Effects of Daily Consumption of an Aqueous Dispersion of Free-Phytosterols Nanoparticles on Individuals with Metabolic Syndrome: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial
Metabolic syndrome (MS) affects up to 40% of the population and is associated with heart failure, stroke and diabetes. Phytosterols (PS) could help to manage one or more MS criteria. The purpose of this study was to evaluate the therapeutic effect of daily supplementation of an aqueous dispersion of...
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| Veröffentlicht in: | Nutrients 2020-08, Vol.12 (8), p.2392 |
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| description | Metabolic syndrome (MS) affects up to 40% of the population and is associated with heart failure, stroke and diabetes. Phytosterols (PS) could help to manage one or more MS criteria. The purpose of this study was to evaluate the therapeutic effect of daily supplementation of an aqueous dispersion of 2 g of free-phytosterols nanoparticles in individuals with MS over six months of intervention, compared with placebo. This double-blind study included 202 participants with MS randomly assigned into phytosterol (
= 102) and placebo (
= 100) groups. Participants were assessed at baseline, 4, 12 and 24 weeks. General health questions, anthropometric measurements and blood parameters were analysed. At week 24, the proportion of participants with high triglycerides (≥150 mg/dL) in the phytosterol group was 15.65% lower than in the placebo group (
-value = 0.023). Similarly, half of the participants in the phytosterol group decreased their waist circumference up to 4 cm compared with 0 cm in the placebo group (
-value = 0.0001). We reported no adverse effects (diarrhoea or vitamin D reduction); nonetheless, almost 70% of participants in the phytosterol group self-reported an improvement in bowel habits. Daily intake of free-PS nanoparticles improved some MS criteria; therefore, it might be a promising adjuvant therapy for individuals with MS (NCT02969720). |
| doi_str_mv | 10.3390/nu12082392 |
| format | Article |
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= 102) and placebo (
= 100) groups. Participants were assessed at baseline, 4, 12 and 24 weeks. General health questions, anthropometric measurements and blood parameters were analysed. At week 24, the proportion of participants with high triglycerides (≥150 mg/dL) in the phytosterol group was 15.65% lower than in the placebo group (
-value = 0.023). Similarly, half of the participants in the phytosterol group decreased their waist circumference up to 4 cm compared with 0 cm in the placebo group (
-value = 0.0001). We reported no adverse effects (diarrhoea or vitamin D reduction); nonetheless, almost 70% of participants in the phytosterol group self-reported an improvement in bowel habits. Daily intake of free-PS nanoparticles improved some MS criteria; therefore, it might be a promising adjuvant therapy for individuals with MS (NCT02969720).</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12082392</identifier><identifier>PMID: 32785036</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescent ; Adult ; Aged ; Blood pressure ; Cholesterol ; Clinical trials ; Congestive heart failure ; Constipation - diet therapy ; Diabetes ; Diabetes mellitus ; Diarrhea ; Dietary Supplements ; Dispersion ; Double-Blind Method ; Double-blind studies ; Female ; Hemoglobin ; Humans ; Insulin resistance ; Intervention ; Intestine ; Lipoproteins ; Male ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - diet therapy ; Metabolic Syndrome - metabolism ; Middle Aged ; Nanoparticles ; Phytosterols ; Phytosterols - administration & dosage ; Phytotherapy ; Potassium ; Surfactants ; Time Factors ; Treatment Outcome ; Triglycerides ; Triglycerides - blood ; Vital signs ; Vitamin D ; Waist Circumference ; Water ; Weight control ; Young Adult</subject><ispartof>Nutrients, 2020-08, Vol.12 (8), p.2392</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-36803a6766aa759132b3eae6e27da5da582a361f9fd909f71d7d058a365f75bd3</citedby><cites>FETCH-LOGICAL-c406t-36803a6766aa759132b3eae6e27da5da582a361f9fd909f71d7d058a365f75bd3</cites><orcidid>0000-0002-8140-700X ; 0000-0001-6664-1079</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468816/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468816/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32785036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palmeiro-Silva, Yasna K</creatorcontrib><creatorcontrib>Aravena, Raúl I</creatorcontrib><creatorcontrib>Ossio, Lisette</creatorcontrib><creatorcontrib>Parro Fluxa, Javiera</creatorcontrib><title>Effects of Daily Consumption of an Aqueous Dispersion of Free-Phytosterols Nanoparticles on Individuals with Metabolic Syndrome: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Metabolic syndrome (MS) affects up to 40% of the population and is associated with heart failure, stroke and diabetes. Phytosterols (PS) could help to manage one or more MS criteria. The purpose of this study was to evaluate the therapeutic effect of daily supplementation of an aqueous dispersion of 2 g of free-phytosterols nanoparticles in individuals with MS over six months of intervention, compared with placebo. This double-blind study included 202 participants with MS randomly assigned into phytosterol (
= 102) and placebo (
= 100) groups. Participants were assessed at baseline, 4, 12 and 24 weeks. General health questions, anthropometric measurements and blood parameters were analysed. At week 24, the proportion of participants with high triglycerides (≥150 mg/dL) in the phytosterol group was 15.65% lower than in the placebo group (
-value = 0.023). Similarly, half of the participants in the phytosterol group decreased their waist circumference up to 4 cm compared with 0 cm in the placebo group (
-value = 0.0001). We reported no adverse effects (diarrhoea or vitamin D reduction); nonetheless, almost 70% of participants in the phytosterol group self-reported an improvement in bowel habits. 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Phytosterols (PS) could help to manage one or more MS criteria. The purpose of this study was to evaluate the therapeutic effect of daily supplementation of an aqueous dispersion of 2 g of free-phytosterols nanoparticles in individuals with MS over six months of intervention, compared with placebo. This double-blind study included 202 participants with MS randomly assigned into phytosterol (
= 102) and placebo (
= 100) groups. Participants were assessed at baseline, 4, 12 and 24 weeks. General health questions, anthropometric measurements and blood parameters were analysed. At week 24, the proportion of participants with high triglycerides (≥150 mg/dL) in the phytosterol group was 15.65% lower than in the placebo group (
-value = 0.023). Similarly, half of the participants in the phytosterol group decreased their waist circumference up to 4 cm compared with 0 cm in the placebo group (
-value = 0.0001). We reported no adverse effects (diarrhoea or vitamin D reduction); nonetheless, almost 70% of participants in the phytosterol group self-reported an improvement in bowel habits. Daily intake of free-PS nanoparticles improved some MS criteria; therefore, it might be a promising adjuvant therapy for individuals with MS (NCT02969720).</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32785036</pmid><doi>10.3390/nu12082392</doi><orcidid>https://orcid.org/0000-0002-8140-700X</orcidid><orcidid>https://orcid.org/0000-0001-6664-1079</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2020-08, Vol.12 (8), p.2392 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adolescent Adult Aged Blood pressure Cholesterol Clinical trials Congestive heart failure Constipation - diet therapy Diabetes Diabetes mellitus Diarrhea Dietary Supplements Dispersion Double-Blind Method Double-blind studies Female Hemoglobin Humans Insulin resistance Intervention Intestine Lipoproteins Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - diet therapy Metabolic Syndrome - metabolism Middle Aged Nanoparticles Phytosterols Phytosterols - administration & dosage Phytotherapy Potassium Surfactants Time Factors Treatment Outcome Triglycerides Triglycerides - blood Vital signs Vitamin D Waist Circumference Water Weight control Young Adult |
| title | Effects of Daily Consumption of an Aqueous Dispersion of Free-Phytosterols Nanoparticles on Individuals with Metabolic Syndrome: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial |
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