Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women
Older adults are frequently cited as an at-risk population for vitamin D deficiency that may in part be due to decreased cutaneous synthesis, a potentially important source of cholecalciferol (vitamin D ). Previous studies found that cutaneous D production declines with age; however, most studies ha...
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| Veröffentlicht in: | Nutrients 2020-07, Vol.12 (8), p.2237 |
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| creator | Chalcraft, Jenna R Cardinal, Linda M Wechsler, Perry J Hollis, Bruce W Gerow, Kenneth G Alexander, Brenda M Keith, Jill F Larson-Meyer, D Enette |
| description | Older adults are frequently cited as an at-risk population for vitamin D deficiency that may in part be due to decreased cutaneous synthesis, a potentially important source of cholecalciferol (vitamin D
). Previous studies found that cutaneous D
production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults.
30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20-37 (
= 18) and an older cohort (
= 12), age 51-69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D
concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort.
D
increased in response to sun exposure (time effect;
= 0.002) with a trend for a difference in D
between cohorts (time*group;
= 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D
production. D
production decreased by 13% per decade. Despite changes in D
, however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure (
> 0.10).
Serum D
concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D
. |
| doi_str_mv | 10.3390/nu12082237 |
| format | Article |
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). Previous studies found that cutaneous D
production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults.
30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20-37 (
= 18) and an older cohort (
= 12), age 51-69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D
concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort.
D
increased in response to sun exposure (time effect;
= 0.002) with a trend for a difference in D
between cohorts (time*group;
= 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D
production. D
production decreased by 13% per decade. Despite changes in D
, however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure (
> 0.10).
Serum D
concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D
.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12082237</identifier><identifier>PMID: 32727044</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Adults ; Age ; Age Factors ; Aged ; Aging ; Calciferol ; Cholecalciferol - blood ; Community ; Dietary supplements ; Exposure ; Family medical history ; Female ; Humans ; Male ; Melanoma ; Metabolism ; Metabolites ; Middle Aged ; Older people ; Public health ; Regression Analysis ; Skin - metabolism ; Skin cancer ; Sun ; Sunlight ; Sunscreen ; Time Factors ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - biosynthesis ; Vitamin D - blood ; Vitamin D Deficiency - etiology ; Vitamin D3 ; Vitamin deficiency ; Young Adult</subject><ispartof>Nutrients, 2020-07, Vol.12 (8), p.2237</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-4374fa430dc2142d2788675c18c191ac85b60f8d70938384ffd9aebefaa2e2a63</citedby><cites>FETCH-LOGICAL-c472t-4374fa430dc2142d2788675c18c191ac85b60f8d70938384ffd9aebefaa2e2a63</cites><orcidid>0000-0002-8507-6922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468901/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468901/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32727044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chalcraft, Jenna R</creatorcontrib><creatorcontrib>Cardinal, Linda M</creatorcontrib><creatorcontrib>Wechsler, Perry J</creatorcontrib><creatorcontrib>Hollis, Bruce W</creatorcontrib><creatorcontrib>Gerow, Kenneth G</creatorcontrib><creatorcontrib>Alexander, Brenda M</creatorcontrib><creatorcontrib>Keith, Jill F</creatorcontrib><creatorcontrib>Larson-Meyer, D Enette</creatorcontrib><title>Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Older adults are frequently cited as an at-risk population for vitamin D deficiency that may in part be due to decreased cutaneous synthesis, a potentially important source of cholecalciferol (vitamin D
). Previous studies found that cutaneous D
production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults.
30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20-37 (
= 18) and an older cohort (
= 12), age 51-69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D
concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort.
D
increased in response to sun exposure (time effect;
= 0.002) with a trend for a difference in D
between cohorts (time*group;
= 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D
production. D
production decreased by 13% per decade. Despite changes in D
, however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure (
> 0.10).
Serum D
concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D
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). Previous studies found that cutaneous D
production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults.
30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20-37 (
= 18) and an older cohort (
= 12), age 51-69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D
concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort.
D
increased in response to sun exposure (time effect;
= 0.002) with a trend for a difference in D
between cohorts (time*group;
= 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D
production. D
production decreased by 13% per decade. Despite changes in D
, however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure (
> 0.10).
Serum D
concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D
.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32727044</pmid><doi>10.3390/nu12082237</doi><orcidid>https://orcid.org/0000-0002-8507-6922</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adult Adults Age Age Factors Aged Aging Calciferol Cholecalciferol - blood Community Dietary supplements Exposure Family medical history Female Humans Male Melanoma Metabolism Metabolites Middle Aged Older people Public health Regression Analysis Skin - metabolism Skin cancer Sun Sunlight Sunscreen Time Factors Vitamin D Vitamin D - analogs & derivatives Vitamin D - biosynthesis Vitamin D - blood Vitamin D Deficiency - etiology Vitamin D3 Vitamin deficiency Young Adult |
| title | Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women |
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