Biotin supplement interference with immunoassays for parathyroid hormone and 25-hydroxyvitamin D in a patient with metabolic bone disease on maintenance hemodialysis
Biotin (vitamin B7) is a dietary supplement that can lead to falsely abnormal endocrine function tests. The impact of biotin on both 25-hydroxyvitamin D [25(OH)D] and intact parathyroid hormone (iPTH) have not been previously described in end-stage renal disease (ESRD). A woman with ESRD on hemodial...
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| Veröffentlicht in: | Clinical Kidney Journal 2020-08, Vol.13 (4), p.710-712 |
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| creator | Plasse, Richard A Olson, Stephen W Yuan, Christina M Nee, Robert |
| description | Biotin (vitamin B7) is a dietary supplement that can lead to falsely abnormal endocrine function tests. The impact of biotin on both 25-hydroxyvitamin D [25(OH)D] and intact parathyroid hormone (iPTH) have not been previously described in end-stage renal disease (ESRD). A woman with ESRD on hemodialysis taking biotin 10 mg daily had a 25(OH)D spike from 25 to >100 ng/mL and an iPTH decrease from 966 to 63 pg/mL. After discontinuation of biotin, her 25(OH)D and iPTH returned to baseline. Biotin can cause erroneous 25(OH)D and iPTH results in ESRD that could adversely affect patient care. |
| doi_str_mv | 10.1093/ckj/sfz134 |
| format | Article |
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The impact of biotin on both 25-hydroxyvitamin D [25(OH)D] and intact parathyroid hormone (iPTH) have not been previously described in end-stage renal disease (ESRD). A woman with ESRD on hemodialysis taking biotin 10 mg daily had a 25(OH)D spike from 25 to >100 ng/mL and an iPTH decrease from 966 to 63 pg/mL. After discontinuation of biotin, her 25(OH)D and iPTH returned to baseline. 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Biotin can cause erroneous 25(OH)D and iPTH results in ESRD that could adversely affect patient care.</description><subject>Alfacalcidol</subject><subject>Biotin</subject><subject>Bone diseases</subject><subject>Calcifediol</subject><subject>Causes of</subject><subject>Diagnostic errors</subject><subject>Diet therapy</subject><subject>Exceptional Case</subject><subject>Function tests (Medicine)</subject><subject>Health aspects</subject><subject>Testing</subject><subject>Vitamin D</subject><issn>2048-8513</issn><issn>2048-8505</issn><issn>2048-8513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptkl1r1zAUxosobszd-AkC3ojQrXlp2t4Ic77CwBu9DqfJ6ZrZJDVpN-v38Xua-h_iwOQib8_zOw_hFMVzWp3RquPn-tvNeRp-Ui4eFcesEm3Z1pQ__md_VJymdFPlkU-VqJ8WR5x1VU0belz8emPDYj1J6zxP6NAvxPoF44ARvUZyZ5eRWOdWHyAl2BIZQiQzRFjGLQZryBiiCx4JeENYXY6bieHHdmsXcJn7NuMIZMNid_YfnMMF-jBZTfrdaGxCSEiCJw724h72yiO6YCxMW7LpWfFkgCnh6f16Unx9_-7L5cfy6vOHT5cXV6UWNVtKBCag6_qOcRC9Yb3UQpu-pgx7qmXTtIZx5BW0bdsZ0UqpW6FlC6ah2cv5SfH6wJ3X3qHROXKESc3ROoibCmDVwxdvR3UdblUjZFN3XQa8vAfE8H3FtChnk8ZpAo9hTYoJQSWlshFZ-uIgvYYJlfVDyES9y9WFFHXVMC73RGf_UeVp0Fmdv2-w-f6B4dXBoGNIKeLwNz2t1N4xKneMOnQM_w3nHrew</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Plasse, Richard A</creator><creator>Olson, Stephen W</creator><creator>Yuan, Christina M</creator><creator>Nee, Robert</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4805-6359</orcidid></search><sort><creationdate>20200801</creationdate><title>Biotin supplement interference with immunoassays for parathyroid hormone and 25-hydroxyvitamin D in a patient with metabolic bone disease on maintenance hemodialysis</title><author>Plasse, Richard A ; Olson, Stephen W ; Yuan, Christina M ; Nee, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-ea24a99b923a4bd2b6c4cdb512eb1c6778d23e30a8889d4866c84c68ad71ea233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alfacalcidol</topic><topic>Biotin</topic><topic>Bone diseases</topic><topic>Calcifediol</topic><topic>Causes of</topic><topic>Diagnostic errors</topic><topic>Diet therapy</topic><topic>Exceptional Case</topic><topic>Function tests (Medicine)</topic><topic>Health aspects</topic><topic>Testing</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plasse, Richard A</creatorcontrib><creatorcontrib>Olson, Stephen W</creatorcontrib><creatorcontrib>Yuan, Christina M</creatorcontrib><creatorcontrib>Nee, Robert</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical Kidney Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plasse, Richard A</au><au>Olson, Stephen W</au><au>Yuan, Christina M</au><au>Nee, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotin supplement interference with immunoassays for parathyroid hormone and 25-hydroxyvitamin D in a patient with metabolic bone disease on maintenance hemodialysis</atitle><jtitle>Clinical Kidney Journal</jtitle><date>2020-08-01</date><risdate>2020</risdate><volume>13</volume><issue>4</issue><spage>710</spage><epage>712</epage><pages>710-712</pages><issn>2048-8513</issn><issn>2048-8505</issn><eissn>2048-8513</eissn><abstract>Biotin (vitamin B7) is a dietary supplement that can lead to falsely abnormal endocrine function tests. The impact of biotin on both 25-hydroxyvitamin D [25(OH)D] and intact parathyroid hormone (iPTH) have not been previously described in end-stage renal disease (ESRD). A woman with ESRD on hemodialysis taking biotin 10 mg daily had a 25(OH)D spike from 25 to >100 ng/mL and an iPTH decrease from 966 to 63 pg/mL. After discontinuation of biotin, her 25(OH)D and iPTH returned to baseline. Biotin can cause erroneous 25(OH)D and iPTH results in ESRD that could adversely affect patient care.</abstract><pub>Oxford University Press</pub><pmid>32905171</pmid><doi>10.1093/ckj/sfz134</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-4805-6359</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical Kidney Journal, 2020-08, Vol.13 (4), p.710-712 |
| issn | 2048-8513 2048-8505 2048-8513 |
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| source | DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alfacalcidol Biotin Bone diseases Calcifediol Causes of Diagnostic errors Diet therapy Exceptional Case Function tests (Medicine) Health aspects Testing Vitamin D |
| title | Biotin supplement interference with immunoassays for parathyroid hormone and 25-hydroxyvitamin D in a patient with metabolic bone disease on maintenance hemodialysis |
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