736079eb83</cites><orcidid>0000-0003-3939-6930 ; 0000-0002-4591-7379 ; 0000-0003-2095-9182 ; 0000-0002-7204-1421 ; 0000-0002-6580-3440 ; 0000-0002-8573-4577</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468933/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468933/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32751919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocha-Ramírez, Luz María</creatorcontrib><creatorcontrib>Hernández-Ochoa, Beatriz</creatorcontrib><creatorcontrib>Gómez-Manzo, Saúl</creatorcontrib><creatorcontrib>Marcial-Quino, Jaime</creatorcontrib><creatorcontrib>Cárdenas-Rodríguez, Noemí</creatorcontrib><creatorcontrib>Centeno-Leija, Sara</creatorcontrib><creatorcontrib>García-Garibay, Mariano</creatorcontrib><title>Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Malnutrition is commonly associated with immunological deregulation, increasing the risk of infectious illness and death. The objective of this work was to determine the in vitro effects of heat-killed
IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nourished infected children and malnourished infected children, which was evaluated by an oxygen-dependent microbicidal mechanism assay of luminol-increase chemiluminescence and the secretion of tumor necrosis factor (TNF-α), interleukin (IL-1β), IL-6 and IL-10, as well as phagocytosis using zymosan and as its antibacterial activity against
,
and
. We found that reactive oxygen species (ROS), secretion cytokines (TNFα, IL-1β, IL-6 and IL-10 levels), phagocytosis and bactericidal capacity increased in all groups after pre-treatment with heat-killed
IMAU60214 at a ratio of 500:1 (bacteria:MDM) over 24 h compared with MDM cells without pre-treatment. The results could indicate that heat-killed
IMAU60214 is a potential candidate for regulating the immune function of macrophages.</description><subject>Age</subject><subject>Antibacterial activity</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Bacteriological Techniques</subject><subject>Blood Bactericidal Activity - immunology</subject><subject>Chemiluminescence</subject><subject>Children</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - immunology</subject><subject>Deregulation</subject><subject>Female</subject><subject>Health risks</subject><subject>Heat</subject><subject>Heat treatment</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>IL-1β</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infant</subject><subject>Infant Nutrition Disorders - blood</subject><subject>Infant Nutrition Disorders - immunology</subject><subject>Infant Nutrition Disorders - microbiology</subject><subject>Infections</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukin-10 - 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immunology</topic><topic>Macrophages - microbiology</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Microbicides</topic><topic>Monocytes</topic><topic>Pathogens</topic><topic>Phagocytosis</topic><topic>Phagocytosis - immunology</topic><topic>Physiology</topic><topic>Pretreatment</topic><topic>Probiotics</topic><topic>Probiotics - pharmacology</topic><topic>Reactive oxygen species</topic><topic>Salmonella</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocha-Ramírez, Luz María</creatorcontrib><creatorcontrib>Hernández-Ochoa, Beatriz</creatorcontrib><creatorcontrib>Gómez-Manzo, Saúl</creatorcontrib><creatorcontrib>Marcial-Quino, Jaime</creatorcontrib><creatorcontrib>Cárdenas-Rodríguez, Noemí</creatorcontrib><creatorcontrib>Centeno-Leija, Sara</creatorcontrib><creatorcontrib>García-Garibay, Mariano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocha-Ramírez, Luz María</au><au>Hernández-Ochoa, Beatriz</au><au>Gómez-Manzo, Saúl</au><au>Marcial-Quino, Jaime</au><au>Cárdenas-Rodríguez, Noemí</au><au>Centeno-Leija, Sara</au><au>García-Garibay, Mariano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-07-31</date><risdate>2020</risdate><volume>12</volume><issue>8</issue><spage>2303</spage><pages>2303-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Malnutrition is commonly associated with immunological deregulation, increasing the risk of infectious illness and death. The objective of this work was to determine the in vitro effects of heat-killed
IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nourished infected children and malnourished infected children, which was evaluated by an oxygen-dependent microbicidal mechanism assay of luminol-increase chemiluminescence and the secretion of tumor necrosis factor (TNF-α), interleukin (IL-1β), IL-6 and IL-10, as well as phagocytosis using zymosan and as its antibacterial activity against
,
and
. We found that reactive oxygen species (ROS), secretion cytokines (TNFα, IL-1β, IL-6 and IL-10 levels), phagocytosis and bactericidal capacity increased in all groups after pre-treatment with heat-killed
IMAU60214 at a ratio of 500:1 (bacteria:MDM) over 24 h compared with MDM cells without pre-treatment. The results could indicate that heat-killed
IMAU60214 is a potential candidate for regulating the immune function of macrophages.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32751919</pmid><doi>10.3390/nu12082303</doi><orcidid>https://orcid.org/0000-0003-3939-6930</orcidid><orcidid>https://orcid.org/0000-0002-4591-7379</orcidid><orcidid>https://orcid.org/0000-0003-2095-9182</orcidid><orcidid>https://orcid.org/0000-0002-7204-1421</orcidid><orcidid>https://orcid.org/0000-0002-6580-3440</orcidid><orcidid>https://orcid.org/0000-0002-8573-4577</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2020-07, Vol.12 (8), p.2303 |
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| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Antibacterial activity Bacteria Bacterial infections Bacteriological Techniques Blood Bactericidal Activity - immunology Chemiluminescence Children Cytokines Cytokines - blood Cytokines - immunology Deregulation Female Health risks Heat Heat treatment Hot Temperature Humans IL-1β Immune response Immune system Immunology Infant Infant Nutrition Disorders - blood Infant Nutrition Disorders - immunology Infant Nutrition Disorders - microbiology Infections Interleukin 10 Interleukin 6 Interleukin-10 - blood Interleukin-10 - immunology Interleukin-1beta - blood Interleukin-1beta - immunology Interleukin-6 - blood Interleukin-6 - immunology Lacticaseibacillus casei - immunology Lactobacilli Lactobacillus casei Macrophages Macrophages - immunology Macrophages - microbiology Male Malnutrition Microbicides Monocytes Pathogens Phagocytosis Phagocytosis - immunology Physiology Pretreatment Probiotics Probiotics - pharmacology Reactive oxygen species Salmonella Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-TNF Tumor necrosis factor-α Viral infections |
| title | Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children |
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